Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

home browse blast search advanced search help

Quick search:

Description

Entry page for Effector - 'Adenylate cyclase 1-Homo sapiens'

Family	Cyclases
Sub-Family	Adenylate cyclases
Type	Adenylate cyclase 1

Cross References:

References

UniProt	Q08828 \| A4D2L8 \| Q75MI1
EMBL	AC069008 \| AC091439 \| CH236960 \| L05500
InterPro	IPR001054 \| IPR018297
PRODOM
GENEID	107
MIM	103072
PRINTS
PFAM	PF00211

Details:

Details

Name	Adenylate cyclase 1-Homo sapiens
Description	RecName: Full=Adenylate cyclase type 1; EC=4.6.1.1;AltName: Full=Adenylate cyclase type I;AltName: Full=ATP pyrophosphate-lyase 1;AltName: Full=Adenylyl cyclase 1;AltName: Full=Ca(2+)/calmodulin-activated adenylyl cyclase
Species	Homo sapiens
Common Name	Human
NCBI Taxonomy	9606
Gene	ADCY
Function	This is a calmodulin-sensitive adenylyl cyclase
Fragment	0
Sequence	MAGAPRGGGGGGGGAGEPGGAERAAGTSRRRGLRACDEEFACPELEALFRGYTLRLEQAA TLKALAVLSLLAGALALAELLGAPGPAPGLAKGSHPVHCVLFLALLVVTNVRSLQVPQLQ QVGQLALLFSLTFALLCCPFALGGPARGSAGAAGGPATAEQGVWQLLLVTFVSYALLPVR SLLAIGFGLVVAASHLLVTATLVPAKRPRLWRTLGANALLFVGVNMYGVFVRILTERSQR KAFLQARSCIEDRLRLEDENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHD NVSILFADIVGFTGLASQCTAQELVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGL TQPKTDHAHCCVEMGLDMIDTITSVAEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWS NDVTLANVMEAAGLPGKVHITKTTLACLNGDYEVEPGYGHERNSFLKTHNIETFFIVPSH RRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALR TASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQK YHQLQDEYFTSAVVLTLILAALFGLVYLLIFPQSVVVLLLLVFCICFLVACVLYLHITRV QCFPGCLTIQIRTVLCIFIVVLIYSVAQGCVVGCLPWAWSSKPNSSLVVLSSGGQRTALP TLPCESTHHALLCCLVGTLPLAIFFRVSSLPKMILLSGLTTSYILVLELSGYTRTGGGAV SGRSYEPIVAILLFSCALALHARQVDIRLRLDYLWAAQAEEEREDMEKVKLDNRRILFNL LPAHVAQHFLMSNPRNMDLYYQSYSQVGVMFASIPNFNDFYIELDGNNMGVECLRLLNEI IADFDELMEKDFYKDIEKIKTIGSTYMAAVGLAPTSGTKAKKSISSHLSTLADFAIEMFD VLDEINYQSYNDFVLRVGINVGPVVAGVIGARRPQYDIWGNTVNVASRMDSTGVQGRIQV TEEVHRLLRRCPYHFVCRGKVSVKGKGEMLTYFLEGRTDGNGSQIRSLGLDRKMCPFGRA GLQGRRPPVCPMPGVSVRAGLPPHSPGQYLPSAAAGKEA

Interacting with G-proteins:

G-proteins

No	Name	Regulation	PubMed
1	Ggamma-8_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
2	Ggamma-4_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
3	Ggamma-5_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
4	Gbeta-4_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
5	Galpha-i2_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933
6	Ggamma-11_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
7	Gbeta-5_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
8	Gbeta-1_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
9	Ggamma-2_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
10	Galpha-s_Homo sapiens_2	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
11	Gbeta-like_Homo sapiens_1	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
12	Ggamma-t1_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
13	Galpha-i1_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933
14	Ggamma-10_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
15	Ggamma-12_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
16	Ggamma-13_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
17	Ggamma-t2_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
18	Galpha-s_Homo sapiens_1	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
19	Gbeta-3_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
20	Galpha-i3_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933
21	Ggamma-7_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
22	Gbeta-like_Homo sapiens_2	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
23	Galpha-o_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933
24	Gbeta-2_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
25	Ggamma-3_Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level