Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Summary sheet information for Effector 'TPR repeat protein 1-Homo sapiens'

Name

TPR repeat protein 1-Homo sapiens

Description

RecName: Full=Tetratricopeptide repeat protein 1; Short=TPR repeat protein 1

Class

Family

TPR repeat proteins

Sub_family

TPR repeat proteins

type

TPR repeat protein 1

Protein features link

Protein Information from Dasty2 DAS Client

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level

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Genes

Gene Location:

Chromosome	: 5
Gene Start	: 159368758
Gene End	: 159425128
Ensembl Contig View

Ensembl Genes:

ENSG00000113312

EMBL:

EMBL ID		Description
AK222641		Homo sapiens mRNA for tetratricopeptide repeat domain 1 variant, clone: CBL04274.
AK222984		Homo sapiens mRNA for tetratricopeptide repeat domain 1 variant, clone: HSI05523.
AK315262		Homo sapiens cDNA, FLJ96271, Homo sapiens tetratricopeptide repeat domain 1 (TTC1), mRNA.
BC000942		Homo sapiens tetratricopeptide repeat domain 1, mRNA (cDNA clone MGC:5385 IMAGE:3446109), complete cds.
CH471062		Homo sapiens 211000035832302 genomic scaffold, whole genome shotgun sequence.
U46570		Human tetratricopeptide repeat protein (tpr1) mRNA, complete cds.

EntrezGene:

ID		Description
TTC1		tetratricopeptide repeat domain 1

RefSeq DNA:

ID		Description
NM_003314		Homo sapiens tetratricopeptide repeat domain 1 (TTC1), mRNA.

UniGene:

Description

Proteins

Ensembl Proteins:

ENSP00000231238

Entrez Proteins:

AAB36871.1; AAH00942.1; BAD96361.1; BAD96704.1; BAG37679.1; EAW61570.1

RefSeq Proteins:

ID		Description
NP_003305		tetratricopeptide repeat domain 1 [Homo sapiens].

UniProt:

ID		Description
B2RCT2		SubName: Full=cDNA, FLJ96271, Homo sapiens tetratricopeptide repeat domain 1 (TTC1), mRNA (Tetratricopeptide repeat domain 1, isoform CRA_a);
Q53GE7		SubName: Full=Tetratricopeptide repeat domain 1 variant; Flags: Fragment;
Q53HD9		SubName: Full=Tetratricopeptide repeat domain 1 variant; Flags: Fragment;
Q99614		RecName: Full=Tetratricopeptide repeat protein 1; Short=TPR repeat protein 1;

Domains

SMART:

- Hyperlink to SMART;

- Hyperlink to ENSEMBL

TPR repeat protein 1-Homo sapiens

InterPro:

ID		Name
IPR013026		TPR_region
IPR001440		TPR-1
IPR011990		TPR-like_helical

Pfam:

ID		Description
TPR_1		Tetratricopeptide repeat

Structure

PDB:

HSSP:

ID		Description
2bug		HYDROLASE
2vyi		CHAPERONE

PSSH:

ID		Description
Q53GE7		UNKNOWN
Q53HD9		UNKNOWN
Q99614		UNKNOWN

Diseases

OMIM:

OMIM ID		Name		Alt Name
601963		TETRATRICOPEPTIDE REPEAT DOMAIN 1; TTC1		TETRATRICOPEPTIDE REPEAT-CONTAINING GENE 1; TPR1

Gene Ontology

GO:

GO ID		Description
GO:0005515		protein binding
GO:0006457		protein folding
GO:0051082		unfolded protein binding

Pathway

KEGG:

KEGG PATHWAY ID

Name

Panther:

Description

Chemicals

DrugBank:

Name

Synonyms

HMDB:

Name

Synonyms

Orthology

Orthology Relations:

Gene	Gene Description	Organism	Orthology type	Orthologs	Orthologs Description
ENSG00000113312	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614]	Pan_troglodytes	one2one	ENSPTRG00000017484	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]TTC1
		Pongo_pygmaeus	one2one	ENSPPYG00000016002	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Macaca_mulatta	one2one	ENSMMUG00000011471	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Microcebus_murinus	one2one	ENSMICG00000003241	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Tarsius_syrichta	one2one	ENSTSYG00000013670	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Pteropus_vampyrus	one2one	ENSPVAG00000011887	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Equus_caballus	one2one	ENSECAG00000006769	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]LOC100059774
		Oryctolagus_cuniculus	one2one	ENSOCUG00000005724	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Myotis_lucifugus	one2one	ENSMLUG00000003057	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Tursiops_truncatus	one2one	ENSTTRG00000012525	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Vicugna_pacos	one2one	ENSVPAG00000012031	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Dasypus_novemcinctus	one2one	ENSDNOG00000010399	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Loxodonta_africana	one2one	ENSLAFG00000016176	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Canis_familiaris	one2one	ENSCAFG00000017279	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]TTC1
		Procavia_capensis	one2one	ENSPCAG00000008266	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Otolemur_garnettii	one2one	ENSOGAG00000016342	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Cavia_porcellus	one2one	ENSCPOG00000004128	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Bos_taurus	one2one	ENSBTAG00000010321	Tetratricopeptide repeat protein 1 (TPR repeat protein 1). [Source:UniProtKB/Swiss-Prot;Acc:Q3ZBR5][hgnc]TTC1
		Tupaia_belangeri	one2one	ENSTBEG00000004641	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Mus_musculus	one2one	ENSMUSG00000041278	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q91Z38][hgnc]Ttc1
		Ochotona_princeps	one2one	ENSOPRG00000008796	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Rattus_norvegicus	one2one	ENSRNOG00000003980	tetratricopeptide repeat domain 1 [Source:RefSeq_peptide;Acc:NP_001005529][hgnc]Ttc1
		Echinops_telfairi	one2one	ENSETEG00000019397	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Dipodomys_ordii	one2one	ENSDORG00000000621	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q91Z38][hgnc]
		Monodelphis_domestica	one2one	ENSMODG00000008015	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Ornithorhynchus_anatinus	one2one	ENSOANG00000012333	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]100074701
		Sorex_araneus	one2one	ENSSARG00000002569	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Gallus_gallus	one2one	ENSGALG00000001429	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]TTC1
		Xenopus_tropicalis	one2one	ENSXETG00000005715	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Gasterosteus_aculeatus	one2one	ENSGACG00000020915	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Danio_rerio	one2one	ENSDARG00000044567	hypothetical protein LOC492510 [Source:RefSeq_peptide;Acc:NP_001007383][hgnc]LOC792141
		Oryzias_latipes	one2one	ENSORLG00000012795	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Takifugu_rubripes	one2one	ENSTRUG00000000528	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Tetraodon_nigroviridis	one2one	ENSTNIG00000007663	Tetratricopeptide repeat protein 1 (TPR repeat protein 1) [Source:UniProtKB/Swiss-Prot;Acc:Q99614][hgnc]
		Drosophila_melanogaster	one2one	FBgn0038428	[hgnc]CG14894
		Ciona_savignyi	one2one	ENSCSAVG00000001632	[hgnc]
		Ciona_intestinalis	one2one	ENSCING00000007127	[hgnc]
		Aedes_aegypti	one2one	AAEL009703	conserved hypothetical protein[hgnc]
		Anopheles_gambiae	one2one	AGAP003336	[hgnc]AgaP_ENSANGG00000011969