Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Summary sheet information for Effector 'Raf1 protein kinase-Homo sapiens'

Name

Raf1 protein kinase-Homo sapiens

Description

RecName: Full=RAF proto-oncogene serine/threonine-protein kinase; EC=2.7.11.1;AltName: Full=C-RAF; Short=cRaf;AltName: Full=Raf-1

Class

Family

Ser Thr protein kinases

Sub_family

RAF protein kinases

type

Raf1 protein kinase

Protein features link

Protein Information from Dasty2 DAS Client

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level

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Genes

Gene Location:

Chromosome	: 3
Gene Start	: 12600108
Gene End	: 12680678
Ensembl Contig View

Ensembl Genes:

ENSG00000132155

EMBL:

EMBL ID		Description
AK312248		Homo sapiens cDNA, FLJ92543, highly similar to Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1(RAF1), mRNA.
AY271661		Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene, complete cds.
BC018119		Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1, mRNA (cDNA clone MGC:9026 IMAGE:3904404), complete cds.
CH471055		Homo sapiens 211000035832932 genomic scaffold, whole genome shotgun sequence.
EU332868		Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene, complete cds.
L00206		Human c-raf-1 proto-oncogene, exon 3, clones lambda-(2,13).
L00207		Human c-raf-1 proto-oncogene, exon 4, clones lambda-(2,13).
L00208		Human c-raf-1 proto-oncogene, exon 5, clones lambda-(2,13).
L00209		Human c-raf-1 proto-oncogene, exon 6, clones lambda-(2,13).
L00210		Human c-raf-1 proto-oncogene, exon 7, clones lambda-(2,13).
L00211		Human c-raf-1 proto-oncogene, exon 8, clones lambda-(2,13).
L00212		Human c-raf-1 proto-oncogene (RAF1) gene, exons 9,10 and 11, clones lambda-(2,13).
L00213		Human c-raf-1 proto-oncogene, exon 2, clones lambda-(2,13).
M11376		Human c-raf-1 proto-oncogene, exon 1, clones lambda-(2,13).
X03484		Human mRNA for raf oncogene
X54851		H.sapiens C-raf-1 gene exon 7A

EntrezGene:

ID		Description
RAF1		v-raf-1 murine leukemia viral oncogene homolog 1

RefSeq DNA:

ID		Description
NM_002880		Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1), mRNA.

UniGene:

ID		Description
Hs.159130		Raf oncogene

Proteins

Ensembl Proteins:

ENSP00000251849

Entrez Proteins:

AAA60247.1; AAH18119.1; AAP03432.1; ABY87557.1; BAG35180.1; CAA27204.1; EAW64134.1

RefSeq Proteins:

ID		Description
NP_002871		v-raf-1 murine leukemia viral oncogene homolog 1 [Homo sapiens].

UniProt:

ID		Description
P04049-2		UNKNOWN
B2R5N3		UNKNOWN
P04049		RecName: Full=RAF proto-oncogene serine/threonine-protein kinase; EC=2.7.11.1; AltName: Full=C-RAF; Short=cRaf; AltName: Full=Raf-1;

Domains

SMART:

- Hyperlink to SMART;

- Hyperlink to ENSEMBL

Raf1 protein kinase-Homo sapiens

InterPro:

ID		Name
IPR017442		Se/Thr_pkinase-rel
IPR000719		Prot_kinase_core
IPR017441		Protein_kinase_ATP_bd_CS
IPR003116		Raf_like_ras_bd
IPR008271		Ser_thr_pkin_AS
IPR002219		DAG_PE_bd

Pfam:

ID		Description
Pkinase		Protein kinase domain
C1_1		Phorbol esters/diacylglycerol binding domain (C1 domain)
RBD		Raf-like Ras-binding domain

Structure

PDB:

HSSP:

