Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Summary sheet information for Effector 'Rap1GAPII-Homo sapiens-2'

Name

Rap1GAPII-Homo sapiens-2

Description

RecName: Full=Rap1 GTPase-activating protein 2; Short=Rap1GAP2;AltName: Full=GTPase-activating Rap/Ran-GAP domain-like protein 4

Class

Family

GTPase activating proteins

Sub_family

Rap-specific GAPs

type

Rap1GAPII

Protein features link

Protein Information from Dasty2 DAS Client

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level

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Genes

Gene Location:

Chromosome	: 17
Gene Start	: 2646482
Gene End	: 2884500
Ensembl Contig View

Ensembl Genes:

ENSG00000132359

EMBL:

EMBL ID		Description
AB028962		Homo sapiens mRNA for KIAA1039 protein, partial cds.
AJ628446		Homo sapiens mRNA for Rap1 GTPase activating protein 2b (RAP1GA2 gene)
AJ628447		Homo sapiens mRNA for Rap1 GTPase activating protein 2a (RAP1GA2 gene)
AK124640		Homo sapiens cDNA FLJ42649 fis, clone BRACE3027326, moderately similar to RAP1 GTPase activating protein 1.
BC140870		Homo sapiens GTPase activating Rap/RanGAP domain-like 4, mRNA (cDNA clone MGC:176547 IMAGE:9021738), complete cds.
BC140871		Homo sapiens GTPase activating Rap/RanGAP domain-like 4, mRNA (cDNA clone MGC:176548 IMAGE:9021739), complete cds.
CR627427		Homo sapiens mRNA; cDNA DKFZp686O238 (from clone DKFZp686O238)

EntrezGene:

ID		Description
GARNL4		GTPase activating Rap/RanGAP domain-like 4

RefSeq DNA:

ID		Description
NM_001100398		Homo sapiens GTPase activating Rap/RanGAP domain-like 4 (GARNL4), transcript variant 2, mRNA.
NM_015085		Homo sapiens GTPase activating Rap/RanGAP domain-like 4 (GARNL4), transcript variant 1, mRNA.

UniGene:

ID		Description
Hs.499659		GTPase activating Rap/RanGAP domain-like 4, mRNA (cDNA clone MGC:176548 IMAGE:9021739)

Proteins

Ensembl Proteins:

ENSP00000254695

Entrez Proteins:

AAI40871.1; AAI40872.1; BAA82991.1; BAC85912.1; CAF31652.1; CAF31653.1; CAH10514.1

RefSeq Proteins:

ID		Description
NP_001093868		GTPase activating Rap/RanGAP domain-like 4 isoform 2 [Homo sapiens].
NP_055900		GTPase activating Rap/RanGAP domain-like 4 isoform 1 [Homo sapiens].

UniProt:

ID		Description
Q684P5-2		UNKNOWN
Q684P5-3		UNKNOWN
B2RTY5		UNKNOWN
Q684P5		RecName: Full=Rap1 GTPase-activating protein 2; Short=Rap1GAP2; AltName: Full=GTPase-activating Rap/Ran-GAP domain-like protein 4;

Domains

SMART:

- Hyperlink to SMART;

- Hyperlink to ENSEMBL

InterPro:

ID		Name
IPR000331		Rap_GAP

Pfam:

ID		Description
Rap_GAP		Rap/ran-GAP

Structure

PDB:

HSSP:

ID		Description
1srq		SIGNALING PROTEIN
3brw		GTP BINDING PROTEIN

PSSH:

Description

Diseases

OMIM:

OMIM ID

Name

Alt Name

Gene Ontology

GO:

GO ID		Description
GO:0005096		GTPase activator activity
GO:0005622		intracellular
GO:0005737		cytoplasm
GO:0051056		regulation of small GTPase mediated signal transduction

Pathway

KEGG:

KEGG PATHWAY ID

Name

Panther:

Description

Chemicals

DrugBank:

Name

Synonyms

HMDB:

Name

Synonyms

Orthology

Orthology Relations:

Gene	Gene Description	Organism	Orthology type	Orthologs	Orthologs Description
ENSG00000132359	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5]	Pan_troglodytes	one2one	ENSPTRG00000008553	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Pongo_pygmaeus	one2one	ENSPPYG00000007798	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Macaca_mulatta	one2one	ENSMMUG00000022989	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Tupaia_belangeri	one2one	ENSTBEG00000013283	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Microcebus_murinus	one2one	ENSMICG00000007259	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Otolemur_garnettii	one2one	ENSOGAG00000016436	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Tursiops_truncatus	one2one	ENSTTRG00000001194	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Pteropus_vampyrus	one2one	ENSPVAG00000011780	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Loxodonta_africana	one2one	ENSLAFG00000012620	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Spermophilus_tridecemlineatus	one2one	ENSSTOG00000014200	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Cavia_porcellus	one2one	ENSCPOG00000000079	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Oryctolagus_cuniculus	one2one	ENSOCUG00000000200	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Vicugna_pacos	one2one	ENSVPAG00000001877	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Dipodomys_ordii	one2one	ENSDORG00000008796	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q5SVL6][hgnc]
		Myotis_lucifugus	one2one	ENSMLUG00000011541	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Canis_familiaris	one2one	ENSCAFG00000019305	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]GARNL4
		Equus_caballus	one2one	ENSECAG00000020278	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]LOC100072524
		Ochotona_princeps	one2one	ENSOPRG00000002360	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Mus_musculus	one2one	ENSMUSG00000038807	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q5SVL6][hgnc]Garnl4
		Rattus_norvegicus	one2one	ENSRNOG00000002652	GTPase activating RANGAP domain-like 4 [Source:RefSeq_peptide;Acc:NP_001100489][hgnc]Garnl4_predicted
		Bos_taurus	one2one	ENSBTAG00000020000	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Felis_catus	one2one	ENSFCAG00000007849	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Dasypus_novemcinctus	one2one	ENSDNOG00000007971	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Procavia_capensis	one2one	ENSPCAG00000006506	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Erinaceus_europaeus	one2one	ENSEEUG00000006009	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Sorex_araneus	one2one	ENSSARG00000012591	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Monodelphis_domestica	one2one	ENSMODG00000010843	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Gallus_gallus	one2one	ENSGALG00000005868	GTPase activating Rap/RanGAP domain-like 4 [Source:RefSeq_peptide;Acc:NP_001026649][hgnc]RCJMB04_18p7
		Ornithorhynchus_anatinus	one2one	ENSOANG00000010097	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]100079986
		Xenopus_tropicalis	one2one	ENSXETG00000012970	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Danio_rerio	one2one	ENSDARG00000061551	GTPase activating Rap/RanGAP domain-like [Source:RefSeq_peptide;Acc:NP_001071023][hgnc]zgc:153898
		Gasterosteus_aculeatus	one2one	ENSGACG00000006227	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Oryzias_latipes	one2many	ENSORLG00000014038	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Oryzias_latipes	one2many	ENSORLG00000013672	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Takifugu_rubripes	one2one	ENSTRUG00000002741	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Tetraodon_nigroviridis	one2one	ENSTNIG00000004777	Rap1 GTPase-activating protein 2 (Rap1GAP2) (GTPase-activating Rap/Ran-GAP domain-like protein 4) [Source:UniProtKB/Swiss-Prot;Acc:Q684P5][hgnc]
		Ciona_savignyi	one2many	ENSCSAVG00000010331	[hgnc]
		Ciona_intestinalis	one2many	ENSCING00000001624	[hgnc]