Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Description

Entry page for G-protein - 'Galpha-s_Homo sapiens_1'

Class	Galpha
Family	Gs
Sub-Family	Galpha-s
Type	Galpha-s

Cross References:

References

UniProt	Q5JWF2 \| A2A2S3 \| O75684 \| O75685 \| Q5JW67 \| Q5JWF1 \| Q9NY42
EMBL	AL109840 \| AL121917 \| AL132655 \| AL109840 \| AL121917 \| AL132655 \| AL121917 \| AL109840 \| AL132655 \| AL121917 \| AL109840 \| AL132655 \| AL132655 \| AL109840 \| AL121917 \| AL132655 \| AL109840 \| AL121917 \| AL132655 \| AJ251760 \| AJ224867 \| AJ224868 \| AY898804
InterPro	IPR001019 \| IPR000367
PRODOM	PD000281
GENEID	2778
MIM	139320 \| 219080 \| 603233
PRINTS	PR00318 \| PR00443
PFAM	PF00503

Details:

Details

Name	Galpha-s_Homo sapiens_1
Description	RecName: Full=Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas;AltName: Full=Adenylate cyclase-stimulating G alpha protein;AltName: Full=Extra large alphas protein; Short=XLalphas
Species	Homo sapiens
Common Name	Human
NCBI Taxonomy	9606
Gene	GNAS \| GNAS
Function	Guanine nucleotide-binding proteins (G proteins) ares involved as modulators or transducers in various transmembranes signaling systems
Fragment	0
Sequence	MGVRNCLYGNNMSGQRDIPPEIGEQPEQPPLEAPGAAAPGAGPSPAEEMETEPPHNEPIP VENDGEACGPPEVSRPNFQVLNPAFREAGAHGSYSPPPEEAMPFEAEQPSLGGFWPTLEQ PGFPSGVHAGLEAFGPALMEPGAFSGARPGLGGYSPPPEEAMPFEFDQPAQRGCSQLLLQ VPDLAPGGPGAAGVPGAPPEEPQALRPAKAGSRGGYSPPPEETMPFELDGEGFGDDSPPP GLSRVIAQVDGSSQFAAVAASSAVRLTPAANAPPLWVPGAIGSPSQEAVRPPSNFTGSSP WMEISGPPFEIGSAPAGVDDTPVNMDSPPIALDGPPIKVSGAPDKRERAERPPVEEEAAE MEGAADAAEGGKVPSPGYGSPAAGAASADTAARAAPAAPADPDSGATPEDPDSGTAPADP DSGAFAADPDSGAAPAAPADPDSGAAPDAPADPDSGAAPDAPADPDAGAAPEAPAAPAAA ETRAAHVAPAAPDAGAPTAPAASATRAAQVRRAASAAPASGARRKIHLRPPSPEIQAADP PTPRPTRASAWRGKSESSRGRRVYYDEGVASSDDDSSGDESDDGTSGCLRWFQHRRNRRR RKPQRNLLRNFLVQAFGGCFGRSESPQPKASRSLKVKKVPLAEKRRQMRKEALEKRAQKR AEKKRSKLIDKQLQDEKMGYMCTHRLLLLGAGESGKSTIVKQMRILHVNGFNGEGGEEDP QAARSNSDGEKATKVQDIKNNLKEAIETIVAAMSNLVPPVELANPENQFRVDYILSVMNV PDFDFPPEFYEHAKALWEDEGVRACYERSNEYQLIDCAQYFLDKIDVIKQADYVPSDQDL LRCRVLTSGIFETKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVI REDNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIEDYFPEFAR YTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYCYPHFTCAVDTENIRRVFN DCRDIIQRMHLRQYELL

Effectors:

Effectors

No	Name	Regulation	PubMed
1	Tubulin-Homo sapiens-3	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
2	Tubulin-Homo sapiens-1	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
3	Tubulin-Homo sapiens-10	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
4	Adenylate cyclase 7-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
5	Tubulin-Homo sapiens-19	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
6	Adenylate cyclase 2-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
7	Adenylate cyclase 1-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
8	Tubulin-Homo sapiens-26	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
9	Tubulin-Homo sapiens-11	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
10	Tubulin-Homo sapiens-20	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
11	Tubulin-Homo sapiens-22	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
12	Tubulin-Homo sapiens-13	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
13	Tubulin-Homo sapiens-8	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
14	Tubulin-Homo sapiens-21	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
15	Tubulin-Homo sapiens-14	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
16	Tubulin-Homo sapiens-5	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
17	Tubulin-Homo sapiens-27	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
18	Tubulin-Homo sapiens-4	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
19	Tubulin-Homo sapiens-17	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
20	Tubulin-Homo sapiens-18	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
21	Tubulin-Homo sapiens-25	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
22	Tubulin-Homo sapiens-6	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
23	Tubulin-Homo sapiens-16	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
24	Tubulin-Homo sapiens-9	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
25	Src tyrosine kinase-Homo sapiens-1	Stimulation	11007482 \| 15251227 \| 12209124
26	Adenylate cyclase 6-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
27	Tubulin-Homo sapiens-23	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
28	Adenylate cyclase 3-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
29	Tubulin-Homo sapiens-7	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
30	Adenylate cyclase 9-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
31	RGS PX1-Homo sapiens	Stimulation	15251227
32	Tubulin-Homo sapiens-2	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
33	Adenylate cyclase 8-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
34	Adenylate cyclase 4-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
35	Src tyrosine kinase-Homo sapiens-2	Stimulation	11007482 \| 15251227 \| 12209124
36	Tubulin-Homo sapiens-12	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
37	Tubulin-Homo sapiens-24	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
38	Tubulin-Homo sapiens-15	Stimulation of GTPase activity	10224115 \| 15251227 \| 16380086
39	Adenylate cyclase 5-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933

Interacton with GPCRs:

Coupling with GPCRs

Name

Coupling

PubMed