ID		Description
1c1y		SIGNALING PROTEIN
1faq		SERINE/THREONINE PROTEIN KINASE
1far		SERINE/THREONINE PROTEIN KINASE
1gua		COMPLEX (GTP-BINDING/ATP-BINDING)
1ias		TRANSFERASE
1py5		TRANSFERASE
1rfa		SERINE/THREONINE-PROTEIN KINASE
1rrb		TRANSFERASE
1rw8		TRANSFERASE
1uwh		KINASE
1uwj		KINASE
1vjy		TRANSFERASE
1wxm		TRANSFERASE
2a19		PROTEIN SYNTHESIS/TRANSFERASE
2eva		TRANSFERASE/TRANSFERASE ACTIVATOR
2fb8		TRANSFERASE
3c4c		TRANSFERASE
3c4d		TRANSFERASE
3d4q		TRANSFERASE
3faa		TRANSFERASE

PSSH:

ID		Description
P04049		UNKNOWN
Q15278		UNKNOWN

Diseases

OMIM:

OMIM ID		Name		Alt Name
164760		V-RAF-1 MURINE LEUKEMIA VIRAL ONCOGENE HOMOLOG 1; RAF1		ONCOGENE RAF1 TRANSFORMING REPLICATION-DEFECTIVE MURINE RETROVIRUS 3611-MSV ONCOGENE MIL CRAF

Gene Ontology

GO:

GO ID		Description
GO:0000166		nucleotide binding
GO:0004672		protein kinase activity
GO:0004674		protein serine/threonine kinase activity
GO:0004713		protein tyrosine kinase activity
GO:0005057		receptor signaling protein activity
GO:0005515		protein binding
GO:0005524		ATP binding
GO:0005741		mitochondrial outer membrane
GO:0005829		cytosol
GO:0005886		plasma membrane
GO:0006468		protein amino acid phosphorylation
GO:0006915		apoptosis
GO:0007010		cytoskeleton organization
GO:0007165		signal transduction
GO:0007242		intracellular signaling cascade
GO:0007265		Ras protein signal transduction
GO:0008270		zinc ion binding
GO:0008283		cell proliferation
GO:0016740		transferase activity
GO:0019992		diacylglycerol binding
GO:0046872		metal ion binding
GO:0048011		nerve growth factor receptor signaling pathway

Pathway

KEGG:

KEGG PATHWAY ID		Name
hsa05221		Acute myeloid leukemia
hsa04662		B cell receptor signaling pathway
hsa05219		Bladder cancer
hsa04062		Chemokine signaling pathway
hsa05220		Chronic myeloid leukemia
hsa05210		Colorectal cancer
hsa05213		Endometrial cancer
hsa04012		ErbB signaling pathway
hsa04664		Fc epsilon RI signaling pathway
hsa04666		Fc gamma R-mediated phagocytosis
hsa04510		Focal adhesion
hsa04540		Gap junction
hsa05214		Glioma
hsa04912		GnRH signaling pathway
hsa04910		Insulin signaling pathway
hsa04730		Long-term depression
hsa04720		Long-term potentiation
hsa04010		MAPK signaling pathway
hsa04916		Melanogenesis
hsa05218		Melanoma
hsa04650		Natural killer cell mediated cytotoxicity
hsa04722		Neurotrophin signaling pathway
hsa05223		Non-small cell lung cancer
hsa05212		Pancreatic cancer
hsa05200		Pathways in cancer
hsa04914		Progesterone-mediated oocyte maturation
hsa05215		Prostate cancer
hsa04810		Regulation of actin cytoskeleton
hsa05211		Renal cell carcinoma
hsa04660		T cell receptor signaling pathway
hsa04370		VEGF signaling pathway
hsa04270		Vascular smooth muscle contraction

Panther:

ID		Description
P05911		Angiotensin II-stimulated signaling through G proteins and beta-arrestin
P00036		Interleukin signaling pathway
P00047		PDGF signaling pathway
P00019		Endothelin signaling pathway
P00010		B cell activation
P00053		T cell activation
P00031		Inflammation mediated by chemokine and cytokine signaling pathway
P04393		Ras Pathway
P00018		EGF receptor signaling pathway
P00032		Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
P00034		Integrin signalling pathway
P00056		VEGF signaling pathway
P00021		FGF signaling pathway
P00005		Angiogenesis

