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Summary sheet information for Effector 'EBP50/NHERF 1-Homo sapiens'
Name EBP50/NHERF 1-Homo sapiens
Description RecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Short=NHERF-1;AltName: Full=Ezrin-radixin-moesin-binding phosphoprotein 50; Short=EBP50;AltName: Full=Regulatory cofactor of Na(+)/H(+) exchanger;AltName: Full=Sodium-hydrogen exchanger regulatory factor 1;AltName: Full=Solute carrier family 9 isoform A3 regulatory factor 1
Class
Family Ezrin-radixin-moesin-binding phosphoproteins
Sub_family Ezrin-radixin-moesin-binding phosphoproteins
type EBP50/NHERF 1
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 17
Gene Start: 70256363
Gene End: 70277084
Ensembl Contig View
Ensembl Genes:
ENSG00000109062
EMBL:
EMBL ID  Description
AF015926  Homo sapiens ezrin-radixin-moesin binding phosphoprotein-50 mRNA, complete cds.
AF036241  Homo sapiens Na+/H+ exchange regulatory co-factor (NHERF) mRNA, complete cds.
AK312498  Homo sapiens cDNA, FLJ92860, highly similar to Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 (SLC9A3R1), mRNA.
BC001443  Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1, mRNA (cDNA clone MGC:1482 IMAGE:3138881), complete cds.
BC003361  Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1, mRNA (cDNA clone MGC:5270 IMAGE:2900516), complete cds.
BC011777  Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1, mRNA (cDNA clone MGC:19770 IMAGE:3640162), complete cds.
BC049220  Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1, mRNA (cDNA clone IMAGE:5496466), partial cds.
BC053350  Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1, mRNA (cDNA clone MGC:61480 IMAGE:5218414), complete cds.

EntrezGene:
ID  Description
SLC9A3R1  solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1
RefSeq DNA:
ID  Description
NM_004252  Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 (SLC9A3R1), mRNA.

UniGene:
ID  Description
Proteins
Ensembl Proteins:
ENSP00000262613
Entrez Proteins:
AAC04572.1; AAC52084.1; AAH01443.1; AAH03361.1; AAH11777.1; AAH49220.1; AAH53350.1; BAG35400.1
RefSeq Proteins:
ID  Description
NP_004243  sodium/hydrogen exchanger regulatory factor 1 [Homo sapiens].

UniProt:
ID  Description
B2R6A3  SubName: Full=cDNA, FLJ92860, highly similar to Homo sapiens solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 (SLC9A3R1), mRNA;
O14745  RecName: Full=Ezrin-radixin-moesin-binding phosphoprotein 50; Short=EBP50; AltName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF; AltName: Full=NHERF-1; AltName: Full=Regulatory cofactor of Na(+)/H(+) exchanger; AltName: Full=Sodium-hydrogen exchanger regulatory factor 1; AltName: Full=Solute carrier family 9 isoform A3 regulatory factor 1;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     EBP50/NHERF 1-Homo sapiens    

InterPro:
ID  Name
IPR017300  NaH_exchngr_reg_CF_NHE-RF
IPR015098  EBP50_C-term
IPR001478  PDZ/DHR/GLGF
Pfam:
ID  Description
PDZ  PDZ domain (Also known as DHR or GLGF)
EBP50_C-term  EBP50, C-terminal

