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Summary sheet information for Effector 'Rac-Homo sapiens-2'
Name Rac-Homo sapiens-2
Description RecName: Full=Ras-related C3 botulinum toxin substrate 2;AltName: Full=p21-Rac2;AltName: Full=Small G protein;AltName: Full=GX;Flags: Precursor
Class
Family Small GTP-binding proteins
Sub_family Rho small GTPases
type Rac
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 22
Gene Start: 35951258
Gene End: 35970434
Ensembl Contig View
Ensembl Genes:
ENSG00000128340
EMBL:
EMBL ID  Description
AF498965  Homo sapiens small GTP binding protein RAC2 (RAC2) mRNA, complete cds.
BC001485  Homo sapiens ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2), mRNA (cDNA clone MGC:1383 IMAGE:3509104), complete cds.
BT006919  Homo sapiens ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) mRNA, complete cds.
CH471095  Homo sapiens 211000035831980 genomic scaffold, whole genome shotgun sequence.
CR456555  Homo sapiens RAC2 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.RAC2)
M29871  Human ras-related C3 botulinum toxin substrate (rac) mRNA, complete cds.
M64595  Human small G protein (Gx) mRNA, 3' end.
Z82188  Human DNA sequence from clone RP1-151B14 on chromosome 22 Contains, the 5' end of the IL2RB gene for interleukin 2 receptor, beta, a novel gene, the C1QTNF6 gene for C1q and tumor necrosis factor related protein 6, the SSTR3 gene for somatostatin receptor 3, the RAC2 gene for ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2), a ribosomal protein L39 (RPL39) pseudogene and three CpG islands.

EntrezGene:
ID  Description
RAC2  ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
RefSeq DNA:
ID  Description
NM_002872  Homo sapiens ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) (RAC2), mRNA.

UniGene:
ID  Description
Hs.517601  CDNA FLJ39605 fis, clone SKNSH2005981, weakly similar to RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2
Hs.627034  Transcribed locus

Proteins
Ensembl Proteins:
ENSP00000385666; ENSP00000385270; ENSP00000385590; ENSP00000249071
Entrez Proteins:
AAA35941.1; AAA36538.1; AAH01485.1; AAM21112.1; AAP35565.1; CAB45265.1; CAG30441.1; CAQ09480.1; CAQ09481.1; CAQ09482.1; CAQ09483.1; EAW60151.1; EAW60152.1
RefSeq Proteins:
ID  Description
NP_002863  ras-related C3 botulinum toxin substrate 2 [Homo sapiens].

UniProt:
ID  Description
B1AH77  SubName: Full=Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2);
B1AH78  SubName: Full=Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2); Flags: Fragment;
B1AH79  SubName: Full=Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2) (Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2), isoform CRA_d);
B1AH80  SubName: Full=Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2) (Ras-related C3 botulinum toxin substrate 2 (Rho family, small GTP binding protein Rac2), isoform CRA_c);
P15153  RecName: Full=Ras-related C3 botulinum toxin substrate 2; AltName: Full=p21-Rac2; AltName: Full=Small G protein; AltName: Full=GX; Flags: Precursor;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Rac-Homo sapiens-2    

InterPro:
ID  Name
IPR001806  Ras_trnsfrmng
IPR013753  Ras
IPR003578  GTPase_Rho
IPR005225  Small_GTP_bd
Pfam:
ID  Description
Ras  Ras family

