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Summary sheet information for Effector 'Rap1GAPII-Homo sapiens-1'
Name Rap1GAPII-Homo sapiens-1
Description RecName: Full=Rap1 GTPase-activating protein 1; Short=Rap1GAP1; Short=Rap1GAP
Class
Family GTPase activating proteins
Sub_family Rap-specific GAPs
type Rap1GAPII
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 1
Gene Start: 21795302
Gene End: 21868390
Ensembl Contig View
Ensembl Genes:
ENSG00000076864
EMBL:
EMBL ID  Description
AB003930  Homo sapiens mRNA for rap1GAPII, partial cds.
AB007943  Homo sapiens mRNA for KIAA0474 protein, partial cds.
AL359815  Human DNA sequence from clone RP11-63N8 on chromosome 1 Contains the 3' end of the ALPL gene for alkaline phosphatase, liver/bone/kidney, the RAP1GA1 gene for RAP1, GTPase activating protein 1, a novel gene, the 3' end of the USP31 gene for ubiquitin specific protease 31 and a CpG island.
BC035030  Homo sapiens RAP1 GTPase activating protein, mRNA (cDNA clone MGC:33806 IMAGE:5261027), complete cds.
BC054490  Homo sapiens RAP1 GTPase activating protein, mRNA (cDNA clone MGC:51934 IMAGE:5767775), complete cds.
CH471134  Homo sapiens 211000035839713 genomic scaffold, whole genome shotgun sequence.
M64788  Human GTPase activating protein (rap1GAP) mRNA, complete cds.

EntrezGene:
ID  Description
RAP1GAP  RAP1 GTPase activating protein
RefSeq DNA:
ID  Description
NM_002885  Homo sapiens RAP1 GTPase activating protein (RAP1GAP), mRNA.

UniGene:
ID  Description
Hs.148178  RAP1 GTPase activating protein, mRNA (cDNA clone MGC:33806 IMAGE:5261027)

Proteins
Ensembl Proteins:
ENSP00000363889; ENSP00000363904; ENSP00000363890; ENSP00000290101; ENSP00000352739; ENSP00000315420; ENSP00000363895; ENSP00000363893; ENSP00000363897
Entrez Proteins:
AAA60252.1; AAH35030.1; AAH54490.1; BAA32319.3; BAA83674.1; CAI16250.1; CAI16253.1; CAI16254.1; CAI16255.1; CAI16257.1; CAI16258.1; EAW94980.1
RefSeq Proteins:
ID  Description
NP_002876  RAP1 GTPase activating protein [Homo sapiens].

UniProt:
ID  Description
A8MPS8  SubName: Full=Putative uncharacterized protein RAP1GAP;
O75062  UNKNOWN
Q49AP2  SubName: Full=RAP1GAP protein;
Q5T3S6  SubName: Full=RAP1 GTPase activating protein; Flags: Fragment;
Q5T3S7  SubName: Full=RAP1 GTPase activating protein;
Q5T3S9  SubName: Full=RAP1 GTPase activating protein;
Q5T3T0  SubName: Full=RAP1 GTPase activating protein; Flags: Fragment;
Q5T3T1  SubName: Full=RAP1 GTPase activating protein; Flags: Fragment;
Q5T3T4  UNKNOWN
Q7Z5S8  SubName: Full=RAP1 GTPase activating protein;
Q9UQ51  SubName: Full=Rap1GAPII; Flags: Fragment;
P47736  RecName: Full=Rap1 GTPase-activating protein 1; Short=Rap1GAP1; Short=Rap1GAP;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Rap1GAPII-Homo sapiens-1    

InterPro:
ID  Name
IPR003109  GoLoco_motif
IPR000331  Rap_GAP
Pfam:
ID  Description
Rap_GAP  Rap/ran-GAP
GoLoco  GoLoco motif

