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Summary sheet information for Effector 'Adenylate cyclase 9-Homo sapiens'
Name Adenylate cyclase 9-Homo sapiens
Description RecName: Full=Adenylate cyclase type 9; EC=4.6.1.1;AltName: Full=Adenylate cyclase type IX;AltName: Full=ATP pyrophosphate-lyase 9;AltName: Full=Adenylyl cyclase 9
Class
Family Cyclases
Sub_family Adenylate cyclases
type Adenylate cyclase 9
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 16
Gene Start: 3952658
Gene End: 4106187
Ensembl Contig View
Ensembl Genes:
ENSG00000162104
EMBL:
EMBL ID  Description
AB011092  Homo sapiens mRNA for KIAA0520 protein, partial cds.
AF036927  Homo sapiens adenylyl cyclase type IX mRNA, complete cds.
AJ133123  Homo sapiens mRNA for adenylyl cyclase type IX
AY028949  Homo sapiens adenylate cyclase type 9 (ADCY9) gene, exon 2.
AY028950  Homo sapiens adenylate cyclase type 9 (ADCY9) gene, exon 3.
AY028951  Homo sapiens adenylate cyclase type 9 (ADCY9) gene, exon 4.
AY028952  Homo sapiens adenylate cyclase type 9 (ADCY9) gene, exon 5.
AY028953  Homo sapiens adenylate cyclase type 9 (ADCY9) gene, exon 6.
AY028954  Homo sapiens adenylate cyclase type 9 (ADCY9) gene, exon 7.
AY028955  Homo sapiens adenylate cyclase type 9 (ADCY9) gene, exon 8.
AY028956  Homo sapiens adenylate cyclase type 9 (ADCY9) gene, exon 9.
AY028957  Homo sapiens adenylate cyclase type 9 (ADCY9) gene, exon 10.
AY028959  Homo sapiens adenylate cyclase type 9 (ADCY9) gene, exons 11a, 11b, and complete cds.
BC136657  Homo sapiens adenylate cyclase 9, mRNA (cDNA clone MGC:168270 IMAGE:9020647), complete cds.
BC136658  Homo sapiens adenylate cyclase 9, mRNA (cDNA clone MGC:168271 IMAGE:9020648), complete cds.
BC151207  Homo sapiens adenylate cyclase 9, mRNA (cDNA clone MGC:164747 IMAGE:40147127), complete cds.
BC151229  Homo sapiens adenylate cyclase 9, mRNA (cDNA clone MGC:166903 IMAGE:9007273), complete cds.
CH471112  Homo sapiens 211000035837318 genomic scaffold, whole genome shotgun sequence.
DQ005545  Homo sapiens adenylyl cyclase type 9 (ADCY9) mRNA, complete cds.
DQ008441  Homo sapiens adenylyl cyclase type 9 mRNA, complete cds.

EntrezGene:
ID  Description
ADCY9  adenylate cyclase 9
RefSeq DNA:
ID  Description
NM_001116  Homo sapiens adenylate cyclase 9 (ADCY9), mRNA.

UniGene:
ID  Description
Hs.391860  KIAA0520 protein
Hs.605958  Transcribed locus
Hs.610484  Transcribed locus

Proteins
Ensembl Proteins:
ENSP00000294016
Entrez Proteins:
AAC24201.1; AAI36658.1; AAI36659.1; AAI51208.1; AAI51230.1; AAK29464.1; AAY21237.1; AAY27880.1; BAA25446.3; CAB65084.1; EAW85331.1
RefSeq Proteins:
ID  Description
NP_001107  adenylate cyclase 9 [Homo sapiens].

