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Summary sheet information for Effector 'Adenylate cyclase 8-Homo sapiens'
Name Adenylate cyclase 8-Homo sapiens
Description RecName: Full=Adenylate cyclase type 8; EC=4.6.1.1;AltName: Full=Adenylate cyclase type VIII;AltName: Full=ATP pyrophosphate-lyase 8;AltName: Full=Adenylyl cyclase 8;AltName: Full=Ca(2+)/calmodulin-activated adenylyl cyclase
Class
Family Cyclases
Sub_family Adenylate cyclases
type Adenylate cyclase 8
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 8
Gene Start: 131861736
Gene End: 132123854
Ensembl Contig View
Ensembl Genes:
ENSG00000155897
EMBL:
EMBL ID  Description
DQ104739  Homo sapiens brain adenylate cyclase 8 (ADCY8) mRNA, complete cds, alternatively spliced.
M83533  Homo sapiens adenylyl cyclase type V mRNA, partial cds.
Z35309  H.sapiens mRNA for adenylyl cyclase

EntrezGene:
ID  Description
ADCY8  adenylate cyclase 8 (brain)
LOC100134077  similar to adenylyl cyclase
RefSeq DNA:
ID  Description
NM_001115  Homo sapiens adenylate cyclase 8 (brain) (ADCY8), mRNA.
XM_001713841  PREDICTED: Homo sapiens similar to adenylyl cyclase (LOC100134077), mRNA.

UniGene:
ID  Description
Hs.591859  Adenylyl cyclase

Proteins
Ensembl Proteins:
ENSP00000367161; ENSP00000286355
Entrez Proteins:
AAA35523.2; AAZ13596.1; CAA84552.1
RefSeq Proteins:
ID  Description
NP_001106  adenylate cyclase 8 [Homo sapiens].
XP_001713893  PREDICTED: similar to adenylyl cyclase [Homo sapiens].

UniProt:
ID  Description
Q4F7X0  SubName: Full=Brain adenylate cyclase 8;
P40145  RecName: Full=Adenylate cyclase type 8; EC=4.6.1.1; AltName: Full=Adenylate cyclase type VIII; AltName: Full=ATP pyrophosphate-lyase 8; AltName: Full=Adenylyl cyclase 8; AltName: Full=Ca(2+)/calmodulin-activated adenylyl cyclase;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Adenylate cyclase 8-Homo sapiens    

InterPro:
ID  Name
IPR001054  A/G_cyclase
IPR000209  Pept_S8_S53
IPR009398  Aden_cycl_like
Pfam:
ID  Description
Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain
DUF1053  Domain of Unknown Function (DUF1053)

Structure
PDB:
ID
HSSP:
ID  Description
1ab8  LYASE
1azs  COMPLEX (LYASE/HYDROLASE)
1cjk  LYASE/LYASE/SIGNALING PROTEIN
1cjt  LYASE/LYASE/SIGNALING PROTEIN
1cju  LYASE/LYASE/SIGNALING PROTEIN
1cjv  LYASE/LYASE/SIGNALING PROTEIN
1cs4  LYASE/LYASE/SIGNALING PROTEIN
1cul  LYASE/LYASE/SIGNALING PROTEIN
1tl7  LYASE
1u0h  LYASE
1yk9  LYASE
2gvd  LYASE
2gvz  LYASE
3c14  LYASE/LYASE INHIBITOR
3c15  LYASE/LYASE INHIBITOR
3c16  LYASE/LYASE INHIBITOR
3et6  LYASE
PSSH:
ID  Description
Q4F7X0  UNKNOWN
P40145  UNKNOWN
Diseases
OMIM:
OMIM ID  Name  Alt Name
103070  ADENYLATE CYCLASE 8; ADCY8   ADCY8 ADENYLYL CYCLASE, BRAIN, TYPE I ADENYLATE CYCLASE 3, FORMERLY; ADCY3, FORMERLY
Gene Ontology
GO:
GO ID  Description
GO:0000287  magnesium ion binding
GO:0004016  adenylate cyclase activity
GO:0004289  subtilase activity
GO:0005624  membrane fraction
GO:0005886  plasma membrane
GO:0006171  cAMP biosynthetic process
GO:0006508  proteolysis
GO:0007242  intracellular signaling cascade
GO:0007611  learning or memory
GO:0007616  long-term memory
GO:0008294  calcium- and calmodulin-responsive adenylate cyclase activity
GO:0009190  cyclic nucleotide biosynthetic process
GO:0009755  hormone-mediated signaling
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0016849  phosphorus-oxygen lyase activity
Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa04062  Chemokine signaling pathway
hsa05414  Dilated cardiomyopathy
hsa04540  Gap junction
hsa04912  GnRH signaling pathway
hsa04720  Long-term potentiation
hsa04916  Melanogenesis
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa00230  Purine metabolism
hsa04742  Taste transduction
hsa04270  Vascular smooth muscle contraction

