Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Summary sheet information for Effector 'Adenylate cyclase 3-Homo sapiens'

Name

Adenylate cyclase 3-Homo sapiens

Description

"RecName: Full=Adenylate cyclase type 3; EC=4.6.1.1;AltName: Full=Adenylate cyclase type III; Short=AC-III;AltName: Full=ATP pyrophosphate-lyase 3;AltName: Full=Adenylyl cyclase 3; Short=AC3;AltName: Full=Adenylate cyclase, olfactive type;"

Class

Family

Cyclases

Sub_family

Adenylate cyclases

type

Adenylate cyclase 3

Protein features link

Protein Information from Dasty2 DAS Client

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level

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Genes

Gene Location:

Chromosome	: 2
Gene Start	: 24895545
Gene End	: 24995559
Ensembl Contig View

Ensembl Genes:

ENSG00000138031

EMBL:

EMBL ID		Description
AB011083		Homo sapiens mRNA for KIAA0511 protein, partial cds.
AC012073		Homo sapiens BAC clone RP11-443B20 from 2, complete sequence.
AF033861		Homo sapiens type III adenylyl cyclase (AC-III) mRNA, complete cds.
AK075424		Homo sapiens cDNA PSEC0115 fis, clone PLACE1000086, highly similar to ADENYLATE CYCLASE, OLFACTIVE TYPE (EC 4.6.1.1).
BC126235		Homo sapiens adenylate cyclase 3, mRNA (cDNA clone MGC:161513 IMAGE:8991951), complete cds.

EntrezGene:

ID		Description
ADCY3		adenylate cyclase 3

RefSeq DNA:

ID		Description
NM_004036		Homo sapiens adenylate cyclase 3 (ADCY3), mRNA.

UniGene:

ID		Description
Hs.467898		CDNA FLJ14953 fis, clone PLACE3000160
Hs.681728		Transcribed locus, strongly similar to NP_004027.2 adenylate cyclase 3 [Homo sapiens]

Proteins

Ensembl Proteins:

ENSP00000384484; ENSP00000260600

Entrez Proteins:

AAD13403.1; AAI26236.1; AAY14787.1; BAA25437.1; BAC11613.1

RefSeq Proteins:

ID		Description
NP_004027		adenylate cyclase 3 [Homo sapiens].

UniProt:

ID		Description
Q8NBM1		SubName: Full=cDNA PSEC0115 fis, clone PLACE1000086, highly similar to ADENYLATE CYCLASE, OLFACTIVE TYPE (EC 4.6.1.1);
O60266		RecName: Full=Adenylate cyclase type 3; EC=4.6.1.1; AltName: Full=Adenylate cyclase type III; Short=AC-III; AltName: Full=ATP pyrophosphate-lyase 3; AltName: Full=Adenylyl cyclase 3; Short=AC3; AltName: Full=Adenylate cyclase, olfactive type;

Domains

SMART:

- Hyperlink to SMART;

- Hyperlink to ENSEMBL

Adenylate cyclase 3-Homo sapiens

InterPro:

ID		Name
IPR001054		A/G_cyclase

Pfam:

ID		Description
Guanylate_cyc		Adenylate and Guanylate cyclase catalytic domain
Guanylate_cyc		Adenylate and Guanylate cyclase catalytic domain

Structure

PDB:

HSSP:

ID		Description
1ab8		LYASE
1azs		COMPLEX (LYASE/HYDROLASE)
1cjk		LYASE/LYASE/SIGNALING PROTEIN
1cjt		LYASE/LYASE/SIGNALING PROTEIN
1cju		LYASE/LYASE/SIGNALING PROTEIN
1cjv		LYASE/LYASE/SIGNALING PROTEIN
1cs4		LYASE/LYASE/SIGNALING PROTEIN
1cul		LYASE/LYASE/SIGNALING PROTEIN
1tl7		LYASE
1u0h		LYASE
1yk9		LYASE
2gvd		LYASE
2gvz		LYASE
3c14		LYASE/LYASE INHIBITOR
3c15		LYASE/LYASE INHIBITOR
3c16		LYASE/LYASE INHIBITOR
3et6		LYASE

PSSH:

ID		Description
Q8NBM1		UNKNOWN
O60266		UNKNOWN

Diseases

OMIM:

OMIM ID		Name		Alt Name
600291		ADENYLATE CYCLASE 3; ADCY3		ADENYLYL CYCLASE 3 KIAA0511

Gene Ontology

GO:

GO ID		Description
GO:0000287		magnesium ion binding
GO:0005515		protein binding
GO:0005516		calmodulin binding
GO:0005886		plasma membrane
GO:0005887		integral to plasma membrane
GO:0006171		cAMP biosynthetic process
GO:0007143		female meiosis
GO:0007242		intracellular signaling cascade
GO:0007608		sensory perception of smell
GO:0008294		calcium- and calmodulin-responsive adenylate cyclase activity
GO:0009190		cyclic nucleotide biosynthetic process
GO:0016849		phosphorus-oxygen lyase activity
GO:0045121		membrane raft
GO:0050896		response to stimulus

Pathway

KEGG:

KEGG PATHWAY ID		Name
hsa04020		Calcium signaling pathway
hsa04062		Chemokine signaling pathway
hsa05414		Dilated cardiomyopathy
hsa04540		Gap junction
hsa04912		GnRH signaling pathway
hsa04916		Melanogenesis
hsa04740		Olfactory transduction
hsa04114		Oocyte meiosis
hsa04914		Progesterone-mediated oocyte maturation
hsa00230		Purine metabolism
hsa04270		Vascular smooth muscle contraction
hsa04962		Vasopressin-regulated water reabsorption
hsa05110		Vibrio cholerae infection