UniProt:
ID  Description
A7E2V5  SubName: Full=Adenylate cyclase 9; SubName: Full=Adenylate cyclase 9, isoform CRA_a;
A7E2X2  SubName: Full=ADCY9 protein;
O60503  RecName: Full=Adenylate cyclase type 9; EC=4.6.1.1; AltName: Full=Adenylate cyclase type IX; AltName: Full=ATP pyrophosphate-lyase 9; AltName: Full=Adenylyl cyclase 9;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Adenylate cyclase 9-Homo sapiens    

InterPro:
ID  Name
IPR001054  A/G_cyclase
Pfam:
ID  Description
Guanylate_cyc  Adenylate and Guanylate cyclase catalytic domain

Structure
PDB:
ID
HSSP:
ID  Description
1ab8  LYASE
1azs  COMPLEX (LYASE/HYDROLASE)
1cjk  LYASE/LYASE/SIGNALING PROTEIN
1cjt  LYASE/LYASE/SIGNALING PROTEIN
1cju  LYASE/LYASE/SIGNALING PROTEIN
1cjv  LYASE/LYASE/SIGNALING PROTEIN
1cs4  LYASE/LYASE/SIGNALING PROTEIN
1cul  LYASE/LYASE/SIGNALING PROTEIN
1tl7  LYASE
1u0h  LYASE
1wc1  LYASE
1wc3  LYASE
1wc4  LYASE
1wc5  LYASE
1wc6  LYASE
1yk9  LYASE
2bw7  LYASE
2gvd  LYASE
2gvz  LYASE
3c14  LYASE/LYASE INHIBITOR
3c15  LYASE/LYASE INHIBITOR
3c16  LYASE/LYASE INHIBITOR
3et6  LYASE
PSSH:
ID  Description
A7E2X2  UNKNOWN
A7E2V5  UNKNOWN
O60503  UNKNOWN
Diseases
OMIM:
OMIM ID  Name  Alt Name
603302  ADENYLATE CYCLASE 9; ADCY9   ADENYLYL CYCLASE 9
Gene Ontology
GO:
GO ID  Description
GO:0000287  magnesium ion binding
GO:0003700  transcription factor activity
GO:0004016  adenylate cyclase activity
GO:0005634  nucleus
GO:0005887  integral to plasma membrane
GO:0006171  cAMP biosynthetic process
GO:0007242  intracellular signaling cascade
GO:0009190  cyclic nucleotide biosynthetic process
GO:0016020  membrane
GO:0016849  phosphorus-oxygen lyase activity
GO:0045449  regulation of transcription
Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04020  Calcium signaling pathway
hsa04062  Chemokine signaling pathway
hsa05414  Dilated cardiomyopathy
hsa04540  Gap junction
hsa04912  GnRH signaling pathway
hsa04916  Melanogenesis
hsa04114  Oocyte meiosis
hsa04914  Progesterone-mediated oocyte maturation
hsa00230  Purine metabolism
hsa04270  Vascular smooth muscle contraction
hsa04962  Vasopressin-regulated water reabsorption
hsa05110  Vibrio cholerae infection