Panther:
ID  Description
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P05731  GABA-B receptor II signaling
P00019  Endothelin signaling pathway
Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
HMDB00538   Adenosine triphosphate   5'-(tetrahydrogen triphosphate) Adenosine; 5'-ATP; ATP; Adenosine 5'-triphosphate; Adenosine 5'-triphosphorate; Adenosine 5'-triphosphoric acid; Adenosine triphosphate; Adenosine triphosphic acid; Adenylpyrophosphorate; Adenylpyrophosphoric acid; Adephos; Adetol; Adynol; Atipi; Atriphos; Cardenosine; Fosfobion; Glucobasin; Myotriphos; Phosphobion; Striadyne; Triadenyl; Triphosphaden; Triphosphoric acid adenosine ester
HMDB00058   Cyclic AMP   Cyclic AMP; 3'5'-cyclic AMP; 6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide; Acrasin; Adenosine 3',5'-cyclic monophosphate; Adenosine 3',5'-cyclic phosphate; Adenosine 3',5'-cyclophosphate; Adenosine 3',5'-monophosphate; Adenosine 3,5'-cyclic monophosphorate; Adenosine 3,5'-cyclic monophosphoric acid; Adenosine cyclic monophosphate; Cyclic 3',5'-AMP; Cyclic 3',5'-adenylate; Cyclic 3',5'-adenylic acid; Cyclic adenosine 3',5'-phosphate; adenosine cyclic-monophosphate; adenosine-cyclic-phosphate; adenosine-cyclic-phosphoric-acid; cAMP
HMDB00250   Pyrophosphate   (4-)Diphosphoric acid ion; (P2O74-)Diphosphate; Diphosphate; Pyrometaphosphate; Pyrophosphate; Pyrophosphate tetraanion; Pyrophosphate(4-) ion; Pyrophosphic acid
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000155897 Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145] Xenopus_tropicalisone2one ENSXETG00000022723Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Pan_troglodytesone2one ENSPTRG00000020589Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]ADCY8
Pongo_pygmaeusone2one ENSPPYG00000018885Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Macaca_mulattaone2one ENSMMUG00000010440Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Tursiops_truncatusone2one ENSTTRG00000013440Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Equus_caballusone2one ENSECAG00000024601Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Microcebus_murinusone2one ENSMICG00000000266Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Otolemur_garnettiione2one ENSOGAG00000001459Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Bos_taurusone2one ENSBTAG00000014600Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]ADCY8
Tarsius_syrichtaone2one ENSTSYG00000011776Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Loxodonta_africanaone2one ENSLAFG00000009118Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Vicugna_pacosone2one ENSVPAG00000001426Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Canis_familiarisone2one ENSCAFG00000001097Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]ADCY8
Cavia_porcellusone2one ENSCPOG00000007195Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Tupaia_belangerione2one ENSTBEG00000000548Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000002685Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000007186Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Dipodomys_ordiione2one ENSDORG00000006484Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P97490][hgnc]
Ochotona_princepsone2one ENSOPRG00000010478Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Sorex_araneusone2one ENSSARG00000003822Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000002616Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Rattus_norvegicusone2one ENSRNOG00000004890Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin- activated adenylyl cyclase). [Source:UniProtKB/Swiss-Prot;Acc:P40146][hgnc]Adcy8
Erinaceus_europaeusone2one ENSEEUG00000008987Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Mus_musculusone2one ENSMUSG00000022376Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P97490][hgnc]Adcy8
Echinops_telfairione2one ENSETEG00000002065Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Myotis_lucifugusone2one ENSMLUG00000012194Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Procavia_capensisone2one ENSPCAG00000007914Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000002439Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Monodelphis_domesticaone2one ENSMODG00000001430Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000008103Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Gallus_gallusone2one ENSGALG00000016298Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]ADCY8
Tetraodon_nigroviridisone2one ENSTNIG00000008003Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Oryzias_latipesone2one ENSORLG00000006410Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Danio_rerioone2one ENSDARG00000031783Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Takifugu_rubripesone2one ENSTRUG00000001746Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Gasterosteus_aculeatusapprent_one2one ENSGACG00000010084Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]
Ciona_savignyione2many ENSCSAVG00000000207[hgnc]
Ciona_savignyione2many ENSCSAVG00000001557[hgnc]
Ciona_intestinalisone2one ENSCING00000000490[hgnc]
Felis_catusapprent_one2one ENSFCAG00000006436Adenylate cyclase type 8 (EC 4.6.1.1) (Adenylate cyclase type VIII) (ATP pyrophosphate-lyase 8) (Adenylyl cyclase 8) (Ca(2+)/calmodulin-activated adenylyl cyclase) [Source:UniProtKB/Swiss-Prot;Acc:P40145][hgnc]