Human-gpDB    A database of human GPCRs, G-proteins, Effectors and their interactions

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	Summary sheet information for Effector 'SHC transforming protein 2-Homo sapiens'
Name	SHC transforming protein 2-Homo sapiens
Description	RecName: Full=SHC-transforming protein 2;AltName: Full=Src homology 2 domain-containing-transforming protein C2; Short=SH2 domain protein C2;AltName: Full=Protein Sck
Class
Family	SHC transforming proteins
Sub_family	SHC transforming proteins
type	SHC transforming protein 2
Protein features link	Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction	Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes	Gene Location: Chromosome : 19 Gene Start : 367593 Gene End : 411903 Ensembl Contig View Ensembl Genes: ENSG00000129946 EMBL: EMBL ID    Description AB001451    Homo sapiens mRNA for Sck, partial cds. AC006124    Homo sapiens chromosome 19, cosmid R34739, complete sequence. AC008988    Homo sapiens chromosome 19 clone LLNLF-215A5, complete sequence. AC138433    Homo sapiens chromosome 19 clone XXfos-85899E4, complete sequence. AL360254    Homo sapiens mRNA full length insert cDNA clone EUROIMAGE 979979. EntrezGene: ID    Description SHC2    SHC (Src homology 2 domain containing) transforming protein 2 RefSeq DNA: ID    Description NM_012435    Homo sapiens SHC (Src homology 2 domain containing) transforming protein 2 (SHC2), mRNA. UniGene: ID    Description Hs.30965    SHC (Src homology 2 domain containing) transforming protein 2 (SHC2), mRNA
Proteins	Ensembl Proteins: ENSP00000264554 Entrez Proteins: BAA25798.1; CAB96175.1 RefSeq Proteins: ID    Description NP_036567    SHC (Src homology 2 domain containing) transforming protein 2 [Homo sapiens]. UniProt: ID    Description P98077    RecName: Full=SHC-transforming protein 2; AltName: Full=Src homology 2 domain-containing-transforming protein C2; Short=SH2 domain protein C2; AltName: Full=Protein Sck;
Domains	SMART: - Hyperlink to SMART; - Hyperlink to ENSEMBL       SHC transforming protein 2-Homo sapiens     InterPro: ID    Name Pfam: ID    Description
Structure	PDB: ID HSSP: ID    Description 1a07    COMPLEX (TRANSFERASE/PEPTIDE) 1a08    COMPLEX (TRANSFERASE/PEPTIDE) 1a09    COMPLEX (TRANSFERASE/PEPTIDE) 1a1a    COMPLEX (TRANSFERASE/PEPTIDE) 1a1b    COMPLEX (TRANSFERASE/PEPTIDE) 1a1c    COMPLEX (TRANSFERASE/PEPTIDE) 1a1e    COMPLEX (TRANSFERASE/PEPTIDE) 1aot    COMPLEX (PROTO-ONCOGENE/EARLY PROTEIN) 1aou    COMPLEX (PROTO-ONCOGENE/EARLY PROTEIN) 1bkl    V-SRC SH2 DOMAIN 1bkm    TRANSFORMING PROTEIN 1bm2    HORMONE/GROWTH FACTOR 1bmb    HORMONE/GROWTH FACTOR 1cj1    SIGNALING PROTEIN 1csy    COMPLEX (PHOSPHOTRANSFERASE/PEPTIDE) 1csz    COMPLEX (PHOSPHOTRANSFERASE/PEPTIDE) 1d1z    GENE REGULATION 1d4t    SIGNALING PROTEIN 1d4w    SIGNALING PROTEIN 1f1w    TRANSFERASE 1f2f    TRANSFERASE 1fhs    SH2 DOMAIN 1fu5    PEPTIDE BINDING PROTEIN 1fu6    PROTEIN BINDING 1fyr    HORMONE/GROWTH FACTOR 1ghu    SRC HOMOLOGY 2 DOMAIN 1hcs    COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) 1hct    COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) 1is0    TRANSFERASE 1ju5    PROTEIN BINDING/TRANSFERASE 1jwo    TRANSFERASE 1jyq    SIGNALING PROTEIN 1jyr    SIGNALING PROTEIN 1jyu    SIGNALING PROTEIN 1ka6    IMMUNE SYSTEM 1ka7    IMMUNE SYSTEM 1kc2    TRANSFERASE 