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Summary sheet information for Effector 'Voltage dependent N type calcium channel-Homo sapiens'
Name Voltage dependent N type calcium channel-Homo sapiens
Description "RecName: Full=Voltage-dependent N-type calcium channel subunit alpha-1B;AltName: Full=Voltage-gated calcium channel subunit alpha Cav2.2;AltName: Full=Calcium channel, L type, alpha-1 polypeptide isoform 5;AltName: Full=Brain calcium channel III; Short=BIII;"
Class
Family Ion channels
Sub_family Voltage dependent calcium channels
type Voltage dependent N type calcium channel
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 9
Gene Start: 139892062
Gene End: 140138897
Ensembl Contig View
Ensembl Genes:
ENSG00000148408
EMBL:
EMBL ID  Description
AB209467  Homo sapiens mRNA for calcium channel, voltage-dependent, L type, alpha 1B subunit variant protein.
AF233289  Homo sapiens calcium channel alpha12.2 subunit (CACNA1B) gene, exons 18 and 19.
AF237470  Homo sapiens calcium channel alpha12.2 subunit (CACNA1B) gene; exons 9, 10A and 10B; and partial cds, alternatively spliced.
AF238295  Homo sapiens calcium channel alpha12.2 subunit (CACNA1B) gene; exons 41, 42 and 43; and partial cds, alternatively spliced.
AF238296  Homo sapiens calcium channel alpha12.2 subunit (CACNA1B) gene, exon 22 and partial cds, alternatively spliced.
AF239237  Homo sapiens calcium channel alpha12.2 subunit (CACNA1B) gene, exons 20 and 21.
AF245659  Homo sapiens calcium channel alpha12.2 subunit (CACNA1B) gene, exons 32 and 33, and partial cds.
AF245660  Homo sapiens calcium channel alpha12.2 subunit (CACNA1B) gene; exons 27, 28, and 29; and partial cds, alternatively spliced.
AF247811  Homo sapiens calcium channel alpha12.2 subunit (CACNA1B) gene, exon 8.
AF302779  Homo sapiens calcium channel alpha12.2 subunit (CACNA1B) gene, exon 17.
AF302780  Homo sapiens calcium channel alpha12.2 subunit (CACNA1B) gene, exon 20 and partial cds, alternatively spliced.
AF302782  Homo sapiens calcium channel alpha12.2 subunit (CACNA1B) gene; exons 23, 24 and 25; and partial cds, alternatively spliced.
AL591424  Human DNA sequence from clone RP11-424E7 on chromosome 9 Contains the 3' end of the CACNA1B gene for alpha 1B subunit of L type voltage-dependent calcium channel, a pseudogene similar to part of interleukin 9 receptor (ILR9), a tubulin, beta polypeptide 4, member Q (TUBB4Q) pseudogene and five CpG islands.
AL772363  Human DNA sequence from clone RP11-974F22 on chromosome 9 Contains the 5' end of the CACNA1B gene for alpha 1B subunit of L type voltage-dependent calcium channel and two CpG islands.
M94172  Human N-type calcium channel alpha-1 subunit mRNA, complete cds.
M94173  Human N-type calcium channel alpha-1 subunit mRNA, complete cds.
U76666  Human N-type calcium channel alpha1B subunit gene, 5' upstream region and partial cds.

EntrezGene:
ID  Description
CACNA1B  calcium channel, voltage-dependent, N type, alpha 1B subunit
RefSeq DNA:
ID  Description
NM_000718  Homo sapiens calcium channel, voltage-dependent, N type, alpha 1B subunit (CACNA1B), mRNA.