Structure
PDB:
ID
1SRQ
3BRW
HSSP:
ID  Description
1srq  SIGNALING PROTEIN
3brw  GTP BINDING PROTEIN
PSSH:
ID  Description
Diseases
OMIM:
OMIM ID  Name  Alt Name
600278  RAP1, GTPase-ACTIVATING PROTEIN 1; RAP1GA1   GTPase-ACTIVATING PROTEIN, RAP1, 1; RAP1GAP
Gene Ontology
GO:
GO ID  Description
GO:0000139  Golgi membrane
GO:0003924  GTPase activity
GO:0005096  GTPase activator activity
GO:0005622  intracellular
GO:0005624  membrane fraction
GO:0005794  Golgi apparatus
GO:0005829  cytosol
GO:0007165  signal transduction
GO:0016020  membrane
GO:0051056  regulation of small GTPase mediated signal transduction
Pathway
KEGG:
KEGG PATHWAY ID  Name
Panther:
ID  Description
P00027  Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Chemicals
DrugBank:
ID  Name  Synonyms
DB03684  2-Methyl-2,4-Pentanediol  
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000076864 Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736] Pan_troglodytesone2one ENSPTRG00000000303Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Macaca_mulattaone2one ENSMMUG00000002218Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Microcebus_murinusone2one ENSMICG00000013741Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Otolemur_garnettiione2one ENSOGAG00000011255Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Loxodonta_africanaone2one ENSLAFG00000007354Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Felis_catusone2one ENSFCAG00000002961Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Canis_familiarisone2one ENSCAFG00000014844Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]LOC487387
Pteropus_vampyrusone2one ENSPVAG00000000630Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Tursiops_truncatusone2one ENSTTRG00000001997Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Cavia_porcellusone2one ENSCPOG00000024422Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Ochotona_princepsone2one ENSOPRG00000008131Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Bos_taurusone2one ENSBTAG00000008952hypothetical protein LOC532839 [Source:RefSeq_peptide;Acc:NP_001070356][hgnc]RAP1GAP
Myotis_lucifugusone2one ENSMLUG00000001975Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Procavia_capensisone2one ENSPCAG00000004496Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000010278Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Tupaia_belangerione2one ENSTBEG00000004460Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Echinops_telfairione2one ENSETEG00000002219Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Sorex_araneusone2one ENSSARG00000012680Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Dipodomys_ordiione2one ENSDORG00000001399Rap1 GTPase-activating protein [Source:RefSeq_peptide;Acc:NP_001074624][hgnc]
Equus_caballusone2one ENSECAG00000022900Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Rattus_norvegicusone2one ENSRNOG00000013825Rap1ga1 protein (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q5EB70][hgnc]
Mus_musculusone2one ENSMUSG00000041351Rap1 GTPase-activating protein [Source:RefSeq_peptide;Acc:NP_001074624][hgnc]Rap1gap
Ornithorhynchus_anatinusone2one ENSOANG00000005926Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]100087082
Pongo_pygmaeusone2one ENSPPYG00000001759Putative uncharacterized protein DKFZp459H027. [Source:UniProtKB/TrEMBL;Acc:Q5R6B3][hgnc]
Xenopus_tropicalisapprent_one2one ENSXETG00000017936Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Monodelphis_domesticaone2one ENSMODG00000016010Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Danio_rerioone2many ENSDARG00000056554[hgnc]LOC555359
Oryzias_latipesone2many ENSORLG00000007499Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Takifugu_rubripesone2many ENSTRUG00000014029Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000004819Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000012353Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Takifugu_rubripesone2many ENSTRUG00000018101Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Oryzias_latipesone2many ENSORLG00000013991Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000018303Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000019473Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Danio_rerioone2many ENSDARG00000053272Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Gallus_gallusapprent_one2one ENSGALG00000014701Rap1 GTPase-activating protein 1 (Rap1GAP1) (Rap1GAP) [Source:UniProtKB/Swiss-Prot;Acc:P47736][hgnc]
Ciona_savignyione2many ENSCSAVG00000010331[hgnc]
Ciona_intestinalisone2many ENSCING00000001624[hgnc]