Panther:

ID		Description
P00026		Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P00019		Endothelin signaling pathway

Chemicals

DrugBank:

Name

Synonyms

HMDB:

ID	Name	Synonyms
HMDB00538	Adenosine triphosphate	5'-(tetrahydrogen triphosphate) Adenosine; 5'-ATP; ATP; Adenosine 5'-triphosphate; Adenosine 5'-triphosphorate; Adenosine 5'-triphosphoric acid; Adenosine triphosphate; Adenosine triphosphic acid; Adenylpyrophosphorate; Adenylpyrophosphoric acid; Adephos; Adetol; Adynol; Atipi; Atriphos; Cardenosine; Fosfobion; Glucobasin; Myotriphos; Phosphobion; Striadyne; Triadenyl; Triphosphaden; Triphosphoric acid adenosine ester
HMDB00058	Cyclic AMP	Cyclic AMP; 3'5'-cyclic AMP; 6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide; Acrasin; Adenosine 3',5'-cyclic monophosphate; Adenosine 3',5'-cyclic phosphate; Adenosine 3',5'-cyclophosphate; Adenosine 3',5'-monophosphate; Adenosine 3,5'-cyclic monophosphorate; Adenosine 3,5'-cyclic monophosphoric acid; Adenosine cyclic monophosphate; Cyclic 3',5'-AMP; Cyclic 3',5'-adenylate; Cyclic 3',5'-adenylic acid; Cyclic adenosine 3',5'-phosphate; adenosine cyclic-monophosphate; adenosine-cyclic-phosphate; adenosine-cyclic-phosphoric-acid; cAMP
HMDB00250	Pyrophosphate	(4-)Diphosphoric acid ion; (P2O74-)Diphosphate; Diphosphate; Pyrometaphosphate; Pyrophosphate; Pyrophosphate tetraanion; Pyrophosphate(4-) ion; Pyrophosphic acid

Orthology

Orthology Relations:

Gene	Gene Description	Organism	Orthology type	Orthologs	Orthologs Description
ENSG00000138031	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266]	Pan_troglodytes	one2one	ENSPTRG00000011718	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]ADCY3
		Pongo_pygmaeus	one2one	ENSPPYG00000012595	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Macaca_mulatta	one2one	ENSMMUG00000009600	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Tarsius_syrichta	one2one	ENSTSYG00000010032	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Microcebus_murinus	one2one	ENSMICG00000001584	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Otolemur_garnettii	one2one	ENSOGAG00000000758	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Equus_caballus	one2one	ENSECAG00000008344	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]LOC100055961
		Bos_taurus	one2one	ENSBTAG00000018705	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]ADCY3
		Spermophilus_tridecemlineatus	one2one	ENSSTOG00000006049	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Dasypus_novemcinctus	one2one	ENSDNOG00000009972	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Pteropus_vampyrus	one2one	ENSPVAG00000017518	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Dipodomys_ordii	one2one	ENSDORG00000007778	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:Q8VHH7][hgnc]
		Procavia_capensis	one2one	ENSPCAG00000007573	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Loxodonta_africana	one2one	ENSLAFG00000014458	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Myotis_lucifugus	one2one	ENSMLUG00000014135	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Tursiops_truncatus	one2one	ENSTTRG00000015147	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Canis_familiaris	one2one	ENSCAFG00000004090	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]ADCY3
		Felis_catus	one2one	ENSFCAG00000003651	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Mus_musculus	one2one	ENSMUSG00000020654	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:Q8VHH7][hgnc]Adcy3
		Rattus_norvegicus	one2one	ENSRNOG00000003999	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC-III) (AC3) (Adenylate cyclase, olfactive type). [Source:UniProtKB/Swiss-Prot;Acc:P21932][hgnc]Adcy3
		Tupaia_belangeri	one2one	ENSTBEG00000007613	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Erinaceus_europaeus	one2one	ENSEEUG00000004393	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Cavia_porcellus	one2one	ENSCPOG00000005564	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Vicugna_pacos	one2one	ENSVPAG00000005559	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Oryctolagus_cuniculus	one2one	ENSOCUG00000015443	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Ochotona_princeps	one2one	ENSOPRG00000008617	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Echinops_telfairi	one2one	ENSETEG00000007357	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Monodelphis_domestica	one2one	ENSMODG00000015887	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Gallus_gallus	one2one	ENSGALG00000016608	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Takifugu_rubripes	one2many	ENSTRUG00000007837	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Tetraodon_nigroviridis	one2many	ENSTNIG00000011677	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Gasterosteus_aculeatus	one2many	ENSGACG00000014041	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Xenopus_tropicalis	one2one	ENSXETG00000021179	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Gasterosteus_aculeatus	one2many	ENSGACG00000013394	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Danio_rerio	one2one	ENSDARG00000017437	Novel protein similar to vertebrate adenylate cyclase 3 (ADCY3) (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q5SP66][hgnc]si:ch211-153j24.5
		Takifugu_rubripes	one2many	ENSTRUG00000015342	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Oryzias_latipes	one2one	ENSORLG00000016865	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]
		Tetraodon_nigroviridis	one2many	ENSTNIG00000006752	Adenylate cyclase type 3 (EC 4.6.1.1) (Adenylate cyclase type III) (AC-III) (ATP pyrophosphate-lyase 3) (Adenylyl cyclase 3) (AC3) (Adenylate cyclase, olfactive type) [Source:UniProtKB/Swiss-Prot;Acc:O60266][hgnc]