UniGene:
ID  Description
Hs.495522  CDNA clone IMAGE:5265218

Proteins
Ensembl Proteins:
ENSP00000360416; ENSP00000360418; ENSP00000289992; ENSP00000277550; ENSP00000277551; ENSP00000360408; ENSP00000360414; ENSP00000360423; ENSP00000360406; ENSP00000277549
Entrez Proteins:
AAA51897.1; AAA51898.1; AAC51138.1; AAG13642.1; AAG13643.1; AAG13644.1; AAG13645.2; AAG13647.1; AAG13648.1; AAG13649.1; AAG13650.1; AAG14396.1; AAG14397.1; AAG14398.1; BAD92704.1; CAI17141.1; CAI17142.1; CAI17143.1; CAI17144.1; CAI40685.1; CAI40686.1; CAI40687.1; CAI40688.1; CAI40691.1
RefSeq Proteins:
ID  Description
NP_000709  calcium channel, voltage-dependent, N type, alpha 1B subunit [Homo sapiens].

UniProt:
ID  Description
Q00975-2  UNKNOWN
B1AQK4  SubName: Full=Calcium channel, voltage-dependent, N type, alpha 1B subunit;
B1AQK6  SubName: Full=Calcium channel, voltage-dependent, N type, alpha 1B subunit;
B1AQK7  SubName: Full=Calcium channel, voltage-dependent, N type, alpha 1B subunit;
Q59FJ3  SubName: Full=Calcium channel, voltage-dependent, L type, alpha 1B subunit variant; Flags: Fragment;
Q5JRE4  SubName: Full=Calcium channel, voltage-dependent, N type, alpha 1B subunit; Flags: Fragment;
Q9HAT3  SubName: Full=Calcium channel alpha12.2 subunit; Flags: Fragment;
Q9HAT4  SubName: Full=Calcium channel alpha12.2 subunit; Flags: Fragment;
Q9HAT5  SubName: Full=Calcium channel alpha12.2 subunit; Flags: Fragment;
Q9HAT6  SubName: Full=Calcium channel alpha12.2 subunit; Flags: Fragment;
Q9HBG2  SubName: Full=Calcium channel alpha12.2 subunit; Flags: Fragment;
Q9HBG3  SubName: Full=Calcium channel alpha12.2 subunit; Flags: Fragment;
Q9HBH2  SubName: Full=Calcium channel alpha12.2 subunit; Flags: Fragment;
Q9HBH3  SubName: Full=Calcium channel alpha12.2 subunit; Flags: Fragment;
Q9HBH4  SubName: Full=Calcium channel alpha12.2 subunit; Flags: Fragment;
Q9HBI3  SubName: Full=Calcium channel alpha12.2 subunit; Flags: Fragment;
Q9HBI4  SubName: Full=Calcium channel alpha12.2 subunit; Flags: Fragment;
Q00975  RecName: Full=Voltage-dependent N-type calcium channel subunit alpha-1B; AltName: Full=Voltage-gated calcium channel subunit alpha Cav2.2; AltName: Full=Calcium channel, L type, alpha-1 polypeptide isoform 5; AltName: Full=Brain calcium channel III; Short=BIII;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Voltage dependent N type calcium channel-Homo sapiens    

InterPro:
ID  Name
IPR005821  Ion_trans
IPR002048  EF_hand_Ca_bd
IPR005447  VDCC_N_a1su
IPR014873  VDCC_a1su_IQ
IPR002077  VDCCAlpha1
Pfam:
ID  Description
Ion_trans  Ion transport protein
Ion_trans  Ion transport protein
Ion_trans  Ion transport protein
Ca_chan_IQ  Voltage gated calcium channel IQ domain

Structure
PDB:
ID
HSSP:
ID  Description
1vyt  ION TRANSPORT/COMPLEX
3dve  MEMBRANE PROTEIN
3dvj  MEMBRANE PROTEIN
PSSH:
ID  Description
Q59FJ3  UNKNOWN
Q00975  UNKNOWN
Diseases
OMIM:
OMIM ID  Name  Alt Name
601012  CALCIUM CHANNEL, VOLTAGE-DEPENDENT, N TYPE, ALPHA-1B SUBUNIT; CACNA1B   CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 5; CACNL1A5
Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0001518  voltage-gated sodium channel complex
GO:0005216  ion channel activity
GO:0005244  voltage-gated ion channel activity
GO:0005245  voltage-gated calcium channel activity
GO:0005248  voltage-gated sodium channel activity
GO:0005509  calcium ion binding
GO:0005515  protein binding
GO:0005524  ATP binding
GO:0005886  plasma membrane
GO:0005891  voltage-gated calcium channel complex
GO:0006811  ion transport
GO:0006814  sodium ion transport
GO:0006816  calcium ion transport
GO:0007268  synaptic transmission
GO:0007269  neurotransmitter secretion
GO:0007626  locomotory behavior
GO:0008016  regulation of heart contraction
GO:0008022  protein C-terminus binding
GO:0008217  regulation of blood pressure
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0030425  dendrite
GO:0043025  cell soma
GO:0043198  dendritic shaft
GO:0043679  nerve terminal
Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa04010  MAPK signaling pathway
hsa04742  Taste transduction
hsa04930  Type II diabetes mellitus

