Human-gpDB    A database of human GPCRs, G-proteins, Effectors and their interactions

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	Summary sheet information for Effector 'Brutons tyrosine kinase-Homo sapiens'
Name	Brutons tyrosine kinase-Homo sapiens
Description	RecName: Full=Tyrosine-protein kinase BTK; EC=2.7.10.2;AltName: Full=Bruton tyrosine kinase;AltName: Full=Agammaglobulinaemia tyrosine kinase; Short=ATK;AltName: Full=B-cell progenitor kinase; Short=BPK
Class
Family	Tyr protein kinases
Sub_family	Tyr protein kinases
type	Brutons tyrosine kinase
Protein features link	Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction	Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes	Gene Location: Chromosome : X Gene Start : 100491091 Gene End : 100527838 Ensembl Contig View Ensembl Genes: ENSG00000010671 EMBL: EMBL ID    Description AF153364    Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153755    Homo sapiens Bruton's tyrosine kinase mRNA, partial cds. AF153756    Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153757    Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153758    Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153759    Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153760    Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153761    Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153762    Homo sapiens Bruton's tyrosine kinase mRNA, complete cds. AF153763    Homo sapiens Bruton's tyrosine kinase mRNA, partial cds. AF153764    Homo sapiens Bruton's tyrosine kinase mRNA, partial cds. AJ888376    Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform 65 (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia AJ888378    Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform 52 (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia AJ888380    Homo sapiens partial mRNA for tyrosine-protein kinase BTK isoform (lacking exon 15 to 18) (BTK gene), tissue type BCR-ABL1+ pre-B lymphoblastic leukemia AK314382    Homo sapiens cDNA, FLJ95155, highly similar to Homo sapiens Bruton agammaglobulinemia tyrosine kinase (BTK), mRNA. AL035422    Human DNA sequence from clone RP1-164F3 on chromosome Xq21.33-23 Contains a ribosomal protein L21 (RPL21) pseudogene, the TIMM8A gene for translocase of inner mitochondrial membrane 8 homolog A (yeast), the BTK gene for Bruton agammaglobulinemia tyrosine kinase, the RPL36A gene for ribosomal protein L36a, the GLA gene for alpha galactosidase, the HNRPH2 gene for heterogeneous nuclear ribonucleoprotein H2 (H'), the gene for a novel protein, a peptidylprolyl isomerase A (cyclophilin A) (PPIA) pseudogene and two CpG islands. AM051276    Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 2 (BTK kinase deficient isoform 2 gene), cell type MLL-AF4+ leukemia cells AM051277    Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 3 (BTK kinase deficient isoform 3 gene), cell type MLL-AF4+ leukemia cells AM051278    Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 4 (BTK kinase deficient isoform 4 gene), cell type BCR-ABL1+ leukemia cells AM051279    Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 5 (BTK kinase deficient isoform 5 gene), cell type BCR-ABL1+ leukemia cells AM051280    Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 6 (BTK kinase deficient isoform 6 gene), cell