Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Summary sheet information for Effector 'ATP-sensitive inward rectifier potassium channel 14-Homo sapiens'

Name

ATP-sensitive inward rectifier potassium channel 14-Homo sapiens

Description

"RecName: Full=ATP-sensitive inward rectifier potassium channel 14;AltName: Full=Potassium channel, inwardly rectifying subfamily J member 14;AltName: Full=Inward rectifier K(+) channel Kir2.4; Short=IRK4;"

Class

Family

Ion channels

Sub_family

ATP-sensitive inward rectifier potassium channels

type

ATP-sensitive inward rectifier potassium channel 14

Protein features link

Protein Information from Dasty2 DAS Client

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level

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Genes

Gene Location:

Chromosome	: 19
Gene Start	: 53650578
Gene End	: 53661179
Ensembl Contig View

Ensembl Genes:

ENSG00000182324

EMBL:

EMBL ID		Description
AF081466		Homo sapiens inward rectifier potassium channel (KIR2.4) mRNA, complete cds.
AF181988		Homo sapiens inwardly rectifying potassium channel Kir2.4 (KCNJ14) gene, complete cds.
BC035918		Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 14, mRNA (cDNA clone MGC:46111 IMAGE:5531571), complete cds.

EntrezGene:

ID		Description
KCNJ14		potassium inwardly-rectifying channel, subfamily J, member 14

RefSeq DNA:

ID		Description
NM_013348		Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 14 (KCNJ14), transcript variant 1, mRNA.
NM_170720		Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 14 (KCNJ14), transcript variant 2, mRNA.

UniGene:

ID		Description
Hs.590945		Potassium inwardly-rectifying channel, subfamily J, member 14 (KCNJ14), transcript variant 2, mRNA

Proteins

Ensembl Proteins:

ENSP00000341479; ENSP00000375756

Entrez Proteins:

AAD51376.1; AAF97619.1; AAH35918.1

RefSeq Proteins:

ID		Description
NP_037480		potassium inwardly-rectifying channel J14 [Homo sapiens].
NP_733838		potassium inwardly-rectifying channel J14 [Homo sapiens].

UniProt:

ID		Description
Q9UNX9		RecName: Full=ATP-sensitive inward rectifier potassium channel 14; AltName: Full=Potassium channel, inwardly rectifying subfamily J member 14; AltName: Full=Inward rectifier K(+) channel Kir2.4; Short=IRK4;

Domains

SMART:

- Hyperlink to SMART;

- Hyperlink to ENSEMBL

ATP-sensitive inward rectifier potassium channel 14-Homo sapiens

InterPro:

ID		Name
IPR016449		K_chnl_inward-rec_Kir
IPR013521		K_chnl_inward-rec_Kir_Cr2
IPR001838		K_chnl_inward-rec_Kir-like
IPR013518		K_chnl_inward-rec_Kir_cyto

Pfam:

ID		Description
IRK		Inward rectifier potassium channel

Structure

PDB:

HSSP:

ID		Description
1n9p		METAL TRANSPORT
1p7b		METAL TRANSPORT
1u4e		METAL TRANSPORT
1u4f		ALLERGEN
2e4f		TRANSPORT PROTEIN
2gix		METAL TRANSPORT
2qks		METAL TRANSPORT

PSSH:

ID		Description
Q9UNX9		UNKNOWN

Diseases

OMIM:

OMIM ID		Name		Alt Name
603953		POTASSIUM INWARDLY-RECTIFYING CHANNEL, SUBFAMILY J, MEMBER 14; KCNJ14		KIR2.4

Gene Ontology

GO:

GO ID		Description
GO:0005242		inward rectifier potassium channel activity
GO:0005244		voltage-gated ion channel activity
GO:0006811		ion transport
GO:0006813		potassium ion transport
GO:0008076		voltage-gated potassium channel complex
GO:0016020		membrane
GO:0016021		integral to membrane
GO:0030955		potassium ion binding

Pathway

KEGG:

KEGG PATHWAY ID

Name

Panther:

Description

Chemicals

DrugBank:

Name

Synonyms

HMDB:

Name

Synonyms

Orthology

Orthology Relations:

Gene	Gene Description	Organism	Orthology type	Orthologs	Orthologs Description
ENSG00000182324	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9]	Caenorhabditis_elegans	many2many	R03E9.4	Inward rectifier potassium channel irk-1. [Source:UniProtKB/Swiss-Prot;Acc:P52192][hgnc]irk-1
		Caenorhabditis_elegans	many2many	M02A10.2	irk-2 encodes an inwardly rectifying potassium channel based on sequence homology to the the human potassium channel genes KCNJ1/KCNJ2. [Source: WormBase][hgnc]irk-2
		Aedes_aegypti	many2many	AAEL008931	inwardly rectifying k+ channel,[hgnc]
		Aedes_aegypti	many2many	AAEL013373	inwardly rectifying k+ channel,[hgnc]
		Anopheles_gambiae	many2many	AGAP001284	[hgnc]AgaP_ENSANGG00000024811
		Pan_troglodytes	one2one	ENSPTRG00000011237	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]KCNJ14
		Macaca_mulatta	one2one	ENSMMUG00000001792	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Dasypus_novemcinctus	one2one	ENSDNOG00000003748	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Tupaia_belangeri	one2one	ENSTBEG00000010667	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Canis_familiaris	one2one	ENSCAFG00000004001	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]KCNJ14
		Equus_caballus	one2one	ENSECAG00000009854	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Tarsius_syrichta	one2one	ENSTSYG00000008338	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Microcebus_murinus	one2one	ENSMICG00000008901	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Bos_taurus	one2one	ENSBTAG00000000082	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]KCNJ14
		Loxodonta_africana	one2one	ENSLAFG00000007497	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Pteropus_vampyrus	one2one	ENSPVAG00000001986	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Oryctolagus_cuniculus	one2one	ENSOCUG00000008998	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Cavia_porcellus	one2one	ENSCPOG00000002292	Inwardly-rectifying potassium channel Kir2.4. [Source:UniProtKB/TrEMBL;Acc:Q9EP58][hgnc]
		Procavia_capensis	one2one	ENSPCAG00000003348	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Otolemur_garnettii	one2one	ENSOGAG00000005700	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Myotis_lucifugus	one2one	ENSMLUG00000014869	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Echinops_telfairi	one2one	ENSETEG00000013240	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Spermophilus_tridecemlineatus	one2one	ENSSTOG00000000271	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Tursiops_truncatus	one2one	ENSTTRG00000007871	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Ochotona_princeps	one2one	ENSOPRG00000013111	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Mus_musculus	one2one	ENSMUSG00000058743	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q8JZN3][hgnc]Kcnj14
		Rattus_norvegicus	one2one	ENSRNOG00000021056	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q8JZN3][hgnc]
		Sorex_araneus	one2one	ENSSARG00000002114	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Dipodomys_ordii	one2one	ENSDORG00000012823	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q8JZN3][hgnc]
		Ornithorhynchus_anatinus	one2one	ENSOANG00000008163	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]100092312
		Xenopus_tropicalis	one2one	ENSXETG00000004575	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Gasterosteus_aculeatus	one2one	ENSGACG00000011616	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Oryzias_latipes	one2one	ENSORLG00000010708	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Takifugu_rubripes	one2one	ENSTRUG00000015539	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Tetraodon_nigroviridis	one2one	ENSTNIG00000008074	ATP-sensitive inward rectifier potassium channel 14 (Potassium channel, inwardly rectifying subfamily J member 14) (Inward rectifier K(+) channel Kir2.4) (IRK4) [Source:UniProtKB/Swiss-Prot;Acc:Q9UNX9][hgnc]
		Aedes_aegypti	many2many	AAEL008932	inwardly rectifying k+ channel,[hgnc]
		Drosophila_melanogaster	many2many	FBgn0039061	[hgnc]Ir
		Anopheles_gambiae	many2many	AGAP001280	[hgnc]AgaP_ENSANGG00000017854
		Drosophila_melanogaster	many2many	FBgn0039081	[hgnc]Irk2
		Aedes_aegypti	many2many	AAEL008928	inwardly rectifying k+ channel,[hgnc]
		Anopheles_gambiae	many2many	AGAP001283	[hgnc]AgaP_ENSANGG00000017795
		Anopheles_gambiae	many2many	AGAP001281	[hgnc]AgaP_ENSANGG00000020396