Panther:
ID  Description
P00039  Metabotropic glutamate receptor group III pathway
P05730  Endogenous cannabinoid signaling
P05731  GABA-B receptor II signaling
P04394  Thyrotropin-releasing hormone receptor signaling pathway
P00037  Ionotropic glutamate receptor pathway
P00040  Metabotropic glutamate receptor group II pathway
P00027  Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Chemicals
DrugBank:
ID  Name  Synonyms
DB00996  Gabapentin  Gabapentin GR; Gabapentine [INN-French]; Gabapentino [INN-Spanish]; Gabapentino [Spanish]; Gabapentinum [INN-Latin]; Gabapetin; gabapentin
DB00381  Amlodipine  Amlodipine Benzenesulfonate; Amlodipine Besilate; Amlodipine Besylate; Amlodipine Free Base; Amlodipino [Spanish]; Amlodipinum [Latin]
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000148408 Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975] Pan_troglodytesone2one ENSPTRG00000021608Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]LOC748383
Pongo_pygmaeusone2one ENSPPYG00000019840Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Microcebus_murinusone2one ENSMICG00000016743Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Dipodomys_ordiione2one ENSDORG00000011586Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:O55017][hgnc]
Equus_caballusone2one ENSECAG00000011838Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Felis_catusone2one ENSFCAG00000001217Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Canis_familiarisone2one ENSCAFG00000019380Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000004575Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Mus_musculusone2one ENSMUSG00000004113Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:O55017][hgnc]Cacna1b
Rattus_norvegicusone2one ENSRNOG00000004560Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) (BIII). [Source:UniProtKB/Swiss-Prot;Acc:Q02294][hgnc]Cacna1b
Cavia_porcellusone2one ENSCPOG00000004438Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Otolemur_garnettiione2one ENSOGAG00000016377Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000012674Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Ochotona_princepsone2one ENSOPRG00000007181Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Bos_taurusone2one ENSBTAG00000007882Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000011912Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Procavia_capensisone2one ENSPCAG00000001683Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Tupaia_belangerione2one ENSTBEG00000010369Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Macaca_mulattaone2one ENSMMUG00000009187Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Tursiops_truncatusone2one ENSTTRG00000013845Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Monodelphis_domesticaone2one ENSMODG00000017101Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Gallus_gallusone2one ENSGALG00000008456Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage- gated calcium channel subunit alpha Cav2.2) (CHCACHA1B) (Fragment). [Source:UniProtKB/Swiss-Prot;Acc:O73706][hgnc]CACNA1B
Ornithorhynchus_anatinusone2one ENSOANG00000011856Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000018069Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Danio_rerioone2one ENSDARG00000021735Novel protein similar to vertebrate calcium channel, voltage- dependent, L type, alpha 1B subunit (CACNA1B). [Source:UniProtKB/TrEMBL;Acc:A2BHF3][hgnc]
Oryzias_latipesone2one ENSORLG00000013818Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Takifugu_rubripesone2one ENSTRUG00000006562Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000005212Voltage-dependent N-type calcium channel subunit alpha-1B (Voltage-gated calcium channel subunit alpha Cav2.2) (Calcium channel, L type, alpha-1 polypeptide isoform 5) (Brain calcium channel III) [Source:UniProtKB/Swiss-Prot;Acc:Q00975][hgnc]