type BCR-ABL1+ leukemia cells AM051283    Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 9 (BTK kinase deficient isoform 9 gene), cell type TEL-AML1+ leukemia cells AM051284    Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 10 (BTK kinase deficient isoform 10 gene), cell type TEL-AML1+ leukemia cells AM051285    Homo sapiens partial mRNA for dominant-negative kinase-deficient Brutons tyrosine kinase isoform 11 (BTK kinase deficient isoform 11 gene), cell type E2A-PBX1+ leukemia cells BC109079    Homo sapiens Bruton agammaglobulinemia tyrosine kinase, mRNA (cDNA clone MGC:126261 IMAGE:40034287), complete cds. BC109080    Homo sapiens Bruton agammaglobulinemia tyrosine kinase, mRNA (cDNA clone MGC:126262 IMAGE:40034289), complete cds. CH471115    Homo sapiens 211000035842956 genomic scaffold, whole genome shotgun sequence. L31557    Human Bruton agammaglobulinemia (BTK) gene, exon 2. L31558    Human Bruton agammaglobulinemia (BTK) gene, exon 3. L31559    Human Bruton agammaglobulinemia (BTK) gene, exon 4. L31561    Human Bruton agammaglobulinemia (BTK) gene, exons 6-7. L31563    Human Bruton agammaglobulinemia (BTK) gene, exon 8. L31564    Human Bruton agammaglobulinemia (BTK) gene, exon 9. L31565    Human Bruton agammaglobulinemia (BTK) gene, exons 10-12. L31566    Human Bruton agammaglobulinemia (BTK) gene, exon 13. L31567    Human Bruton agammaglobulinemia (BTK) gene, exon 14. L31568    Human Bruton agammaglobulinemia (BTK) gene, exon 15. L31569    Human Bruton agammaglobulinemia (BTK) gene, exon 16. L31570    Human Bruton agammaglobulinemia (BTK) gene, exon 17. L31571    Human Bruton agammaglobulinemia (BTK) gene, exon 18. L31572    Human Bruton agammaglobulinemia (BTK) gene exon 19, complete cds. U10084    Human Bruton agammaglobulinemia tyrosine kinase (BTK) gene, exons 2 and 3. U10085    Human Bruton agammaglobulinemia tyrosine kinase (BTK) gene, exon 4. U10086    Human Bruton agammaglobulinemia tyrosine kinase (BTK) gene, exon 5. U10087    Human Bruton agammaglobulinemia tyrosine kinase (BTK) gene, exons 6-19 and complete cds. U13410    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 2. U13412    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 3. U13413    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 4. U13414    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 5. U13415    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 6. U13416    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 7. U13417    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 8. U13422    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 9. U13423    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 10. U13424    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 11. U13425    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 12. U13427    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 13. U13428    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 14. U13429    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 15. U13430    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 16. U13431    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 17. U13432    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 18. U13433    Homo sapiens Bruton's agammaglobulinemia tyrosine kinase (Btk) gene, exon 19 and complete cds. U78027    Homo sapiens Bruton's tyrosine kinase (BTK), alpha-D-galactosidase A (GLA), L44-like ribosomal protein (L44L) and FTP3 (FTP3) genes, complete cds. X58957    H.sapiens atk mRNA for agammaglobulinaemia tyrosine kinase EntrezGene: ID    Description BTK    Bruton agammaglobulinemia tyrosine kinase RefSeq DNA: ID    Description NM_000061    Homo sapiens Bruton agammaglobulinemia tyrosine kinase (BTK), mRNA. UniGene: ID    Description Hs.159494    Atk mRNA for agammaglobulinaemia tyrosine kinase
