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Description Entry page for G-protein - 'Gbeta-1_Homo sapiens'
ClassGbeta
FamilyGbeta
Sub-FamilyGbeta
TypeGbeta-1
Cross References:
References
UniProtP62873 | B1AJZ7 | P04697 | P04901
EMBLX04526 | AF501882 | BT007305 | CR456784 | AL031282 | AL109917 | AL109917 | AL031282 | CH471183 | BC004186 | BC005888 | BC008991 | M36430
InterProIPR020472 | IPR001632 | IPR016346 | IPR015943 | IPR001680 | IPR019782 | IPR019775 | IPR017986 | IPR019781
PRODOMPD000018
GENEID2782
MIM139380
PRINTSPR00319 | PR00320
PFAMPF00400
Details:
Details
NameGbeta-1_Homo sapiens
DescriptionRecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1;AltName: Full=Transducin beta chain 1
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneGNB
FunctionGuanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment0
Sequence
MSELDQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYA
MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNI
CSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTF
TGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNA
FATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDAL
KADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Effectors:
Effectors
NoNameRegulationPubMed
1SHC transforming protein 2-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
2Tubulin-Homo sapiens-3Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
3Tubulin-Homo sapiens-10Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
4Adenylate cyclase 7-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
5GRK3-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
6Tubulin-Homo sapiens-19Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
7Voltage dependent R type calcium channel-Homo sapiensInhibition15251227 | 11031246
8Calmodulin-Homo sapiensInhibition of calmodulin kinase15251227
9Tubulin-Homo sapiens-11Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
10ATP-sensitive inward rectifier potassium channel 8-Homo sapiensStimulation15251227 | 10990455
11Phospholipase C beta 3-Homo sapiensStimulation15251227 | 11015615 | 8383116
12Tubulin-Homo sapiens-22Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
13Tubulin-Homo sapiens-13Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
14Tubulin-Homo sapiens-8Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
15Ras specific nucleotide exchange factor CDC25-Homo sapiensStimulation (indirect activation of ras)15251227 | 8717044
16Rho-Homo sapiens-3Recruitment to plasma membrane15251227
17Dynamin 1-Homo sapiensIncreased GTPase activity15251227 | 14671004
18Tubulin-Homo sapiens-5Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
19Tubulin-Homo sapiens-27Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
20ATP-sensitive inward rectifier potassium channel 10-Homo sapiensStimulation15251227 | 10990455
21ATP-sensitive inward rectifier potassium channel 11-Homo sapiensStimulation15251227 | 10990455
22Tubulin-Homo sapiens-4Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
23Tubulin-Homo sapiens-17Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
24PI3K gamma-Homo sapiensActivation12502714
25Tubulin-Homo sapiens-25Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
26Tubulin-Homo sapiens-6Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
27Tubulin-Homo sapiens-16Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
28Kinase suppressor of Ras(KSR)-Homo sapiensSequestration of Gbeta/gamma15251227
29Rac-Homo sapiens-1"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
30SHC transforming protein 3-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
31Voltage dependent N type calcium channel-Homo sapiensInhibition15251227 | 11031246
32ATP-sensitive inward rectifier potassium channel 12-Homo sapiensStimulation15251227 | 10990455
33ATP-sensitive inward rectifier potassium channel 1-Homo sapiensStimulation15251227 | 10990455
34Rac-Homo sapiens-3"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
35Tubulin-Homo sapiens-2Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
36Rho-Homo sapiens-2Recruitment to plasma membrane15251227
37Tubulin-Homo sapiens-12Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
38Cdc42-Homo sapiens"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
39Tubulin-Homo sapiens-15Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
40Tubulin-Homo sapiens-24Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
41SHC transforming protein 1-Homo sapiensStimulation(indirect activation of MAPK)15251227 | 14671004 | 7568118
42Tubulin-Homo sapiens-1Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
43Adenylate cyclase 2-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
44Brutons tyrosine kinase-Homo sapiensStimulation15251227 | 11698416
45Adenylate cyclase 1-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933 | 10449730
46Tubulin-Homo sapiens-26Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
47Tubulin-Homo sapiens-20Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
48GRK2-Homo sapiensRecruitment to plasma membrane15251227 | 14654303
49Tubulin-Homo sapiens-14Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
50Tubulin-Homo sapiens-21Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
51ATP-sensitive inward rectifier potassium channel 15-Homo sapiensStimulation15251227 | 10990455
52Rho-Homo sapiens-1Recruitment to plasma membrane15251227
53Tsk tyrosine kinase-Homo sapiensStimulation15251227 | 14671004
54Protein kinase D-Homo sapiensStimulation15251227
55Raf1 protein kinase-Homo sapiensSequestration of Gâã15251227
56Tubulin-Homo sapiens-18Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
57Phospholipase C beta 1-Homo sapiensStimulation15251227 | 11015615 | 8383116
58PI3K alpha-Homo sapiensPropable Inhibition16182515
59ATP-sensitive inward rectifier potassium channel 14-Homo sapiensStimulation15251227 | 10990455
60Tubulin-Homo sapiens-9Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
61Adenylate cyclase 6-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
62Tubulin-Homo sapiens-23Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
63Tubulin-Homo sapiens-7Increased GTPase activity15251227 | 14671004 | 12807915 | 17705289 | 16380086
64Rac-Homo sapiens-2"Stimulation,Recruitment to plasma membrane"11099498 | 15251227
65PI3K beta-Homo sapiensActivation9305878 | 12502714
66Adenylate cyclase 4-Homo sapiensStimulation15251227 | 15922020 | 14993377 | 11376933
67Voltage dependent P/Q type calcium channel-Homo sapiensInhibition15251227 | 11031246
68Phospholipase C beta 2-Homo sapiensStimulation15251227 | 11015615 | 8383116
69Adenylate cyclase 5-Homo sapiensInhibition15251227 | 15922020 | 14993377 | 11376933
Interacton with GPCRs:
Coupling with GPCRs
NoNameCouplingPubMed