Panther:
ID  Description
P00026  Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
P05731  GABA-B receptor II signaling
P00019  Endothelin signaling pathway
Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
HMDB00538   Adenosine triphosphate   5'-(tetrahydrogen triphosphate) Adenosine; 5'-ATP; ATP; Adenosine 5'-triphosphate; Adenosine 5'-triphosphorate; Adenosine 5'-triphosphoric acid; Adenosine triphosphate; Adenosine triphosphic acid; Adenylpyrophosphorate; Adenylpyrophosphoric acid; Adephos; Adetol; Adynol; Atipi; Atriphos; Cardenosine; Fosfobion; Glucobasin; Myotriphos; Phosphobion; Striadyne; Triadenyl; Triphosphaden; Triphosphoric acid adenosine ester
HMDB00058   Cyclic AMP   Cyclic AMP; 3'5'-cyclic AMP; 6-(6-Amino-9H-purin-9-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide; Acrasin; Adenosine 3',5'-cyclic monophosphate; Adenosine 3',5'-cyclic phosphate; Adenosine 3',5'-cyclophosphate; Adenosine 3',5'-monophosphate; Adenosine 3,5'-cyclic monophosphorate; Adenosine 3,5'-cyclic monophosphoric acid; Adenosine cyclic monophosphate; Cyclic 3',5'-AMP; Cyclic 3',5'-adenylate; Cyclic 3',5'-adenylic acid; Cyclic adenosine 3',5'-phosphate; adenosine cyclic-monophosphate; adenosine-cyclic-phosphate; adenosine-cyclic-phosphoric-acid; cAMP
HMDB00250   Pyrophosphate   (4-)Diphosphoric acid ion; (P2O74-)Diphosphate; Diphosphate; Pyrometaphosphate; Pyrophosphate; Pyrophosphate tetraanion; Pyrophosphate(4-) ion; Pyrophosphic acid
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000162104 Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503] Pan_troglodytesone2one ENSPTRG00000007711Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000007052Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Macaca_mulattaone2many ENSMMUG00000001243[hgnc]
Macaca_mulattaone2many ENSMMUG00000029965[hgnc]
Tarsius_syrichtaone2one ENSTSYG00000009331Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Microcebus_murinusone2one ENSMICG00000017662Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Otolemur_garnettiione2one ENSOGAG00000002315Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Equus_caballusone2one ENSECAG00000024355Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]LOC100066046
Felis_catusone2one ENSFCAG00000006983Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000006582Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000007904Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Myotis_lucifugusone2one ENSMLUG00000005722Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Canis_familiarisone2one ENSCAFG00000019237Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]ADCY9
Tupaia_belangerione2one ENSTBEG00000015644Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Tursiops_truncatusone2one ENSTTRG00000002708Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Dipodomys_ordiione2one ENSDORG00000009031Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) (Adenylyl cyclase type 10) (ACTP10) [Source:UniProtKB/Swiss-Prot;Acc:P51830][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000005041Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Cavia_porcellusone2one ENSCPOG00000019749Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Vicugna_pacosone2one ENSVPAG00000007717Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Ochotona_princepsone2one ENSOPRG00000000466Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Mus_musculusone2one ENSMUSG00000005580Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) (Adenylyl cyclase type 10) (ACTP10) [Source:UniProtKB/Swiss-Prot;Acc:P51830][hgnc]Adcy9
Rattus_norvegicusone2one ENSRNOG00000005297Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) (Adenylyl cyclase type 10) (ACTP10) [Source:UniProtKB/Swiss-Prot;Acc:P51830][hgnc]
Bos_taurusone2one ENSBTAG00000016629Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Loxodonta_africanaone2one ENSLAFG00000004165Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Procavia_capensisone2one ENSPCAG00000000188Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000013741Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Sorex_araneusone2one ENSSARG00000007851Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Echinops_telfairione2one ENSETEG00000003559Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000002313Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000005848Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]100080569
Monodelphis_domesticaone2one ENSMODG00000016382Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Gallus_gallusone2one ENSGALG00000007779Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9). [Source:UniProtKB/Swiss-Prot;Acc:Q9DGG6][hgnc]ADCY9
Xenopus_tropicalisone2one ENSXETG00000017315Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Takifugu_rubripesone2many ENSTRUG00000005738Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000011339Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Oryzias_latipesone2many ENSORLG00000008296Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000018754Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Oryzias_latipesone2many ENSORLG00000015080Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Danio_rerioone2one ENSDARG00000069419Novel protein similar to vertbrate adenylate cyclase 9 (ADCY9) (Fragment). [Source:UniProtKB/TrEMBL;Acc:A3KQN1][hgnc]LOC566706
Takifugu_rubripesone2many ENSTRUG00000013013Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000019800Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000014097Adenylate cyclase type 9 (EC 4.6.1.1) (Adenylate cyclase type IX) (ATP pyrophosphate-lyase 9) (Adenylyl cyclase 9) [Source:UniProtKB/Swiss-Prot;Acc:O60503][hgnc]