Proteins	Ensembl Proteins: ENSP00000378608; ENSP00000361950; ENSP00000361946; ENSP00000361951; ENSP00000361971; ENSP00000361960; ENSP00000308176 Entrez Proteins: AAA61479.1; AAB60639.1; AAB64205.1; AAC51347.1; AAF37332.1; AAF37333.1; AAF37334.1; AAF37335.1; AAF37336.1; AAF37337.1; AAF37338.1; AAF37339.1; AAF37340.1; AAF37341.1; AAF61477.1; AAI09080.1; AAI09081.1; BAG37008.1; CAA41728.1; CAB55876.1; CAI42359.1; CAI59837.1; CAI59839.1; CAI59842.1; CAJ19682.1; CAJ19683.1; CAJ19684.1; CAJ19685.1; CAJ19686.1; CAJ19689.1; CAJ19690.1; CAJ19691.1; EAX02857.1 RefSeq Proteins: ID    Description NP_000052    Bruton agammaglobulinemia tyrosine kinase [Homo sapiens]. UniProt: ID    Description B2RAW1    SubName: Full=cDNA, FLJ95155, highly similar to Homo sapiens Bruton agammaglobulinemia tyrosine kinase (BTK), mRNA; Q3MS87    SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 11; Flags: Fragment; Q3MS88    SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 10; Flags: Fragment; Q3MS89    SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 9; Flags: Fragment; Q3MS92    SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 6; Flags: Fragment; Q3MS93    SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 5; Flags: Fragment; Q3MS94    SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 4; Flags: Fragment; Q3MS95    SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 3; Flags: Fragment; Q3MS96    SubName: Full=Dominant-negative kinase-deficient Brutons tyrosine kinase isoform 2; Flags: Fragment; Q572P1    SubName: Full=Tyrosine-protein kinase BTK isoform (Lacking exon 15 to 18); Flags: Fragment; Q572P3    SubName: Full=Tyrosine-protein kinase BTK isoform 52; Flags: Fragment; Q572P5    SubName: Full=Tyrosine-protein kinase BTK isoform 65; Flags: Fragment; Q5JY90    SubName: Full=cDNA FLJ32543 fis, clone SMINT2000538, highly similar to Tyrosine-protein kinase BTK (EC 2.7.10.2); SubName: Full=Bruton agammaglobulinemia tyrosine kinase; SubName: Full=Bruton agammaglobulinemia tyrosine kinase, isoform CRA_b; Q9NPI2    SubName: Full=Bruton's tyrosine kinase; Q9NPI3    SubName: Full=Bruton's tyrosine kinase; Q9P0L3    SubName: Full=Bruton's tyrosine kinase; Flags: Fragment; Q9P0L4    SubName: Full=Bruton's tyrosine kinase; Flags: Fragment; Q9P0L5    SubName: Full=Bruton's tyrosine kinase; Q9P0L6    SubName: Full=Bruton's tyrosine kinase; Q9P0L7    SubName: Full=Bruton's tyrosine kinase; Q9P0L8    SubName: Full=Bruton's tyrosine kinase; Flags: Fragment; Q9P0M0    SubName: Full=Bruton's tyrosine kinase; Q06187    RecName: Full=Tyrosine-protein kinase BTK; EC=2.7.10.2; AltName: Full=Bruton tyrosine kinase; AltName: Full=Agammaglobulinaemia tyrosine kinase; Short=ATK; AltName: Full=B-cell progenitor kinase; Short=BPK;