Chemicals

DrugBank:

ID		Name		Synonyms
DB00398		Sorafenib		Sorafenib tosylate; sorafenib

HMDB:

Name

Synonyms

Orthology

Orthology Relations:

Gene	Gene Description	Organism	Orthology type	Orthologs	Orthologs Description
ENSG00000132155	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049]	Pan_troglodytes	one2one	ENSPTRG00000014635	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]RAF1
		Pongo_pygmaeus	one2one	ENSPPYG00000013388	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf). [Source:UniProtKB/Swiss-Prot;Acc:Q5R5M7][hgnc]
		Macaca_mulatta	one2many	ENSMMUG00000007450	[hgnc]
		Microcebus_murinus	one2one	ENSMICG00000012172	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Macaca_mulatta	one2many	ENSMMUG00000009202	[hgnc]
		Tarsius_syrichta	one2one	ENSTSYG00000007438	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Pteropus_vampyrus	one2one	ENSPVAG00000005823	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Myotis_lucifugus	one2one	ENSMLUG00000017645	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Tupaia_belangeri	one2one	ENSTBEG00000012253	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Equus_caballus	one2many	ENSECAG00000011807	[hgnc]LOC100051110
		Loxodonta_africana	one2one	ENSLAFG00000011608	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Oryctolagus_cuniculus	one2one	ENSOCUG00000014175	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Felis_catus	one2one	ENSFCAG00000007975	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Procavia_capensis	one2one	ENSPCAG00000016080	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Equus_caballus	one2many	ENSECAG00000005116	[hgnc]LOC100050968
		Canis_familiaris	one2one	ENSCAFG00000004951	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]RAF1
		Vicugna_pacos	one2one	ENSVPAG00000011066	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Dasypus_novemcinctus	one2one	ENSDNOG00000009252	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Bos_taurus	one2one	ENSBTAG00000004514	PREDICTED: Bos taurus hypothetical LOC521196 (LOC521196), mRNA. [Source:RefSeq_dna;Acc:XR_027356][hgnc]RAF1
		Echinops_telfairi	one2one	ENSETEG00000003974	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Mus_musculus	one2one	ENSMUSG00000000441	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:Q99N57][hgnc]Raf1
		Rattus_norvegicus	one2one	ENSRNOG00000010153	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (Raf- 1) (C-RAF) (cRaf). [Source:UniProtKB/Swiss-Prot;Acc:P11345][hgnc]Raf1
		Ochotona_princeps	one2one	ENSOPRG00000003522	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Cavia_porcellus	one2one	ENSCPOG00000001210	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Dipodomys_ordii	one2one	ENSDORG00000015622	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:Q99N57][hgnc]
		Erinaceus_europaeus	one2one	ENSEEUG00000011360	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Sorex_araneus	one2one	ENSSARG00000007569	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Monodelphis_domestica	one2one	ENSMODG00000006307	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Gallus_gallus	one2one	ENSGALG00000004998	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (RAF- 1) (C-RAF) (MIL proto-oncogene serine/threonine-protein kinase) (C- MIL). [Source:UniProtKB/Swiss-Prot;Acc:P05625][hgnc]RAF1
		Takifugu_rubripes	one2one	ENSTRUG00000006611	serine/threonine protein kinase RAF1 [Source:RefSeq_peptide;Acc:NP_001033078][hgnc]raf1
		Tetraodon_nigroviridis	one2one	ENSTNIG00000012621	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Xenopus_tropicalis	one2one	ENSXETG00000020163	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Oryzias_latipes	one2one	ENSORLG00000011471	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]
		Danio_rerio	one2one	ENSDARG00000059406	similar to protein kinase raf 1 (LOC557109), misc RNA [Source:RefSeq_dna;Acc:XR_029877][hgnc]
		Gasterosteus_aculeatus	one2one	ENSGACG00000000060	RAF proto-oncogene serine/threonine-protein kinase (EC 2.7.11.1) (C-RAF) (cRaf) (Raf-1) [Source:UniProtKB/Swiss-Prot;Acc:P04049][hgnc]