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Summary sheet information for Effector 'Adenylate cyclase 2-Homo sapiens'
Name Adenylate cyclase 2-Homo sapiens
Description RecName: Full=Adenylate cyclase type 2; EC=4.6.1.1;AltName: Full=Adenylate cyclase type II;AltName: Full=ATP pyrophosphate-lyase 2;AltName: Full=Adenylyl cyclase 2
Class
Family Cyclases
Sub_family Adenylate cyclases
type Adenylate cyclase 2
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 5
Gene Start: 7449343
Gene End: 7883194
Ensembl Contig View
Ensembl Genes:
ENSG00000078295
EMBL:
EMBL ID  Description
AB028983  Homo sapiens mRNA for KIAA1060 protein, partial cds.
AF070583  Homo sapiens clone 24648 adenylyl cyclase mRNA, partial cds.
AF410885  Homo sapiens adenylyl cyclase type II mRNA, complete cds.
BC111743  Homo sapiens adenylate cyclase 2 (brain), mRNA (cDNA clone MGC:133314 IMAGE:40038765), complete cds.
BK000372  TPA: Homo sapiens adenylyl cyclase type II (ADCY2) mRNA, partial cds.
CR749634  Homo sapiens mRNA; cDNA DKFZp686J099 (from clone DKFZp686J099)
L21993  Human adenylyl cyclase mRNA, 3' end of cds.
X74210  H.sapiens mRNA for adenylyl cyclase

EntrezGene:
ID  Description
ADCY2  adenylate cyclase 2 (brain)
LOC100133953  similar to adenylate cyclase 2
RefSeq DNA:
ID  Description
NM_020546  Homo sapiens adenylate cyclase 2 (brain) (ADCY2), mRNA.
XM_001717432  PREDICTED: Homo sapiens similar to adenylate cyclase 2 (LOC100133953), mRNA.

UniGene:
ID  Description
Proteins
Ensembl Proteins:
ENSP00000371972; ENSP00000371971; ENSP00000342952
Entrez Proteins:
AAA64923.1; AAC28647.1; AAI11744.1; AAP97285.1; BAA83012.1; CAA52282.1; CAH18428.1; DAA00058.1
RefSeq Proteins:
ID  Description
NP_065433  adenylate cyclase 2 [Homo sapiens].
XP_001717484  PREDICTED: similar to adenylate cyclase 2 [Homo sapiens].

UniProt:
ID  Description
Q68D02  SubName: Full=Putative uncharacterized protein DKFZp686J099; Flags: Fragment;
Q71UM8  SubName: Full=Adenylyl cyclase; Flags: Fragment;
Q7RTV6  SubName: Full=Adenylyl cyclase type II; Flags: Fragment;
Q9UDB2  SubName: Full=Type II adenylyl cyclase; EC=4.6.1.1; Flags: Fragment;
Q08462  RecName: Full=Adenylate cyclase type 2; EC=4.6.1.1; AltName: Full=Adenylate cyclase type II; AltName: Full=ATP pyrophosphate-lyase 2; AltName: Full=Adenylyl cyclase 2;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Adenylate cyclase 2-Homo sapiens    

InterPro:
ID  Name
IPR001054  A/G_cyclase
IPR009398  Aden_cycl_like
Pfam:
ID  Description
Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
DUF1053  Domain of Unknown Function (DUF1053)

Structure
PDB:
ID
HSSP:
ID  Description
1ab8  LYASE
1azs  COMPLEX (LYASE/HYDROLASE)
1cjk  LYASE/LYASE/SIGNALING PROTEIN
1cjt  LYASE/LYASE/SIGNALING PROTEIN
1cju  LYASE/LYASE/SIGNALING PROTEIN
1cjv  LYASE/LYASE/SIGNALING PROTEIN
1cs4  LYASE/LYASE/SIGNALING PROTEIN
1cul  LYASE/LYASE/SIGNALING PROTEIN
1tl7  LYASE
1u0h  LYASE
1yk9  LYASE
2gvd  LYASE
2gvz  LYASE
3c14  LYASE/LYASE INHIBITOR
3c15  LYASE/LYASE INHIBITOR
3c16  LYASE/LYASE INHIBITOR
3et6  LYASE
PSSH:
ID  Description
Q68D02  UNKNOWN
Q71UM8  UNKNOWN
Q9UDB2  UNKNOWN
Q08462  UNKNOWN
Diseases
OMIM:
OMIM ID  Name  Alt Name
103071  ADENYLATE CYCLASE 2; ADCY2   ADENYLYL CYCLASE 2 ADENYLYL CYCLASE, BRAIN, TYPE II
Gene Ontology
GO:
GO ID  Description
GO:0000287  magnesium ion binding
GO:0004016  adenylate cyclase activity
GO:0006171  cAMP biosynthetic process
GO:0007242  intracellular signaling cascade
GO:0009190  cyclic nucleotide biosynthetic process
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0016849  phosphorus-oxygen lyase activity
GO:0030425  dendrite
Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa04062  Chemokine signaling pathway
hsa05414  Dilated cardiomyopathy
hsa04540  Gap junction
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa00230  Purine metabolism
hsa04270  Vascular smooth muscle contraction