Domains	SMART: - Hyperlink to SMART; - Hyperlink to ENSEMBL       Brutons tyrosine kinase-Homo sapiens     InterPro: ID    Name IPR000719    Prot_kinase_core IPR011993    PH_type IPR017441    Protein_kinase_ATP_bd_CS IPR001452    SH3_domain IPR001849    Pleckstrin_homology IPR001562    Znf_Btk_motif IPR000980    SH2 IPR008266    Tyr_pkinase_AS IPR001245    Tyr_pkinase Pfam: ID    Description SH2    SH2 domain SH3_1    SH3 domain PH    PH domain BTK    BTK motif Pkinase_Tyr    Protein tyrosine kinase Pkinase_Tyr    Protein tyrosine kinase
Structure	PDB: ID 1AWW 1AWX 1B55 1BTK 1BWN 1K2P 1QLY 2GE9 2Z0P HSSP: ID    Description 1a07    COMPLEX (TRANSFERASE/PEPTIDE) 1a08    COMPLEX (TRANSFERASE/PEPTIDE) 1a09    COMPLEX (TRANSFERASE/PEPTIDE) 1a0n    COMPLEX (PHOSPHOTRANSFERASE/PEPTIDE) 1a1a    COMPLEX (TRANSFERASE/PEPTIDE) 1a1b    COMPLEX (TRANSFERASE/PEPTIDE) 1a1c    COMPLEX (TRANSFERASE/PEPTIDE) 1a1e    COMPLEX (TRANSFERASE/PEPTIDE) 1ab2    TRANSFERASE(PHOSPHOTRANSFERASE) 1ad5    TYROSINE-PROTEIN KINASE 1aot    COMPLEX (PROTO-ONCOGENE/EARLY PROTEIN) 1aou    COMPLEX (PROTO-ONCOGENE/EARLY PROTEIN) 1avz    COMPLEX (MYRISTYLATION/TRANSFERASE) 1awj    TRANSFERASE 1aww    TRANSFERASE 1awx    TRANSFERASE 1aya    HYDROLASE(SH2 DOMAIN) 1ayb    HYDROLASE(SH2 DOMAIN) 1ayc    HYDROLASE(SH2 DOMAIN) 1ayd    HYDROLASE(SH2 DOMAIN) 1azg    COMPLEX (PHOSPHOTRANSFERASE/PEPTIDE) 1b07    SH3 DOMAIN 1b55    TRANSFERASE 1bfi    SH2 DOMAIN 1bfj    SH2 DOMAIN 1bk2    SH3-DOMAIN 1bkl    V-SRC SH2 DOMAIN 1bkm    TRANSFORMING PROTEIN 1btk    TRANSFERASE 1bu1    TRANSFERASE 1bwn    TRANSFERASE 1byg    TRANSFERASE 1cka    COMPLEX (ONCOGENE PROTEIN/PEPTIDE) 1ckb    COMPLEX (ONCOGENE PROTEIN/PEPTIDE) 1csk    PHOSPHOTRANSFERASE 1d1z    GENE REGULATION 1d4t    SIGNALING PROTEIN 1d4w    SIGNALING PROTEIN 1efn    COMPLEX (SH3 DOMAIN/VIRAL ENHANCER) 1f1w    TRANSFERASE 1f2f    TRANSFERASE 1fmk    PHOSPHOTRANSFERASE 1fpu    TRANSFERASE 1fvr    TRANSFERASE 1fyn    TRANSFERASE 1g83    TRANSFERASE 1gag    TRANSFERASE, SIGNALING PROTEIN 1gcq    SIGNALING PROTEIN/SIGNALING PROTEIN 1gfc    ADAPTOR PROTEIN CONTAINING SH2 AND SH3 1gfd    ADAPTOR PROTEIN CONTAINING SH2 AND SH3 1gjo    TRANSFERASE 1gl5    TRANSFERASE 1h92    TRANSFERASE 1h9o    COMPLEX (PHOSPHOTRANSFERASE/RECEPTOR) 1hcs    COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) 1hct    COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) 1hd3    CYTOSKELETON 1i44    TRANSFERASE 1iep    TRANSFERASE 1io6    SIGNALING PROTEIN 1ir3    COMPLEX (TRANSFERASE/SUBSTRATE) 1irk    TRANSFERASE (PHOSPHOTRANSFERASE) 1is0    TRANSFERASE 1jeg    TRANSFERASE/HYDROLASE 1jpa    TRANSFERASE 1jqh    TRANSFERASE 1jqq    PROTEIN TRANSPORT, MEMBRANE PROTEIN 1ju5    PROTEIN BINDING/TRANSFERASE 1k2p    TRANSFERASE 1k3a    TRANSFERASE 1k9a    TRANSFERASE 1ka6    IMMUNE SYSTEM 1ka7    IMMUNE SYSTEM 1kc2    TRANSFERASE 1kik    TRANSFERASE 1ksw    TRANSFERASE 1lck    COMPLEX (KINASE/PEPTIDE) 1luf    TRANSFERASE 1lui    TRANSFERASE 1luk    TRANSFERASE 1lum    TRANSFERASE 1lun    TRANSFERASE 1m14    TRANSFERASE 1m17    TRANSFERASE 1m27    SIGNALING PROTEIN, TRANSFERASE 1m30    PROTEIN BINDING 1m3a    PROTEIN BINDING 1m3b    PROTEIN BINDING 1m3c    PROTEIN BINDING 1m52    TRANSFERASE 1m7n    TRANSFERASE 1mqb    TRANSFERASE 1n5z    PROTEIN TRANSPORT 1nlo    COMPLEX (TRANSFERASE/PEPTIDE) 1nlp    COMPLEX (TRANSFERASE/PEPTIDE) 1nm7    PROTEIN TRANSPORT 1nyf    PHOSPHOTRANSFERASE 1nyg    