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Summary sheet information for Effector 'GRK3-Homo sapiens'
Name GRK3-Homo sapiens
Description RecName: Full=Beta-adrenergic receptor kinase 2; Short=Beta-ARK-2; EC=2.7.11.15;AltName: Full=G-protein-coupled receptor kinase 3
Class
Family Ser Thr protein kinases
Sub_family G protein coupled receptor kinases
type GRK3
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 22
Gene Start: 24290861
Gene End: 24455238
Ensembl Contig View
Ensembl Genes:
ENSG00000100077
EMBL:
EMBL ID  Description
AK292234  Homo sapiens cDNA FLJ77587 complete cds, highly similar to Homo sapiens adrenergic, beta, receptor kinase 2 (ADRBK2), mRNA.
AL022329  Human DNA sequence from clone CTA-407F11 on chromosome 22q12 Contains the ADRBK2 gene for adrenergic, beta, receptor kinase 2, a v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1 (YES1) pseudogene, the 5' end of the MYO18B gene for myosin XVIIIB, two novel genes and two CpG islands.
BC036797  Homo sapiens adrenergic, beta, receptor kinase 2, mRNA (cDNA clone MGC:46121 IMAGE:5590378), complete cds.
X69117  H.sapiens mRNA for beta-adrenergic kinase 2

EntrezGene:
ID  Description
ADRBK2  adrenergic, beta, receptor kinase 2
RefSeq DNA:
ID  Description
NM_005160  Homo sapiens adrenergic, beta, receptor kinase 2 (ADRBK2), mRNA.

UniGene:
ID  Description
Hs.604679  Transcribed locus
Hs.657494  CDNA clone IMAGE:5259924

Proteins
Ensembl Proteins:
ENSP00000317578
Entrez Proteins:
AAH36797.1; BAF84923.1; CAA48870.1; CAB45657.1
RefSeq Proteins:
ID  Description
NP_005151  beta-adrenergic receptor kinase 2 [Homo sapiens].

UniProt:
ID  Description
A8K869  SubName: Full=cDNA FLJ77587, highly similar to Homo sapiens adrenergic, beta, receptor kinase 2 (ADRBK2), mRNA;
Q8N433  SubName: Full=ADRBK2 protein;
P35626  RecName: Full=Beta-adrenergic receptor kinase 2; Short=Beta-ARK-2; EC=2.7.11.15; AltName: Full=G-protein-coupled receptor kinase 3;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     GRK3-Homo sapiens    

InterPro:
ID  Name
IPR017442  Se/Thr_pkinase-rel
IPR000719  Prot_kinase_core
IPR000342  Regulat_G_prot_signal
IPR000961  Pkinase_C
IPR011993  PH_type
IPR017441  Protein_kinase_ATP_bd_CS
IPR015743  BARK
IPR002290  Ser_thr_pkinase
IPR000239  GPCR_kinase
IPR001849  Pleckstrin_homology
IPR008271  Ser_thr_pkin_AS
Pfam:
ID  Description
Pkinase  Protein kinase domain
PH  PH domain
RGS  Regulator of G protein signaling domain

Structure
PDB:
ID
HSSP:
ID  Description
1bak  TRANSFERASE
1gzk  KINASE
1gzn  KINASE
1gzo  KINASE
1h1w  TRANSFERASE
1mrv  TRANSFERASE
1mry  TRANSFERASE
1o6k  TRANSFERASE
1o6l  TRANSFERASE
1omw  TRANSFERASE
1uvr  TRANSFERASE
1vzo  TRANSFERASE
1ym7  TRANSFERASE
2acx  TRANSFERASE
2bcj  TRANSFERASE/HYDROLASE
2i0e  TRANSFERASE
2jdo  TRANSFERASE
2jdr  TRANSFERASE
2r5t  TRANSFERASE
2uw9  TRANSFERASE/INHIBITOR COMPLEX
2z7q  TRANSFERASE
2z7r  TRANSFERASE
2z7s  TRANSFERASE
3c4w  TRANSFERASE
3c4x  TRANSFERASE
3c4y  TRANSFERASE
3c4z  TRANSFERASE
3c50  TRANSFERASE
3c51  TRANSFERASE
3cqu  TRANSFERASE
3cqw  TRANSFERASE
3d0e  TRANSFERASE INHIBITOR
3e87  TRANSFERASE
3e88  TRANSFERASE
3e8d  TRANSFERASE
PSSH:
ID  Description
Q8N433  UNKNOWN
P35626  UNKNOWN
Diseases
OMIM:
OMIM ID  Name  Alt Name
109636  BETA-ADRENERGIC RECEPTOR KINASE 2; ADRBK2   BARK2 GRK3
Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0004672  protein kinase activity
GO:0004674  protein serine/threonine kinase activity
GO:0004703  G-protein coupled receptor kinase activity
GO:0004713  protein tyrosine kinase activity
GO:0004871  signal transducer activity
GO:0005524  ATP binding
GO:0006468  protein amino acid phosphorylation
GO:0007165  signal transduction
GO:0016740  transferase activity
GO:0047696  beta-adrenergic receptor kinase activity
Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04062  Chemokine signaling pathway
hsa04144  Endocytosis
hsa04740  Olfactory transduction

