Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Description

Entry page for Effector - 'Phospholipase C beta 3-Homo sapiens'

Family	Phospholipases C
Sub-Family	Phospholipases C beta
Type	Phospholipase C beta 3

Cross References:

References

UniProt	Q01970
EMBL	U26425 \| Z37544 \| Z37545 \| Z37546 \| Z37547 \| Z37548 \| Z37549 \| Z37550 \| Z37551 \| Z37552 \| Z37553 \| Z37554 \| Z37555 \| Z37556 \| Z37557 \| Z37558 \| Z37559 \| Z37560 \| Z37561 \| Z37562 \| Z37564 \| Z37565 \| Z37566 \| Z37567 \| Z37568 \| Z37569 \| Z37570 \| Z37571 \| Z37572 \| Z37573 \| Z37574 \| Z16411
InterPro	IPR000008 \| IPR018029 \| IPR011992 \| IPR015359 \| IPR001192 \| IPR000909 \| IPR001711 \| IPR016280 \| IPR014815 \| IPR017946
PRODOM	PD001202
GENEID	5331
MIM	600230
PRINTS	PR00390
PFAM	PF00168 \| PF09279 \| PF00388 \| PF00387 \| PF08703

Details:

Details

Name	Phospholipase C beta 3-Homo sapiens
Description	"RecName: Full=1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3; EC=3.1.4.11;AltName: Full=Phosphoinositide phospholipase C;AltName: Full=Phospholipase C-beta-3; Short=PLC-beta-3;"
Species	Homo sapiens
Common Name	Human
NCBI Taxonomy	9606
Gene	PLCB
Function	The production of the second messenger moleculess diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) iss mediated by activated phosphatidylinositol-specific phospholipases C enzymes
Fragment	0
Sequence	MAGAQPGVHALQLEPPTVVETLRRGSKFIKWDEETSSRNLVTLRVDPNGFFLYWTGPNME VDTLDISSIRDTRTGRYARLPKDPKIREVLGFGGPDARLEEKLMTVVSGPDPVNTVFLNF MAVQDDTAKVWSEELFKLAMNILAQNASRNTFLRKAYTKLKLQVNQDGRIPVKNILKMFS ADKKRVETALESCGLKFNRSESIRPDEFSLEIFERFLNKLCLRPDIDKILLEIGAKGKPY LTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKYEPNQQFLERDQMSMEGFSRYL GGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAGQLAGTSSVEMYRQALLWGCRC VELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAETAFKTSPYPVILSFENHVDSAK QQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDLMGRILVKNKKRHRPSAGGPDS AGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGLSNGEEVGLEKPSLEPQKSLGD EGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGTASSEVNATEEMSTLVNYIEPV KFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTRVDSSNYM PQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFDPFTEVIV DGIVANALRVKVISGQFLSDRKVGIYVEVDMFGLPVDTRRKYRTRTSQGNSFNPVWDEEP FDFPKVVLPTLASLRIAAFEEGGKFVGHRILPVSAIRSGYHYVCLRNEANQPLCLPALLI YTEASDYIPDDHQDYAEALINPIKHVSLMDQRARQLAALIGESEAQAGQETCQDTQSQQL GSQPSSNPTPSPLDASPRRPPGPTTSPASTSLSSPGQRDDLIASILSEVAPTPLDELRGH KALVKLRSRQERDLRELRKKHQRKAVTLTRRLLDGLAQAQAEGRCRLRPGALGGAADVED TKEGEDEAKRYQEFQNRQVQSLLELREAQVDAEAQRRLEHLRQALQRLREVVLDANTTQF KRLKEMNEREKKELQKILDRKRHNSISEAKMRDKHKKEAELTEINRRHITESVNSIRRLE EAQKQRHDRLVAGQQQVLQQLAEEEPKLLAQLAQECQEQRARLPQEIRRSLLGEMPEGLG DGPLVACASNGHAPGSSGHLSGADSESQEENTQL

Interacting with G-proteins:

G-proteins

No	Name	Regulation	PubMed
1	Ggamma-8_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
2	Galpha-q_Homo sapiens	Stimulation of PLC-beta catalytic activity	15251227 \| 16182515 \| 11015615
3	Ggamma-4_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
4	Ggamma-5_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
5	Gbeta-4_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
6	Ggamma-11_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
7	Gbeta-5_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
8	Galpha-11_Homo sapiens	Stimulation of PLC-beta catalytic activity	15251227 \| 16182515 \| 11015615
9	Gbeta-1_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
10	Ggamma-2_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
11	Gbeta-like_Homo sapiens_1	Stimulation	15251227 \| 11015615 \| 8383116
12	Ggamma-t1_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
13	Ggamma-10_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
14	Ggamma-12_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
15	Ggamma-13_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
16	Ggamma-t2_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
17	Gbeta-3_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
18	Galpha-14_Homo sapiens	Stimulation of PLC-beta catalytic activity	15251227 \| 16182515 \| 11015615
19	Ggamma-7_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
20	Gbeta-like_Homo sapiens_2	Stimulation	15251227 \| 11015615 \| 8383116
21	Gbeta-2_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
22	Ggamma-3_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
23	Galpha-15_Homo sapiens	Stimulation of PLC-beta catalytic activity	15251227 \| 16182515 \| 11015615

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level