PHOSPHOTRANSFERASE 1nzl    TRANSFERASE 1nzv    TRANSFERASE 1o41    SIGNALING PROTEIN 1o42    SIGNALING PROTEIN 1o43    SIGNALING PROTEIN 1o44    SIGNALING PROTEIN 1o45    SIGNALING PROTEIN 1o46    SIGNALING PROTEIN 1o47    SIGNALING PROTEIN 1o48    SIGNALING PROTEIN 1o49    SIGNALING PROTEIN 1o4a    SIGNALING PROTEIN 1o4b    SIGNALING PROTEIN 1o4c    SIGNALING PROTEIN 1o4d    SIGNALING PROTEIN 1o4e    SIGNALING PROTEIN 1o4f    SIGNALING PROTEIN 1o4g    SIGNALING PROTEIN 1o4h    SIGNALING PROTEIN 1o4i    SIGNALING PROTEIN 1o4j    SIGNALING PROTEIN 1o4k    SIGNALING PROTEIN 1o4l    SIGNALING PROTEIN 1o4m    SIGNALING PROTEIN 1o4n    SIGNALING PROTEIN 1o4o    SIGNALING PROTEIN 1o4p    SIGNALING PROTEIN 1o4q    SIGNALING PROTEIN 1o4r    SIGNALING PROTEIN 1oec    TRANSFERASE 1oot    STRUCTURAL GENOMICS 1opj    TRANSFERASE 1opk    TRANSFERASE 1opl    TRANSFERASE 1p13    TRANSFERASE 1p14    TRANSFERASE 1p4o    HORMONE/GROWTH FACTOR 1pic    COMPLEX (PHOSPHOTRANSFERASE/RECEPTOR) 1pkg    TRANSFERASE ACTIVATOR 1prl    COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) 1prm    COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) 1qcf    TYROSINE KINASE 1qly    TYROSINE-PROTEIN KINASE 1qpc    TRANSFERASE 1qpd    TRANSFERASE 1qpe    TRANSFERASE 1qpj    TRANSFERASE 1qwe    COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) 1qwf    COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) 1r0p    TRANSFERASE 1r1p    PEPTIDE BINDING PROTEIN 1r1q    PEPTIDE BINDING PROTEIN 1r1s    PEPTIDE BINDING PROTEIN 1r1w    TRANSFERASE 1rja    TRANSFERASE 1rjb    TRANSFERASE 1rlp    COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) 1rlq    COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) 1rqq    TRANSFERASE/SIGNALING PROTEIN 1sha    PHOSPHOTRANSFERASE 1shb    PHOSPHOTRANSFERASE 1shd    COMPLEX(TRANSFERASE/PEPTIDE) 1shf    PHOSPHOTRANSFERASE 1skj    TYROSINE-PROTEIN KINASE 1sm2    TRANSFERASE 1snu    TRANSFERASE 1snx    TRANSFERASE 1spr    TRANSFERASE(PHOSPHOTRANSFERASE) 1sps    TRANSFERASE(PHOSPHOTRANSFERASE) 1srl    PHOSPHOTRANSFERASE 1srm    PHOSPHOTRANSFERASE 1ssh    CONTRACTILE PROTEIN 1t45    TRANSFERASE ACTIVATOR 1t46    TRANSFERASE ACTIVATOR 1u46    TRANSFERASE 1u4d    TRANSFERASE 1u54    TRANSFERASE 1u59    TRANSFERASE 1uue    SH3-DOMAIN 1uwh    KINASE 1uwj    KINASE 1vr2    TRANSFERASE 1w1f    SH3-DOMAIN 1wa7    SH3 DOMAIN 1wxb    STRUCTURAL GENOMICS, UNKNOWN FUNCTION 1x27    SIGNALING PROTEIN 1x2k    SIGNALING PROTEIN 1xba    TRANSFERASE 1xbb    TRANSFERASE 1xbc    TRANSFERASE 1xkk    TRANSFERASE 1y57    TRANSFERASE 1y6a    TRANSFERASE 1y6b    TRANSFERASE 1yi6    TRANSFERASE 1yn8    UNKNOWN FUNCTION 1ynz    PROTEIN BINDING 1yoj    TRANSFERASE 1yol    TRANSFERASE 1yom    TRANSFERASE 1yvj    TRANSFERASE 1ywn    TRANSFERASE 1z3k    STRUCTURAL GENOMICS, UNKNOWN FUNCTION 1zbj    TRANSFERASE 1zlm    SIGNALING PROTEIN 1zx6    PROTEIN BINDING 2abl    TRANSFERASE 2auh    TRANSFERASE/SIGNALING PROTEIN 2b7a    TRANSFERASE 2b86    SIGNALING PROTEIN 2bdf    TRANSFERASE 2bdj    TRANSFERASE 2c0i    TRANSFERASE 2c0o    TRANSFERASE 2c0t    TRANSFERASE 2ci8    SH2-DOMAIN 2ci9    SH2-DOMAIN/COMPLEX 2cia    SH2-DOMAIN 2cub    SIGNALING PROTEIN 2d8j    TRANSFERASE 2dl4    SIGNALING PROTEIN 2dly    TRANSFERASE 2dm0    TRANSFERASE 2dq7    TRANSFERASE 2e2b    TRANSFERASE 2e6i    TRANSFERASE 2eb2    