Structure
PDB:
ID
1DS6
2W2T
2W2V
2W2X
HSSP:
ID  Description
1a2b  ONCOGENE PROTEIN
1a4r  HYDROLASE
1aje  G-PROTEIN
1am4  COMPLEX (GTPASE-ACTIVATING/GTP-BINDING)
1an0  GTPASE
1cc0  SIGNALING PROTEIN
1cee  STRUCTURAL PROTEIN REGULATION
1cf4  TRANSFERASE
1cxz  SIGNALING PROTEIN
1doa  CELL CYCLE
1dpf  GENE REGULATION/SIGNALING PROTEIN
1ds6  SIGNALING PROTEIN
1e0a  SIGNALLING PROTEIN
1e96  SIGNALLING COMPLEX
1ees  STRUCTURAL PROTEIN
1foe  SIGNALING PROTEIN, IMMUNE SYSTEM/SIGNALI
1ftn  PROTO-ONCOGENE
1g4u  SIGNALING PROTEIN
1grn  GENE REGULATION
1gwn  GTPASE
1gzs  COMPLEX (TOXIN/CELL CYCLE PROTEIN)
1he1  SIGNALLING COMPLEX
1hh4  SINGAL PROTEIN INHIBITOR COMPLEX
1i4d  SIGNALING PROTEIN
1i4l  SIGNALING PROTEIN
1i4t  SIGNALING PROTEIN
1ki1  SIGNALING PROTEIN
1kmq  SIGNALING PROTEIN
1kz7  SIGNALING PROTEIN
1kzg  SIGNALING PROTEIN
1lb1  SIGNALING PROTEIN
1m7b  SIGNALING PROTEIN
1mh1  GTP-BINDING
1nf3  SIGNALING PROTEIN
1ow3  GENE REGULATION/SIGNALING PROTEIN
1ryf  HYDROLASE
1ryh  HYDROLASE
1s1c  SIGNALING PROTEIN
1tx4  COMPLEX(GTPASE ACTIVATN/PROTO-ONCOGENE)
1x86  SIGNALING PROTEIN/MEMBRANE PROTEIN
1xcg  SIGNALING PROTEIN ACTIVATOR/SIGNALING PR
1z2c  SIGNALING PROTEIN
2ase  SIGNALING PROTEIN
2atx  HYDROLASE
2c2h  SIGNALING PROTEIN
2cls  NUCLEOTIDE BINDING PROTEIN
2dfk  CELL CYCLE
2fju  SIGNALING PROTEIN,APOPTOSIS/HYDROLASE
2fv8  SIGNALING PROTEIN
2g0n  SIGNALING PROTEIN
2gcn  SIGNALING PROTEIN
2gco  SIGNALING PROTEIN
2gcp  SIGNALING PROTEIN
2h7v  SIGNALING PROTEIN
2ic5  SIGNALING PROTEIN
2j0v  NUCLEOTIDE-BINDING PROTEIN
2j1l  HYDROLASE
2ngr  HYDROLASE
2nty  SIGNALING PROTEIN
2nz8  SIGNALING PROTEIN,CELL CYCLE
2odb  PROTEIN BINDING
2ov2  PROTEIN BINDING/TRANSFERASE
2p2l  UNKNOWN FUNCTION
2q3h  STRUCTURAL GENOMICS
2qme  SIGNALING PROTEIN/TRANSFERASE
2qrz  CELL CYCLE
2rex  SIGNALING PROTEIN/LIPOPROTEIN
2rgn  SIGNALING PROTEIN COMPLEX
2rmk  MEMBRANE PROTEIN/TRANSFERASE
2v55  TRANSFERASE
2vrw  SIGNALING PROTEIN
3bji  SIGNALING PROTEIN
3bwd  PLANT PROTEIN
3c5c  SIGNALING PROTEIN
3eg5  SIGNALING PROTEIN
PSSH:
ID  Description
P15153  UNKNOWN
Diseases
OMIM:
OMIM ID  Name  Alt Name
602049  RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 2; RAC2   RHO FAMILY, SMALL GTP-BINDING PROTEIN RAC2
Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0003924  GTPase activity
GO:0005515  protein binding
GO:0005525  GTP binding
GO:0005622  intracellular
GO:0005624  membrane fraction
GO:0005635  nuclear envelope
GO:0005737  cytoplasm
GO:0006813  potassium ion transport
GO:0006886  intracellular protein transport
GO:0006913  nucleocytoplasmic transport
GO:0006935  chemotaxis
GO:0007165  signal transduction
GO:0007264  small GTPase mediated signal transduction
GO:0008284  positive regulation of cell proliferation
GO:0008324  cation transmembrane transporter activity
GO:0010310  regulation of hydrogen peroxide metabolic process
GO:0015031  protein transport
GO:0030031  cell projection assembly
GO:0030036  actin cytoskeleton organization
GO:0060263  regulation of respiratory burst
Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04520  Adherens junction
hsa04360  Axon guidance
hsa04662  B cell receptor signaling pathway
hsa04062  Chemokine signaling pathway
hsa05210  Colorectal cancer
hsa04664  Fc epsilon RI signaling pathway
hsa04666  Fc gamma R-mediated phagocytosis
hsa04510  Focal adhesion
hsa04670  Leukocyte transendothelial migration
hsa04010  MAPK signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa05212  Pancreatic cancer
hsa05200  Pathways in cancer
hsa04810  Regulation of actin cytoskeleton
hsa04370  VEGF signaling pathway
hsa05416  Viral myocarditis
hsa04310  Wnt signaling pathway