Panther:
ID  Description
P05911  Angiotensin II-stimulated signaling through G proteins and beta-arrestin
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00049  Parkinson disease
Chemicals
DrugBank:
ID  Name  Synonyms
DB00171  Adenosine triphosphate  5'-ATP; ATP; Adenosine 5'-triphosphate; Adenosine 5'-triphosphoric acid; Adenosine, 5'-(tetrahydrogen triphosphate); Adenosine-5'-triphosphate; Adenylpyrophosphoric acid; Triphosphoric acid adenosine ester
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000100077 Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626] Pan_troglodytesone2one ENSPTRG00000014187Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000011659Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Macaca_mulattaone2one ENSMMUG00000023790Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Tupaia_belangerione2one ENSTBEG00000016905Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000007859Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Microcebus_murinusone2one ENSMICG00000011174Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000017638Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000008132Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Otolemur_garnettiione2one ENSOGAG00000003448Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Equus_caballusone2one ENSECAG00000019326Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]LOC100065495
Tursiops_truncatusone2one ENSTTRG00000000480Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Loxodonta_africanaone2one ENSLAFG00000014476Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Felis_catusone2one ENSFCAG00000009926Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Vicugna_pacosone2one ENSVPAG00000004131Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Sorex_araneusone2one ENSSARG00000002046Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Cavia_porcellusone2one ENSCPOG00000009793Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Procavia_capensisone2one ENSPCAG00000012748Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Bos_taurusone2one ENSBTAG00000000005Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G- protein-coupled receptor kinase 3). [Source:UniProtKB/Swiss-Prot;Acc:P26818][hgnc]ADRBK2
Ochotona_princepsone2one ENSOPRG00000014637Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Canis_familiarisone2one ENSCAFG00000011603Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]ADRBK2
Spermophilus_tridecemlineatusone2one ENSSTOG00000001094Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Myotis_lucifugusone2one ENSMLUG00000008609Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000006729Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Echinops_telfairione2one ENSETEG00000005436Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Monodelphis_domesticaone2one ENSMODG00000010516Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Dipodomys_ordiione2one ENSDORG00000000748Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) [Source:UniProtKB/Swiss-Prot;Acc:Q3UYH7][hgnc]
Mus_musculusone2one ENSMUSG00000042249Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) [Source:UniProtKB/Swiss-Prot;Acc:Q3UYH7][hgnc]Adrbk2
Gallus_gallusone2one ENSGALG00000005518Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]ADRBK2
Takifugu_rubripesone2one ENSTRUG00000018612Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Danio_rerioone2one ENSDARG00000013007Novel protein similar to human adrenergic receptor kinase (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q801U1][hgnc]LOC569403
Tetraodon_nigroviridisone2one ENSTNIG00000013583Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Oryzias_latipesone2one ENSORLG00000001133Beta-adrenergic receptor kinase 2 (EC 2.7.11.15) (Beta-ARK-2) (G-protein-coupled receptor kinase 3) [Source:UniProtKB/Swiss-Prot;Acc:P35626][hgnc]
Anopheles_gambiaeone2many AGAP012026[hgnc]AgaP_ENSANGG00000006518
Aedes_aegyptione2many AAEL006868beta-adrenergic receptor kinase[hgnc]
Caenorhabditis_elegansone2many W02B3.2grk-2 encodes a serine/threonine protein kinase that is most closely related to G protein-coupled receptor (GPCR) kinases. in C. elegans, grk-2 activity is required in chemosensory neurons for normal calcium influx during chemosensation, but is not required for GPCR downregulation. in regulating chemosensation, GRK-2 likely acts upstream of the ODR-3/G alpha protein, as overexpression of ODR-3 can rescue abnormal avoidance behavior in grk-2 mutants. GRK-2 is broadly expressed in the adult nervous system, with expression beginning as early as the 20-30-cell stage of embryonic development and continuing into adulthood. [Source: WormBase][hgnc]grk-2
Drosophila_melanogasterone2many FBgn0004833[hgnc]Gprk1
Ciona_savignyione2many ENSCSAVG00000001890[hgnc]
Ciona_intestinalismany2many ENSCING00000016524[hgnc]
Ciona_intestinalismany2many ENSCING00000001450[hgnc]