1lui    TRANSFERASE 1luk    TRANSFERASE 1lum    TRANSFERASE 1lun    TRANSFERASE 1m27    SIGNALING PROTEIN, TRANSFERASE 1mil    TRANSFORMING PROTEIN 1mw4    HORMONE/GROWTH FACTOR/TRANSFERASE 1n3h    SIGNALING PROTEIN 1nrv    SIGNALING PROTEIN 1nzl    TRANSFERASE 1nzv    TRANSFERASE 1o41    SIGNALING PROTEIN 1o42    SIGNALING PROTEIN 1o43    SIGNALING PROTEIN 1o44    SIGNALING PROTEIN 1o45    SIGNALING PROTEIN 1o46    SIGNALING PROTEIN 1o47    SIGNALING PROTEIN 1o48    SIGNALING PROTEIN 1o49    SIGNALING PROTEIN 1o4a    SIGNALING PROTEIN 1o4b    SIGNALING PROTEIN 1o4c    SIGNALING PROTEIN 1o4d    SIGNALING PROTEIN 1o4e    SIGNALING PROTEIN 1o4f    SIGNALING PROTEIN 1o4g    SIGNALING PROTEIN 1o4h    SIGNALING PROTEIN 1o4i    SIGNALING PROTEIN 1o4j    SIGNALING PROTEIN 1o4k    SIGNALING PROTEIN 1o4l    SIGNALING PROTEIN 1o4m    SIGNALING PROTEIN 1o4n    SIGNALING PROTEIN 1o4o    SIGNALING PROTEIN 1o4p    SIGNALING PROTEIN 1o4q    SIGNALING PROTEIN 1o4r    SIGNALING PROTEIN 1oo3    PROTEIN BINDING 1oo4    PROTEIN BINDING 1oy2    SIGNALING PROTEIN 1p13    TRANSFERASE 1qg1    HORMONE/GROWTH FACTOR 1rja    TRANSFERASE 1rpy    SIGNALING PROTEIN 1rqq    TRANSFERASE/SIGNALING PROTEIN 1sha    PHOSPHOTRANSFERASE 1shb    PHOSPHOTRANSFERASE 1shc    COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) 1skj    TYROSINE-PROTEIN KINASE 1spr    TRANSFERASE(PHOSPHOTRANSFERASE) 1sps    TRANSFERASE(PHOSPHOTRANSFERASE) 1tce    COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) 1tze    COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) 1wqu    TRANSFERASE 1x0n    PEPTIDE BINDING PROTEIN 1zfp    COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE) 2aoa    TRANSFERASE 2aob    TRANSFERASE 2aug    SIGNALING PROTEIN 2c9w    TRANSCRIPTION REGULATION 2dcr    TRANSFERASE 2dvj    SIGNALING PROTEIN 2dx0    HYDROLASE 2ecd    SIGNALING PROTEIN 2eo3    SIGNALING PROTEIN 2etz    TRANSFERASE 2eu0    TRANSFERASE 2eyv    SIGNALING PROTEIN 2eyy    SIGNALING PROTEIN 2eyz    SIGNALING PROTEIN 2ge9    TRANSFERASE 2h46    HORMONE/GROWTH FACTOR 2h5k    HORMONE/GROWTH FACTOR 2hdv    SIGNALING PROTEIN 2hdx    SIGNALING PROTEIN 2huw    HORMONE/GROWTH FACTOR 2iug    TRANSFERASE 2iuh    TRANSFERASE 2iui    TRANSFERASE 2jyq    TRANSFERASE 2pna    SIGNALLING PROTEIN 2pnb    SIGNALLING PROTEIN 2qms    SIGNALING PROTEIN 3c7i    SPLICING PSSH: ID    Description P98077    UNKNOWN
Diseases	OMIM: OMIM ID    Name    Alt Name 605217    SHC TRANSFORMING PROTEIN 2; SHC2    SHC PROTEIN B; SHCB SHC-LIKE PROTEIN SCK; SCK SHC ADAPTOR HOMOLOG, NEURONAL
Gene Ontology	GO: GO ID    Description GO:0005515    protein binding GO:0005575    cellular_component GO:0007242    intracellular signaling cascade GO:0007265    Ras protein signal transduction
Pathway	KEGG: KEGG PATHWAY ID    Name hsa04062    Chemokine signaling pathway hsa05220    Chronic myeloid leukemia hsa04012    ErbB signaling pathway hsa04510    Focal adhesion hsa05214    Glioma hsa04910    Insulin signaling pathway hsa04650    Natural killer cell mediated cytotoxicity hsa04722    Neurotrophin signaling pathway hsa04370    VEGF signaling pathway Panther: ID    Description P00047    PDGF signaling pathway P00018    EGF receptor signaling pathway P00056    VEGF signaling pathway P00005    Angiogenesis
Chemicals	DrugBank: ID    Name    Synonyms HMDB: ID    Name    Synonyms