TRANSFERASE 2eb3    TRANSFERASE 2ecd    SIGNALING PROTEIN 2ekx    SIGNALING PROTEIN 2eo6    SIGNALING PROTEIN 2etz    TRANSFERASE 2eu0    TRANSFERASE 2eyw    SIGNALING PROTEIN 2f4j    TRANSFERASE 2fb8    TRANSFERASE 2fei    STRUCTURAL PROTEIN 2fgi    TRANSFERASE 2fo0    TRANSFERASE 2frw    PROTEIN BINDING 2g15    TRANSFERASE 2g1t    TRANSFERASE 2g2f    TRANSFERASE 2g2h    TRANSFERASE 2g2i    TRANSFERASE 2ge9    TRANSFERASE 2gqg    TRANSFERASE 2gs2    TRANSFERASE 2gs6    TRANSFERASE 2gs7    TRANSFERASE 2gsf    TRANSFERASE 2h8h    TRANSFERASE 2hck    TRANSFERASE 2hda    TRANSFERASE 2hel    SIGNALING PROTEIN, TRANSFERASE 2hen    TRANSFERASE 2hiw    TRANSFERASE 2hk5    TRANSFERASE 2hwo    TRANSFERASE 2hwp    TRANSFERASE 2hyy    TRANSFERASE 2hz0    TRANSFERASE 2hz4    TRANSFERASE 2hzi    TRANSFERASE 2hzn    TRANSFERASE 2i0v    TRANSFERASE 2i0y    TRANSFERASE 2i1m    TRANSFERASE 2iim    SIGNALING PROTEIN 2itn    TRANSFERASE 2ito    TRANSFERASE 2itp    TRANSFERASE 2itq    TRANSFERASE 2itt    TRANSFERASE 2itu    TRANSFERASE 2itv    TRANSFERASE 2itw    TRANSFERASE 2itx    TRANSFERASE 2ity    TRANSFERASE 2itz    TRANSFERASE 2iui    TRANSFERASE 2ivs    TRANSFERASE 2ivu    TRANSFERASE 2j5e    TRANSFERASE 2j5f    TRANSFERASE 2j6m    TRANSFERASE 2jit    TRANSFERASE 2jiu    TRANSFERASE 2jiv    TRANSFERASE 2js0    SIGNALING PROTEIN 2js2    SIGNALING PROTEIN 2jxb    SIGNALING PROTEIN COMPLEX 2jyq    TRANSFERASE 2of2    TRANSFERASE 2of4    TRANSFERASE 2ofu    TRANSFERASE 2ofv    TRANSFERASE 2og8    TRANSFERASE 2ogv    TRANSFERASE 2oh4    TRANSFERASE 2oi3    TRANSFERASE 2oiq    TRANSFERASE 2oj2    SIGNALING PROTEIN,TRANSFERASE/INHIBITOR 2oj9    TRANSFERASE 2oo8    TRANSFERASE 2osc    TRANSFERASE 2ozo    TRANSFERASE 2p0c    TRANSFERASE 2p2h    TRANSFERASE 2p2i    TRANSFERASE 2p4i    TRANSFERASE 2pl0    TRANSFERASE 2psq    TRANSFERASE 2ptk    TYROSINE-PROTEIN KINASE 2pvf    TRANSFERASE 2pvy    TRANSFERASE 2pwl    TRANSFERASE 2py3    TRANSFERASE 2pz5    TRANSFERASE 2pzp    TRANSFERASE 2pzr    TRANSFERASE 2q0b    TRANSFERASE 2qi8    SIGNALING PROTEIN, TRANSFERASE 2qlq    TRANSFERASE 2qo2    TRANSFERASE 2qo7    TRANSFERASE 2qo9    TRANSFERASE 2qob    TRANSFERASE 2qoc    TRANSFERASE 2qod    TRANSFERASE 2qof    TRANSFERASE 2qoh    TRANSFERASE 2qoi    TRANSFERASE 2qok    TRANSFERASE 2qol    TRANSFERASE 2qon    TRANSFERASE 2qoo    TRANSFERASE 2qoq    TRANSFERASE 2qq7    TRANSFERASE 2qu5    TRANSFERASE 2qu6    TRANSFERASE 2r2p    TRANSFERASE 2r4b    TRANSFERASE 2rei    TRANSFERASE 2rf9    TRANSFERASE 2rfd    TRANSFERASE 2rfe    TRANSFERASE 2rfn    TRANSFERASE 2rfs    TRANSFERASE 2rgp    TRANSFERASE 2rl5    TRANSFERASE 2rn8    TRANSFERASE 2rna    TRANSFERASE 2src    TYROSINE-PROTEIN KINASE 2v1r    PROTEIN TRANSPORT 2v7a    TRANSFERASE 2vkn    MEMBRANE PROTEIN 2vwu    TRANSFERASE 2vwv    TRANSFERASE 2vww    TRANSFERASE 2vwx    TRANSFERASE 2vwy    TRANSFERASE 2vwz    TRANSFERASE 2vx0    TRANSFERASE 2vx1    TRANSFERASE 2w1i    TRANSFERASE 2ys2    TRANSFERASE 2yt6    CELL CYCLE 2yuq    TRANSFERASE 2z0p    SIGNALING PROTEIN 2z60    TRANSFERASE 2z8c    TRANSFERASE 2zm1    TRANSFERASE 2zm3    TRANSFERASE 2zm4    TRANSFERASE 2zv7    TRANSFERASE 2zv8    TRANSFERASE 2zv9    TRANSFERASE 2zva    TRANSFERASE 2zyb    TRANSFERASE 3b2t    TRANSFERASE 3b2w    TRANSFERASE 3b8q    TRANSFERASE 3b8r    TRANSFERASE 3bbt    TRANSFERASE 