Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Description

Entry page for Effector - 'Tubulin-Homo sapiens-27'

Family	Tubulins
Sub-Family	Tubulins
Type	Tubulin

Cross References:

References

UniProt	Q96RT7 \| Q5JZ80 \| Q6PJ40 \| Q86YE9 \| Q9BY91 \| Q9UGX3 \| Q9UGX4
EMBL	AF272887 \| AL022328 \| AB051456 \| BC023573 \| BC042165
InterPro	IPR007259
PRODOM
GENEID	85378
MIM	610053
PRINTS
PFAM	PF04130

Details:

Details

Name	Tubulin-Homo sapiens-27
Description	RecName: Full=Gamma-tubulin complex component 6; Short=GCP-6
Species	Homo sapiens
Common Name	Human
NCBI Taxonomy	9606
Gene	TUBGCP6 \| GCP6,KIAA166
Function	Gamma-tubulin complex is necessary for microtubules nucleation at the centrosome
Fragment	0
Sequence	MASITQLFDDLCEALLPAAKTHLGQRSVNRKRAKRSLKKVAYNALFTNLFQDETQQLQPD MSKLPARNKILMLSFDLRVGGLGPKADRLEELVEELEAAPCCPLLEVGSVLDLLVQLAGS GPPQVLPRKRDYFLNNKHVGRNVPYSGYDCDDLSVFEMDVQSLISREECLCHSMIQETLQ VMEAAPGTGLPTVGLFSFGDPCGDRFERDTRVSLFGALVHSRTYDMDVRLGLPPVPDNAD LSGLAIKVPPSVDQWEDEGFQSASNLTPDSQSEPSVTPDVDLWEAALTYEASKRRCWERV GCPPGHREEPYLTEAGRDAFDKFCRLHQGELQLLAGGVLQAPQPVLVKECELVKDVLNVL IGVVSATFSLCQPAQAFVVKRGVHVSGASPESISSLLSEVAEYGTCYTRLSHFSLQPVLD SLYSKGLVFQAFTSGLRRYLQYYRACVLSTPPTLSLLTIGFLFKKLGRQLRYLAELCGVG AVLPGTCGGGPRAAFPTGVKLLSYLYQEALHNCSNEHYPVLLSLLKTSCEPYTRFIHDWV YSGVFRDAYGEFMIQVNHEYLSFRDKLYWTHGYVLISKEVEDCVPVFLKHIAHDIYVCGK TINLLKLCCPRHYLCWSDVPVPRISVIFSLEELKEIEKDCAVYVGRMERVARHSSVSKEE KELRMEIAKQELIAHAREAASRVLSALSDRQMSERMALDARKREQFQRLKEQFVKDQERR QAARQEELDDDFSYARELRDRERRLKSLEEELERKARQALVDHYSKLSAEAARREQKALW RIQRHRLESARLRFLLEDEKHIQEMLKAVSEAHQPQEPPDVLLSVHPQVTSPGPEHPEGG QGCDSGSAEQHSPAWDGWNRPGLLTPQPLKPLAVGAGGRGLQQAEGARPFSDSLSIGDFL PVGPGAEPSVQTGMVPLLEVALQTINLDLPPSAPGEAPAAASTQPSRPQEYDFSTVLRPA VATSPAPGPLQAAECSLGSSGLQLWEDSCGKMDACGSASRETLLPSHPPRRAALEEGSSQ PTERLFGQVSGGGLPTGDYASEIAPTRPRWNTHGHVSDASIRVGENVSDVAPTQPRWNTH GHVSNASISLGESVSDVAPTRPRWNIHGHVSNASIRVGENVSDVAPTRPRWNTHGHVSNA SIRVGENVSDVAPTRPRWNTHGHVSDASISLGESVSDMAPARPRWNTHGHVSDASISLGE SVSDMAPTRPRWNTHGHVSDTSIRVGENVSDVAPIRSRCNTHGHVSDASISLGEPVSDVV STRPRWNTHVPIPPPHMVLGALSPEAEPNTPRPQQSPPGHTSQSALSLGAQSTVLDCGPR LPVEVGPSLSSPSSGCGEGSISVGENVSDVAPTQPWWPNTPGDSVSEELGPGRSGDTEDL SPNWPLNSQEDTAAQSSPGRGEEAEASAAEAQGGEQAYLAGLAGQYHLERYPDSYESMSE PPIAHLLRPVLPRAFAFPVDPQVQSAADETAVQLSELLTLPVLMKRSITAPLAAHISLVN KAAVDYFFVELHLEAHYEALRHFLLMEDGEFAQSLSDLLFEKLGAGQTPGELLNPLVLNS VLSKALQCSLHGDTPHASNLSLALKYLPEVFAPNAPDVLSCLELRYKVDWPLNIVITEGC VSKYSGVFSFLLQLKLMMWALKDVCFHLKRTALLSHMAGSVQFRQLQLFKHEMQHFVKVI QGYIANQILHVTWCEFRARLATVGDLEEIQRAHAEYLHKAVFRGLLTEKAAPVMNVIHSI FSLVLKFRSQLISQAWGPPGGPRGAEHPNFALMQQSYNTFKYYSHFLFKVVTKLVNRGYQ PHLEDFLLRINFNNYYQDA

Interacting with G-proteins:

G-proteins

No	Name	Regulation	PubMed
1	Ggamma-8_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
2	Galpha-q_Homo sapiens	Potentiates receptor-induced PLC-beta activation	16182515
3	Ggamma-4_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
4	Ggamma-5_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
5	Gbeta-4_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
6	Galpha-i2_Homo sapiens	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
7	Ggamma-11_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
8	Gbeta-5_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
9	Gbeta-1_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
10	Ggamma-2_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
11	Galpha-s_Homo sapiens_2	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
12	Gbeta-like_Homo sapiens_1	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
13	Ggamma-t1_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
14	Ggamma-12_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
15	Galpha-i1_Homo sapiens	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
16	Ggamma-10_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
17	Ggamma-13_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
18	Ggamma-t2_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
19	Galpha-s_Homo sapiens_1	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
20	Gbeta-3_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
21	Galpha-i3_Homo sapiens	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
22	Ggamma-7_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
23	Gbeta-like_Homo sapiens_2	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
24	Gbeta-2_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
25	Galpha-o_Homo sapiens	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
26	Ggamma-3_Homo sapiens	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level