Orthology	Orthology Relations: Gene Gene Description Organism Orthology type Orthologs Orthologs Description ENSG00000129946 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077] Pongo_pygmaeus one2one ENSPPYG00000009272 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Pan_troglodytes one2one ENSPTRG00000010145 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc]LOC749831 Microcebus_murinus one2one ENSMICG00000004066 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Otolemur_garnettii one2one ENSOGAG00000004603 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Pteropus_vampyrus one2one ENSPVAG00000000050 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Macaca_mulatta one2one ENSMMUG00000000485 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Myotis_lucifugus one2one ENSMLUG00000016048 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Felis_catus one2one ENSFCAG00000015438 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Tursiops_truncatus one2one ENSTTRG00000016131 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Bos_taurus one2one ENSBTAG00000016072 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc]SHC2 Cavia_porcellus one2one ENSCPOG00000026631 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Procavia_capensis one2one ENSPCAG00000009058 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Dipodomys_ordii one2one ENSDORG00000001524 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) (Protein Sli) [Source:UniProtKB/Swiss-Prot;Acc:Q8BMC3][hgnc] Sorex_araneus one2one ENSSARG00000002741 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Ochotona_princeps one2one ENSOPRG00000007295 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Rattus_norvegicus one2one ENSRNOG00000008030 src homology 2 domain-containing transforming protein C2 [Source:RefSeq_peptide;Acc:NP_001101535][hgnc]Shc2_predicted Mus_musculus one2one ENSMUSG00000020312 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) (Protein Sli) [Source:UniProtKB/Swiss-Prot;Acc:Q8BMC3][hgnc]Shc2 Canis_familiaris one2one ENSCAFG00000019724 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc]SHC2 Erinaceus_europaeus one2one ENSEEUG00000013016 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Equus_caballus one2one ENSECAG00000009683 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Ornithorhynchus_anatinus one2one ENSOANG00000006978 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc]100081397 Gallus_gallus one2one ENSGALG00000001289 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc]SHC2 Xenopus_tropicalis one2one ENSXETG00000006562 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Danio_rerio one2one ENSDARG00000062080 hypothetical protein LOC562011 [Source:RefSeq_peptide;Acc:NP_001038438][hgnc]si:dkey-94n12.3 Oryzias_latipes one2one ENSORLG00000016822 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Gasterosteus_aculeatus one2one ENSGACG00000011551 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Takifugu_rubripes one2one ENSTRUG00000009298 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Tetraodon_nigroviridis one2one ENSTNIG00000015451 SHC-transforming protein 2 (Src homology 2 domain-containing-transforming protein C2) (SH2 domain protein C2) (Protein Sck) [Source:UniProtKB/Swiss-Prot;Acc:P98077][hgnc] Ciona_intestinalis one2many ENSCING00000006400 [hgnc]