Structure
PDB:
ID
1G9O
1GQ4
1GQ5
1I92
1SGH
2D10
2JXO
2OZF
HSSP:
ID  Description
1d5g  HYDROLASE
1g9o  SIGNALING PROTEIN
1gm1  HYDROLASE
1gq4  SIGNALING PROTEIN
1gq5  SIGNALING PROTEIN
1i92  SIGNALING PROTEIN
1iu0  NEUROPEPTIDE
1iu2  NEUROPEPTIDE
1kef  PROTEIN BINDING
1mfg  SIGNALING PROTEIN
1mfl  SIGNALING PROTEIN
1n7t  SIGNALING PROTEIN
1ozi  HYDROLASE
1pdr  SIGNAL TRANSDUCTION
1q3o  PEPTIDE BINDING PROTEIN
1q3p  PEPTIDE BINDING PROTEIN
1q7x  HYDROLASE
1qlc  PEPTIDE RECOGNITION
1rgr  STRUCTURAL PROTEIN/DE NOVO PROTEIN
1uez  PROTEIN BINDING
1uit  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
1ujd  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
1um1  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
1um7  PROTEIN BINDING
1v5l  STRUCTURAL PROTEIN
1vj6  HYDROLASE/SIGNALING PROTEIN
1wfv  SIGNALING PROTEIN
1wha  SIGNALING PROTEIN
1wi2  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
1wjl  PROTEIN BINDING
1x5q  CELL ADHESION, CELL CYCLE
1x5r  SIGNALING PROTEIN
2awu  MEMBRANE PROTEIN
2aww  MEMBRANE PROTEIN
2awx  MEMBRANE PROTEIN
2byg  SIGNAL TRANSDUCTION
2d10  CELL ADHESION
2d90  PROTEIN BINDING
2dkr  PROTEIN TRANSPORT
2edz  SIGNALING PROTEIN
2eeg  METAL BINDING PROTEIN
2eei  METAL BINDING PROTEIN
2eej  METAL BINDING PROTEIN
2egk  PROTEIN BINDING
2egn  PROTEIN BINDING
2ego  PROTEIN BINDING
2ehr  STRUCTURAL PROTEIN
2eno  ENDOCYTOSIS
2f5y  SIGNALING PROTEIN
2fcf  STRUCTURAL PROTEIN
2fe5  STRUCTURAL PROTEIN
2fne  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
2g2l  MEMBRANE PROTEIN
2h3l  CELL ADHESION
2he4  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
2i0i  PEPTIDE BINDING PROTEIN
2i0l  PEPTIDE BINDING PROTEIN
2iwq  SIGNALING PROTEIN
2jik  MEMBRANE PROTEIN
2jin  MEMBRANE PROTEIN
2joa  PROTEIN BINDING
2jxo  PROTEIN BINDING
2ocs  STRUCTURAL PROTEIN
2ogp  SIGNALING PROTEIN
2opg  STRUCTURAL PROTEIN
2oqs  PEPTIDE-BINDING PROTEIN
2ozf  PROTEIN BINDING
2pkt  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
2pnt  STRUCTURAL GENOMICS, UNKNOWN FUNCTION
2qbw  UNKNOWN FUNCTION
2r4h  TRANSFERASE
2v1w  STRUCTURAL PROTEIN
2v90  PROTEIN-BINDING
2vph  HYDROLASE
2vz5  PROTEIN BINDING
2w4f  STRUCTURAL PROTEIN
2yuy  SIGNALING PROTEIN
3bpu  TRANSFERASE
3diw  SIGNALING PROTEIN/CELL ADHESION
3dj1  SIGNALING PROTEIN
3dj3  SIGNALING PROTEIN
3pdz  HYDROLASE
PSSH:
ID  Description
O14745  UNKNOWN
Diseases
OMIM:
OMIM ID  Name  Alt Name
604990  SOLUTE CARRIER FAMILY 9, ISOFORM A3, REGULATORY FACTOR 1; SLC9A3R1   SODIUM/HYDROGEN EXCHANGER REGULATORY FACTOR 1; NHERF1 ERM-BINDING PHOSPHOPROTEIN, 50-KD; EBP50
Gene Ontology
GO:
GO ID  Description
GO:0005515  protein binding
GO:0006461  protein complex assembly
GO:0012505  endomembrane system
GO:0015629  actin cytoskeleton
GO:0016020  membrane
GO:0016055  Wnt receptor signaling pathway
GO:0016324  apical plasma membrane
GO:0030643  cellular phosphate ion homeostasis
GO:0031698  beta-2 adrenergic receptor binding
GO:0032415  regulation of sodium:hydrogen antiporter activity
GO:0042995  cell projection
GO:0045177  apical part of cell
Pathway
KEGG:
KEGG PATHWAY ID  Name
Panther:
ID  Description
Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000109062 Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745] Pan_troglodytesone2one ENSPTRG00000009616Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]SLC9A3R1
Pongo_pygmaeusone2one ENSPPYG00000008603Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Macaca_mulattaone2one ENSMMUG00000005737Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Myotis_lucifugusone2one ENSMLUG00000003257Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Tursiops_truncatusone2one ENSTTRG00000002603Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000001380Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Canis_familiarisone2one ENSCAFG00000004599Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]SLC9A3R1
Spermophilus_tridecemlineatusone2one ENSSTOG00000009583Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Tupaia_belangerione2one ENSTBEG00000003383Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Ochotona_princepsone2one ENSOPRG00000001457Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Cavia_porcellusone2one ENSCPOG00000000796Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000001575Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Dipodomys_ordiione2one ENSDORG00000005312Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:P70441][hgnc]
Procavia_capensisone2one ENSPCAG00000013968Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Loxodonta_africanaone2one ENSLAFG00000007518Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Bos_taurusone2one ENSBTAG00000011382Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform 3 regulatory f [Source:UniProtKB/Swiss-Prot;Acc:Q3SZK8][hgnc]SLC9A3R1
Rattus_norvegicusone2one ENSRNOG00000003232Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) (Sodium-hydrogen exchanger regulatory factor 1) (Solute carrier family 9 isoform A3 regulatory [Source:UniProtKB/Swiss-Prot;Acc:Q9JJ19][hgnc]Slc9a3r1
Otolemur_garnettiione2one ENSOGAG00000012306Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Vicugna_pacosone2one ENSVPAG00000010339Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Mus_musculusone2one ENSMUSG00000020733Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:P70441][hgnc]Slc9a3r1
Dasypus_novemcinctusone2one ENSDNOG00000011571Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Equus_caballusone2one ENSECAG00000014372Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Monodelphis_domesticaone2many ENSMODG00000006858[hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000012584Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Gallus_gallusone2one ENSGALG00000007650solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1 [Source:RefSeq_peptide;Acc:NP_001006424][hgnc]SLC9A3R1
Monodelphis_domesticaone2many ENSMODG00000015415[hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000011587Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Oryzias_latipesone2one ENSORLG00000012182Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000013210Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Xenopus_tropicalisone2one ENSXETG00000006840Solute carrier family 9 (Sodium/hydrogen exchanger), isoform 3 regulator 1. [Source:UniProtKB/TrEMBL;Acc:Q6DIL7][hgnc]
Danio_rerioone2one ENSDARG00000000068solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 1 [Source:RefSeq_peptide;Acc:NP_997872][hgnc]LOC795892
Takifugu_rubripesone2many ENSTRUG00000000690Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000015228Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000002951Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Takifugu_rubripesone2many ENSTRUG00000007970Ezrin-radixin-moesin-binding phosphoprotein 50 (EBP50) (Na(+)/H(+) exchange regulatory cofactor NHE-RF) (NHERF-1) (Regulatory cofactor of Na(+)/H(+) exchanger) [Source:UniProtKB/Swiss-Prot;Acc:O14745][hgnc]
Ciona_intestinalisone2many ENSCING00000002098[hgnc]
Ciona_savignyione2many ENSCSAVG00000011570[hgnc]