Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Summary sheet information for GPCR 'HISTAMINE RECEPTORS_H2_Homo sapiens'

Name

HISTAMINE RECEPTORS_H2_Homo sapiens

Description

RecName: Full=Histamine H2 receptor; Short=H2R;AltName: Full=Gastric receptor I

Class

CLASS A

Family

HISTAMINE RECEPTORS

Sub_family

type

Protein features link

Protein Information from Dasty2 DAS Client

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level

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Genes

Gene Location:

Chromosome	: 5
Gene Start	: 175017637
Gene End	: 175045851
Ensembl Contig View

Ensembl Genes:

ENSG00000113749

EMBL:

EMBL ID		Description
AB023486		Homo sapiens gene for histamine H2 receptor, promoter region and complete cds.
AB041384		Homo sapiens gene for histamine H2 receptor, complete cds.
AY136744		Homo sapiens histamine receptor H2 (HRH2) mRNA, complete cds.
BC054510		Homo sapiens histamine receptor H2, mRNA (cDNA clone MGC:60198 IMAGE:6146988), complete cds.
D49783		Homo sapiens gene for histamine H2 receptor, complete cds.
M64799		Human histamine H2 receptor gene, complete cds.
X98133		H.sapiens gene encoding histamine H2 receptor

EntrezGene:

ID		Description
HRH2		histamine receptor H2

RefSeq DNA:

ID		Description
NM_022304		Homo sapiens histamine receptor H2 (HRH2), transcript variant 2, mRNA.

UniGene:

ID		Description
Hs.247885		Histamine receptor H2 (HRH2), transcript variant 1, mRNA

Proteins

Ensembl Proteins:

ENSP00000231683; ENSP00000377350; ENSP00000366506

Entrez Proteins:

AAA58647.1; AAH54510.1; AAN01270.1; BAA08618.1; BAA84279.1; BAA94469.1; CAA66832.1

RefSeq Proteins:

ID		Description
NP_071640		histamine receptor H2 isoform 2 [Homo sapiens].

UniProt:

ID		Description
Q7Z5R9		SubName: Full=HRH2 protein;
P25021		RecName: Full=Histamine H2 receptor; Short=H2R; AltName: Full=Gastric receptor I;

Domains

SMART:

- Hyperlink to SMART;

- Hyperlink to ENSEMBL

InterPro:

ID		Name
IPR000276		GPCR_Rhodpsn
IPR000503		Histamine_H2_recept
IPR017452		GPCR_Rhodpsn_supfam

Pfam:

ID		Description
7tm_1		7 transmembrane receptor (rhodopsin family)

Structure

PDB:

HSSP:

ID		Description
2r4r		SIGNALING PROTEIN
2r4s		SIGNALING PROTEIN
2rh1		MEMBRANE PROTEIN / HYDROLASE
2vt4		RECEPTOR
3d4s		MEMBRANE PROTEIN
3eml		MEMBRANE PROTEIN, RECEPTOR

PSSH:

ID		Description
Q7Z5R9		UNKNOWN
P25021		UNKNOWN

Diseases

OMIM:

OMIM ID		Name		Alt Name
142703		HISTAMINE RECEPTOR H2; HRH2		UNKNOWN

Gene Ontology

GO:

GO ID		Description
GO:0001584		rhodopsin-like receptor activity
GO:0004872		receptor activity
GO:0004935		adrenoceptor activity
GO:0004952		dopamine receptor activity
GO:0004969		histamine receptor activity
GO:0004981		muscarinic acetylcholine receptor activity
GO:0004983		neuropeptide Y receptor activity
GO:0004984		olfactory receptor activity
GO:0005886		plasma membrane
GO:0005887		integral to plasma membrane
GO:0006955		immune response
GO:0007165		signal transduction
GO:0007186		G-protein coupled receptor protein signaling pathway
GO:0007187		G-protein signaling, coupled to cyclic nucleotide second messenger
GO:0008188		neuropeptide receptor activity
GO:0016020		membrane
GO:0016021		integral to membrane

Pathway

KEGG:

KEGG PATHWAY ID		Name
hsa04020		Calcium signaling pathway
hsa04080		Neuroactive ligand-receptor interaction

Panther:

ID		Description
P00026		Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P04386		Histamine H2 receptor mediated signaling pathway

Chemicals

DrugBank:

ID	Name	Synonyms
DB00501	Cimetidine	Cimetidine A/AB; Cimetidine Hcl
DB00863	Ranitidine	Ranitidine Base; Ranitidine HCL; Ranitidine hydrochloride; Rantidine HCL
DB01142	Doxepin	Doxepin Hcl; Doxepin, Hydrochloride; Doxepina [INN-Spanish]; Doxepine; Doxepinum [INN-Latin]
DB00272	Betazole	Ametazole; Betazol [INN-Spanish]; Betazolo [DCIT]; Betazolum [INN-Latin]
DB00751	Epinastine	Epinastina [Spanish]; Epinastinum [Latin]; epinastine
DB00667	Histamine Phosphate
DB00927	Famotidine	Famotidina [Spanish]; Famotidinum [Latin]
DB00585	Nizatidine

HMDB:

Name

Synonyms

Other GPCR resources

Links to other GPCR resources

GPCRDB | GPCR-OKB | GLIDA

Orthology

Orthology Relations:

Gene	Gene Description	Organism	Orthology type	Orthologs	Orthologs Description
ENSG00000113749	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021]	Pan_troglodytes	one2one	ENSPTRG00000017551	Histamine H2 receptor (H2R) (Gastric receptor I). [Source:UniProtKB/Swiss-Prot;Acc:P60021][hgnc]HRH2
		Pongo_pygmaeus	one2one	ENSPPYG00000016150	Histamine H2 receptor (H2R) (Gastric receptor I). [Source:UniProtKB/Swiss-Prot;Acc:P61752][hgnc]
		Macaca_mulatta	one2one	ENSMMUG00000014245	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Microcebus_murinus	one2one	ENSMICG00000003318	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Canis_familiaris	one2one	ENSCAFG00000016718	Histamine H2 receptor (H2R) (Gastric receptor I). [Source:UniProtKB/Swiss-Prot;Acc:P17124][hgnc]HRH2
		Cavia_porcellus	one2one	ENSCPOG00000003473	Histamine H2 receptor (H2R) (Gastric receptor I). [Source:UniProtKB/Swiss-Prot;Acc:P47747][hgnc]
		Tursiops_truncatus	one2one	ENSTTRG00000000456	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Felis_catus	one2one	ENSFCAG00000015411	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Spermophilus_tridecemlineatus	one2one	ENSSTOG00000007422	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Procavia_capensis	one2one	ENSPCAG00000007528	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Vicugna_pacos	one2one	ENSVPAG00000009965	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Ochotona_princeps	one2one	ENSOPRG00000001147	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Rattus_norvegicus	one2one	ENSRNOG00000018260	Histamine H2 receptor (H2R) (Gastric receptor I). [Source:UniProtKB/Swiss-Prot;Acc:P25102][hgnc]Hrh2
		Myotis_lucifugus	one2one	ENSMLUG00000007517	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Loxodonta_africana	one2one	ENSLAFG00000004764	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Equus_caballus	one2one	ENSECAG00000016581	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Mus_musculus	one2one	ENSMUSG00000034987	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P97292][hgnc]Hrh2
		Pteropus_vampyrus	one2one	ENSPVAG00000014807	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Monodelphis_domestica	one2one	ENSMODG00000005373	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Ornithorhynchus_anatinus	one2one	ENSOANG00000009335	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Gallus_gallus	one2one	ENSGALG00000024171	Histamine H2 receptor (Fragment). [Source:UniProtKB/TrEMBL;Acc:A2ICM8][hgnc]HRH2
		Gasterosteus_aculeatus	one2many	ENSGACG00000017883	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Tetraodon_nigroviridis	one2many	ENSTNIG00000013110	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Oryzias_latipes	one2many	ENSORLG00000003959	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Gasterosteus_aculeatus	one2many	ENSGACG00000020317	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Takifugu_rubripes	one2many	ENSTRUG00000010410	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Danio_rerio	one2one	ENSDARG00000057479	[hgnc]LOC100005590
		Tetraodon_nigroviridis	one2many	ENSTNIG00000010771	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Takifugu_rubripes	one2many	ENSTRUG00000007773	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Oryzias_latipes	one2many	ENSORLG00000010128	Histamine H2 receptor (H2R) (Gastric receptor I) [Source:UniProtKB/Swiss-Prot;Acc:P25021][hgnc]
		Anopheles_gambiae	one2many	AGAP004613	putative dopamine receptor 1 [Source:Anopheles_symbol;Acc:GPRDOP1][hgnc]GPRDOP1