3bbw    TRANSFERASE 3bce    TRANSFERASE 3be2    TRANSFERASE 3bea    TRANSFERASE 3bel    TRANSFERASE 3bkb    TRANSFERASE 3bpr    TRANSFERASE 3brb    TRANSFERASE 3bu3    TRANSFERASE 3bu5    TRANSFERASE 3bu6    TRANSFERASE 3bym    TRANSFERASE 3byo    TRANSFERASE 3bys    TRANSFERASE 3byu    TRANSFERASE 3bz3    TRANSFERASE 3c1x    TRANSFERASE 3c4c    TRANSFERASE 3c4d    TRANSFERASE 3c4f    TRANSFERASE 3c7q    TRANSFERASE 3cbl    TRANSFERASE 3cc6    TRANSFERASE 3ccn    TRANSFERASE 3cd3    TRANSFERASE 3cd8    TRANSFERASE 3ce3    TRANSFERASE 3cjf    TRANSFERASE 3cjg    TRANSFERASE 3cly    TRANSFERASE 3cp9    TRANSFERASE 3cpb    TRANSFERASE 3cpc    TRANSFERASE 3cqt    TRANSFERASE 3cs9    TRANSFERASE 3cth    TRANSFERASE 3ctj    TRANSFERASE 3d4q    TRANSFERASE 3d7t    TRANSFERASE 3d7u    TRANSFERASE 3d94    TRANSFERASE 3dk3    TRANSFERASE 3dk6    TRANSFERASE 3dk7    TRANSFERASE 3dko    TRANSFERASE 3dqw    TRANSFERASE 3dqx    TRANSFERASE 3dtw    TRANSFERASE 3dzq    TRANSFERASE 3e62    TRANSFERASE 3e63    TRANSFERASE 3e64    TRANSFERASE 3efj    TRANSFERASE 3efk    TRANSFERASE 3ekk    TRANSFERASE 3ekn    TRANSFERASE 3el7    TRANSFERASE 3el8    TRANSFERASE 3emg    TRANSFERASE 3en4    TRANSFERASE 3en5    TRANSFERASE 3en6    TRANSFERASE 3en7    TRANSFERASE 3eqp    TRANSFERASE 3eqr    TRANSFERASE 3eyg    TRANSFERASE 3eyh    TRANSFERASE 3f5p    TRANSFERASE 3f66    TRANSFERASE 3f6x    TRANSFERASE 3fup    TRANSFERASE 3fxx    TRANSFERASE 3fy2    TRANSFERASE 3hck    TRANSFERASE 3lck    TYROSINE-PROTEIN KINASE 4hck    TRANSFERASE 5hck    TRANSFERASE PSSH: ID    Description Q572P5    UNKNOWN Q572P1    UNKNOWN Q572P3    UNKNOWN Q5JY90    UNKNOWN Q9NPI2    UNKNOWN Q9NPI3    UNKNOWN Q9P0L4    UNKNOWN Q9P0M0    UNKNOWN Q9P0L7    UNKNOWN Q9P0L6    UNKNOWN Q9P0L5    UNKNOWN Q9P0L3    UNKNOWN Q9P0L8    UNKNOWN Q06187    UNKNOWN Q3MS88    UNKNOWN Q3MS93    UNKNOWN Q3MS96    UNKNOWN Q3MS94    UNKNOWN Q3MS87    UNKNOWN Q3MS95    UNKNOWN Q3MS92    UNKNOWN Q3MS89    UNKNOWN
Diseases	OMIM: OMIM ID    Name    Alt Name 300300    BRUTON AGAMMAGLOBULINEMIA TYROSINE KINASE; BTK    AGAMMAGLOBULINEMIA TYROSINE KINASE; ATK B-CELL PROGENITOR KINASE; BPK
Gene Ontology	GO: GO ID    Description GO:0000166    nucleotide binding GO:0004672    protein kinase activity GO:0004674    protein serine/threonine kinase activity GO:0004713    protein tyrosine kinase activity GO:0004715    non-membrane spanning protein tyrosine kinase activity GO:0005515    protein binding GO:0005524    ATP binding GO:0005634    nucleus GO:0005737    cytoplasm GO:0006468    protein amino acid phosphorylation GO:0007242    intracellular signaling cascade GO:0007249    I-kappaB kinase/NF-kappaB cascade GO:0007498    mesoderm development GO:0008270    zinc ion binding GO:0008624    induction of apoptosis by extracellular signals GO:0016020    membrane GO:0016301    kinase activity GO:0016740    transferase activity GO:0018108    peptidyl-tyrosine phosphorylation GO:0019722    calcium-mediated signaling GO:0031410    cytoplasmic vesicle GO:0042802    identical protein binding GO:0045121    membrane raft GO:0046872    metal ion binding GO:0048469    cell maturation
Pathway	KEGG: KEGG PATHWAY ID    Name hsa04662    B cell receptor signaling pathway hsa04664    Fc epsilon RI signaling pathway hsa05340    Primary immunodeficiency Panther: ID    Description P00010    B cell activation