Panther:
ID  Description
P05916  Opioid prodynorphin pathway
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P05731  GABA-B receptor II signaling
P04379  Beta3 adrenergic receptor signaling pathway
P04376  5HT4 type receptor mediated signaling pathway
P04386  Histamine H2 receptor mediated signaling pathway
P05912  Dopamine receptor mediated signaling pathway
P00019  Endothelin signaling pathway
P04377  Beta1 adrenergic receptor signaling pathway
P00031  Inflammation mediated by chemokine and cytokine signaling pathway
P04378  Beta2 adrenergic receptor signaling pathway
P05913  Enkephalin release
P04373  5HT1 type receptor mediated signaling pathway
P05915  Opioid proenkephalin pathway
P05917  Opioid proopiomelanocortin pathway
Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
HMDB00538   Adenosine triphosphate   5'-(tetrahydrogen triphosphate) Adenosine; 5'-ATP; ATP; Adenosine 5'-triphosphate; Adenosine 5'-triphosphorate; Adenosine 5'-triphosphoric acid; Adenosine triphosphate; Adenosine triphosphic acid; Adenylpyrophosphorate; Adenylpyrophosphoric acid; Adephos; Adetol; Adynol; Atipi; Atriphos; Cardenosine; Fosfobion; Glucobasin; Myotriphos; Phosphobion; Striadyne; Triadenyl; Triphosphaden; Triphosphoric acid adenosine ester
HMDB00058   Cyclic AMP   Cyclic AMP; 3'5'-cyclic AMP; 6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide; Acrasin; Adenosine 3',5'-cyclic monophosphate; Adenosine 3',5'-cyclic phosphate; Adenosine 3',5'-cyclophosphate; Adenosine 3',5'-monophosphate; Adenosine 3,5'-cyclic monophosphorate; Adenosine 3,5'-cyclic monophosphoric acid; Adenosine cyclic monophosphate; Cyclic 3',5'-AMP; Cyclic 3',5'-adenylate; Cyclic 3',5'-adenylic acid; Cyclic adenosine 3',5'-phosphate; adenosine cyclic-monophosphate; adenosine-cyclic-phosphate; adenosine-cyclic-phosphoric-acid; cAMP
HMDB00250   Pyrophosphate   (4-)Diphosphoric acid ion; (P2O74-)Diphosphate; Diphosphate; Pyrometaphosphate; Pyrophosphate; Pyrophosphate tetraanion; Pyrophosphate(4-) ion; Pyrophosphic acid
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000078295 Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462] Canis_familiarisone2one ENSCAFG00000010238Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]ADCY2
Pan_troglodytesone2one ENSPTRG00000016718Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]ADCY2
Macaca_mulattaone2one ENSMMUG00000018742Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000015335Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000000223Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Otolemur_garnettiione2one ENSOGAG00000001027Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Microcebus_murinusone2one ENSMICG00000002952Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Equus_caballusone2one ENSECAG00000016266Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Myotis_lucifugusone2one ENSMLUG00000013498Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Felis_catusone2one ENSFCAG00000015101Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Cavia_porcellusone2one ENSCPOG00000010781Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Bos_taurusone2one ENSBTAG00000019210Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]ADCY2
Dipodomys_ordiione2one ENSDORG00000010924Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q80TL1][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000008557Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Vicugna_pacosone2one ENSVPAG00000001790Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000011573Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Ochotona_princepsone2one ENSOPRG00000008293Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Tursiops_truncatusone2one ENSTTRG00000004318Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000011164Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Mus_musculusone2one ENSMUSG00000021536Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q80TL1][hgnc]Adcy2
Tupaia_belangerione2one ENSTBEG00000014208Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Loxodonta_africanaone2one ENSLAFG00000004954Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Rattus_norvegicusone2one ENSRNOG00000032150Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2). [Source:UniProtKB/Swiss-Prot;Acc:P26769][hgnc]Adcy2
Erinaceus_europaeusone2one ENSEEUG00000014509Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000004851Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Procavia_capensisone2one ENSPCAG00000008910Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Monodelphis_domesticaone2one ENSMODG00000002081Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Gallus_gallusone2one ENSGALG00000013060Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]LOC771451
Ornithorhynchus_anatinusone2one ENSOANG00000011580Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]100089708
Echinops_telfairione2one ENSETEG00000006651Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Takifugu_rubripesone2many ENSTRUG00000004979Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000006520Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Danio_rerioone2many ENSDARG00000058392[hgnc]LOC792352
Danio_rerioone2many ENSDARG00000014588Novel protein similar to vertebrate adenylate cyclase 2 (Brain) (ADCY2) (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q1L8K1][hgnc]adcy2b
Tetraodon_nigroviridisone2many ENSTNIG00000009256Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Takifugu_rubripesone2many ENSTRUG00000012172Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000004420Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Oryzias_latipesone2one ENSORLG00000014400Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000008170Adenylate cyclase type 2 (EC 4.6.1.1) (Adenylate cyclase type II) (ATP pyrophosphate-lyase 2) (Adenylyl cyclase 2) [Source:UniProtKB/Swiss-Prot;Acc:Q08462][hgnc]