Panther:
ID  Description
P05918  p38 MAPK pathway
P00008  Axon guidance mediated by Slit/Robo
P00010  B cell activation
P00053  T cell activation
P00031  Inflammation mediated by chemokine and cytokine signaling pathway
P00007  Axon guidance mediated by semaphorins
P04393  Ras Pathway
P00018  EGF receptor signaling pathway
P00034  Integrin signalling pathway
P00021  FGF signaling pathway
P00009  Axon guidance mediated by netrin
P00016  Cytoskeletal regulation by Rho GTPase
P00029  Huntington disease
Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000128340 Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153] Drosophila_melanogastermany2many FBgn0014011[hgnc]Rac2
Ciona_intestinalismany2many ENSCING00000002330Rac2 protein [Source:RefSeq_peptide;Acc:NP_001027787][hgnc]448954
Pongo_pygmaeusone2one ENSPPYG00000011791Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Macaca_mulattaone2one ENSMMUG00000018854Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000002281Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Bos_taurusone2one ENSBTAG00000011043Ras-related C3 botulinum toxin substrate 2 precursor (p21-Rac2). [Source:UniProtKB/Swiss-Prot;Acc:Q9TU25][hgnc]RAC2
Cavia_porcellusone2one ENSCPOG00000021900Ras-related C3 botulinum toxin substrate 2 precursor (p21-Rac2). [Source:UniProtKB/Swiss-Prot;Acc:O88931][hgnc]
Pan_troglodytesone2one ENSPTRG00000014331Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]RAC2
Oryctolagus_cuniculusone2one ENSOCUG00000016115Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000009509Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Microcebus_murinusone2one ENSMICG00000017775Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Tursiops_truncatusone2one ENSTTRG00000001099Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Canis_familiarisone2one ENSCAFG00000001508Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]RAC2
Equus_caballusone2one ENSECAG00000022570Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]LOC100054701
Myotis_lucifugusone2one ENSMLUG00000012668Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Rattus_norvegicusone2one ENSRNOG00000007350RAS-related C3 botulinum substrate 2 [Source:RefSeq_peptide;Acc:NP_001008385][hgnc]Rac2
Felis_catusone2one ENSFCAG00000013750Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000014015Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Mus_musculusone2one ENSMUSG00000033220Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (EN-7 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q05144][hgnc]Rac2
Otolemur_garnettiione2one ENSOGAG00000004138Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Ochotona_princepsone2one ENSOPRG00000014255Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Procavia_capensisone2one ENSPCAG00000002347Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Dipodomys_ordiione2one ENSDORG00000009206Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (EN-7 protein) [Source:UniProtKB/Swiss-Prot;Acc:Q05144][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000013618Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]100092844
Loxodonta_africanaone2one ENSLAFG00000013012Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Monodelphis_domesticaone2one ENSMODG00000000635Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Gallus_gallusone2one ENSGALG00000012456Hypothetical protein. [Source:UniProtKB/TrEMBL;Acc:Q5F337][hgnc]RAC2
Gasterosteus_aculeatusone2one ENSGACG00000001673Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Xenopus_tropicalisone2one ENSXETG00000004629Hypothetical LOC496738. [Source:UniProtKB/TrEMBL;Acc:Q5M8J2][hgnc]
Oryzias_latipesapprent_one2one ENSORLG00000008763Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Danio_rerioone2one ENSDARG00000038010ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) [Source:RefSeq_peptide;Acc:NP_001002061][hgnc]rac2
Takifugu_rubripesone2one ENSTRUG00000012912Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Drosophila_melanogastermany2many FBgn0010333[hgnc]Rac1
Tetraodon_nigroviridisone2one ENSTNIG00000018821Ras-related C3 botulinum toxin substrate 2 Precursor (p21-Rac2) (Small G protein) (GX) [Source:UniProtKB/Swiss-Prot;Acc:P15153][hgnc]
Aedes_aegyptione2many AAEL009732rac GTPase[hgnc]
Anopheles_gambiaeone2many AGAP005445[hgnc]AgaP_ENSANGG00000011739
Caenorhabditis_elegansmany2many C09G12.8ced-10 encodes a GTPase orthologous to human RAC1 (OMIM:602048) that is required for phagocytosis during programmed cell death and for migration of the distal tip cells of the somatic gonad. CED-10 functions in the engulfing cell during apoptosis, and is activated by a complex of CED-2(CrkII) and CED-5(DOCK180) to promote formation of the polarized cell extensions associated with cell corpse engulfment. [Source: WormBase][hgnc]ced-10
Ciona_intestinalismany2many ENSCING00000002350Rac1 protein [Source:RefSeq_peptide;Acc:NP_001027692][hgnc]445702
Caenorhabditis_elegansmany2many K03D3.10rac-2 encodes a small Rho family GTPase that, along with CED-10 and MIG-2, is one of three C. elegans Rac-related proteins. genetic studies indicate that rac-2 functions redundantly with mig-2 and ced-10 to regulate CAN and PDE axon pathfinding and CAN cell migration. in addition, rac-2 functions slightly redundant with mig-2 during distal tip cell movement and slightly redundant with ced-10 during cell-corpse phagocytosis. as unc-73 mutations enhance rac-2 defects in axon pathfinding and CAN cell migration, UNC-73/Trio is a likely candidate to act upstream of RAC-2 and positively regulate its GTPase activity in vivo. further, as UNC-115 activity is required to mediate the morphogenetic effects of constitutively active RAC-2(G12V), UNC-115, an actin-binding protein, is likely to be a downstream effector of RAC-2. GFP::RAC-2 reporters expressed in neurons and neuroblasts reveal localization at cell margins and the nerve ring, the latter suggesting that GFP::RAC-2 associates with the axonal plasma membrane. [Source: WormBase][hgnc]rac-2
Ciona_intestinalismany2many ENSCING00000002345Rac5 protein [Source:RefSeq_peptide;Acc:NP_001027789][hgnc]448958
Ciona_intestinalismany2many ENSCING00000002339Rac3b protein (EC 3.6.1.47) (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q7YT76][hgnc]
Ciona_intestinalismany2many ENSCING00000002335Rac4 protein [Source:RefSeq_peptide;Acc:NP_001027963][hgnc]448957