Chemicals	DrugBank: ID    Name    Synonyms DB03265    Inositol-(1,3,4,5)-Tetrakisphosphate    DB01863    Inositol 1,3,4,5-Tetrakisphosphate    HMDB: ID    Name    Synonyms
Orthology	Orthology Relations: Gene Gene Description Organism Orthology type Orthologs Orthologs Description ENSG00000010671 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187] Pan_troglodytes one2one ENSPTRG00000022104 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]BTK Pongo_pygmaeus one2one ENSPPYG00000020552 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Macaca_mulatta one2one ENSMMUG00000019573 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Equus_caballus one2one ENSECAG00000020984 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]LOC100057626 Tarsius_syrichta one2one ENSTSYG00000009216 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Otolemur_garnettii one2one ENSOGAG00000004545 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Myotis_lucifugus one2one ENSMLUG00000004336 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Tursiops_truncatus one2one ENSTTRG00000012776 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Felis_catus one2one ENSFCAG00000015395 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Pteropus_vampyrus one2one ENSPVAG00000001567 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Canis_familiaris one2one ENSCAFG00000017669 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]BTK Microcebus_murinus one2one ENSMICG00000015601 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Oryctolagus_cuniculus one2one ENSOCUG00000010621 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Bos_taurus one2one ENSBTAG00000019250 Bruton agammaglobulinemia tyrosine kinase [Source:RefSeq_peptide;Acc:NP_001029761][hgnc]BTK Dasypus_novemcinctus one2one ENSDNOG00000015948 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Spermophilus_tridecemlineatus one2one ENSSTOG00000004722 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Cavia_porcellus one2one ENSCPOG00000000549 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Dipodomys_ordii one2one ENSDORG00000009983 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Kinase EMB) [Source:UniProtKB/Swiss-Prot;Acc:P35991][hgnc] Echinops_telfairi one2one ENSETEG00000008404 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Sorex_araneus one2one ENSSARG00000014162 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Erinaceus_europaeus one2one ENSEEUG00000015649 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Mus_musculus one2one ENSMUSG00000031264 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) (Kinase EMB) [Source:UniProtKB/Swiss-Prot;Acc:P35991][hgnc]Btk Rattus_norvegicus one2one ENSRNOG00000011331 Bruton agammaglobulinemia tyrosine kinase [Source:RefSeq_peptide;Acc:NP_001007799][hgnc]Btk Monodelphis_domestica one2one ENSMODG00000011651 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc] Ornithorhynchus_anatinus one2one ENSOANG00000004224 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase) (Agammaglobulinaemia tyrosine kinase) (ATK) (B-cell progenitor kinase) (BPK) [Source:UniProtKB/Swiss-Prot;Acc:Q06187][hgnc]100080912 Gallus_gallus one2one ENSGALG00000004958 Tyrosine-protein kinase BTK (EC 2.7.10.2) (Bruton tyrosine kinase). [Source:UniProtKB/Swiss-Prot;Acc:Q8JH64][hgnc]BTK