Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Summary sheet information for GPCR 'ADRENERGIC RECEPTORS_A2C_Homo sapiens'

Name

ADRENERGIC RECEPTORS_A2C_Homo sapiens

Description

RecName: Full=Alpha-2C adrenergic receptor;AltName: Full=Alpha-2C adrenoreceptor;AltName: Full=Alpha-2C adrenoceptor;AltName: Full=Alpha-2 adrenergic receptor subtype C4

Class

CLASS A

Family

ADRENERGIC RECEPTORS

Sub_family

A2C

type

Protein features link

Protein Information from Dasty2 DAS Client

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level

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Genes

Gene Location:

Chromosome	: 4
Gene Start	: 3738094
Gene End	: 3740051
Ensembl Contig View

Ensembl Genes:

ENSG00000184160

EMBL:

EMBL ID		Description
AC141928		Homo sapiens fosmid clone XXFOS-85085A9 from 4, complete sequence.
AF280399		Homo sapiens alpha 2C adrenergic receptor (ADRA2C) gene, complete cds.
AF280400		Homo sapiens alpha 2C adrenergic receptor variant (ADRA2C) gene, complete cds.
AY455666		Homo sapiens adrenergic receptor alpha 2C (ADRA2C) gene, complete cds.
AY605898		Homo sapiens haplotype 1 alpha2C adrenergic receptor (ADRA2C) gene, complete cds.
BC142625		Homo sapiens adrenergic, alpha-2C-, receptor, mRNA (cDNA clone MGC:164798 IMAGE:40147492), complete cds.
D13538		Homo sapiens alpha2CII-adrenergic receptor gene, complete cds.
EU332833		Homo sapiens adrenergic, alpha-2C-, receptor (ADRA2C) gene, complete cds.
J03853		Human kidney alpha-2-adrenergic receptor mRNA, complete cds.
U72648		Homo sapiens alpha2-C4-adrenergic receptor gene, complete cds.
X59684		H.sapiens DNA for alpha2-1.8 adrenergic receptor gene

EntrezGene:

ID		Description
ADRA2C		adrenergic, alpha-2C-, receptor

RefSeq DNA:

ID		Description
NM_000683		Homo sapiens adrenergic, alpha-2C-, receptor (ADRA2C), mRNA.

UniGene:

ID		Description
Hs.123022		Kidney alpha-2-adrenergic receptor

Proteins

Ensembl Proteins:

ENSP00000386069

Entrez Proteins:

AAA35513.1; AAC78723.1; AAG28076.1; AAG28077.1; AAI42626.1; AAR18071.1; AAT02221.1; AAY41059.1; ABY87522.1; BAA02737.1

RefSeq Proteins:

ID		Description
NP_000674		alpha-2C-adrenergic receptor [Homo sapiens].

UniProt:

ID		Description
Q4W594		SubName: Full=Putative uncharacterized protein ADRA2C (Adrenergic, alpha-2C-, receptor);
P18825		RecName: Full=Alpha-2C adrenergic receptor; AltName: Full=Alpha-2C adrenoreceptor; AltName: Full=Alpha-2C adrenoceptor; AltName: Full=Alpha-2 adrenergic receptor subtype C4;

Domains

SMART:

- Hyperlink to SMART;

- Hyperlink to ENSEMBL

InterPro:

ID		Name
IPR000276		GPCR_Rhodpsn
IPR002233		Adrnrgc_rcpt
IPR000735		Adren_rcpt_A2C
IPR017452		GPCR_Rhodpsn_supfam
IPR015695		Adren_rcpt_A2A/B/C

Pfam:

ID		Description
7tm_1		7 transmembrane receptor (rhodopsin family)

Structure

PDB:

HSSP:

ID		Description
1hll		MEMBRANE PROTEIN
1ho9		MEMBRANE PROTEIN
1hod		MEMBRANE PROTEIN
1hof		MEMBRANE PROTEIN
2vt4		RECEPTOR

PSSH:

ID		Description
Q4W594		UNKNOWN
P18825		UNKNOWN

Diseases

OMIM:

OMIM ID		Name		Alt Name
104250		ALPHA-2C-ADRENERGIC RECEPTOR; ADRA2C		ALPHA-2-ADRENERGIC RECEPTOR, RENAL TYPE

Gene Ontology

GO:

GO ID		Description
GO:0000187		activation of MAPK activity
GO:0001584		rhodopsin-like receptor activity
GO:0003677		DNA binding
GO:0004872		receptor activity
GO:0004879		ligand-dependent nuclear receptor activity
GO:0004930		G-protein coupled receptor activity
GO:0004935		adrenoceptor activity
GO:0004938		alpha2-adrenergic receptor activity
GO:0004952		dopamine receptor activity
GO:0004977		melanocortin receptor activity
GO:0004981		muscarinic acetylcholine receptor activity
GO:0004989		octopamine receptor activity
GO:0005515		protein binding
GO:0005634		nucleus
GO:0005768		endosome
GO:0005886		plasma membrane
GO:0005887		integral to plasma membrane
GO:0006355		regulation of transcription, DNA-dependent
GO:0007165		signal transduction
GO:0007186		G-protein coupled receptor protein signaling pathway
GO:0007267		cell-cell signaling
GO:0016020		membrane
GO:0016021		integral to membrane

Pathway

KEGG:

KEGG PATHWAY ID		Name
hsa04080		Neuroactive ligand-receptor interaction

Panther:

ID		Description
P00026		Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway

Chemicals

DrugBank:

ID	Name	Synonyms
DB01170	Guanethidine	Guanethidine Monosulfate; Guanethidine Sulphae
DB04948	Lofexidine	2-(1-(2,6-Dichlorophenoxy)ethyl)-4,5-dihydro-1H-imidazole; 2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline; Lofexidina [inn-spanish]; Lofexidine hydrochloride; Lofexidinum [inn-latin]; lofexidine
DB06262	Droxidopa	Droxydopa; L-DOPS; L-dihydroxyphenylserine; L-threo-3,4-dihydroxyphenylserine
DB00217	Bethanidine	Betanidin; Betanidine; Bethanidine sulfate
DB00368	Norepinephrine	Arterenol; L-Norepinephrine; L-noradrenaline; Noradrenaline; Norepinephrine
DB04840	Debrisoquin	Debrisochinum; Debrisoquin hemisulfate; Debrisoquin sulfate; Debrisoquina [inn-spanish]; Debrisoquine; Debrisoquine sulfate; Debrisoquinum [inn-latin]; Isocaramidine; Isocaramidine sulfate
DB00484	Brimonidine	Brimonidine tartrate; Bromoxidine
DB01392	Yohimbine	Yohimbin
DB00226	Guanadrel Sulfate	Guanadrelum [INN-Latin]
DB00800	Fenoldopam	Fenodopam mesylate; Fenoldopam mesylate; Fenoldopamum [Latin]

HMDB:

Name

Synonyms

Other GPCR resources

Links to other GPCR resources

GPCRDB | GPCR-OKB | GLIDA

Orthology

Orthology Relations:

Gene	Gene Description	Organism	Orthology type	Orthologs	Orthologs Description
ENSG00000184160	Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825]	Pan_troglodytes	one2one	ENSPTRG00000034025	PREDICTED: Pan troglodytes similar to alpha 2C adrenergic receptor (LOC465178), mRNA. [Source:RefSeq_dna;Acc:XR_025329][hgnc]LOC465178
		Canis_familiaris	one2one	ENSCAFG00000014602	Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
		Rattus_norvegicus	one2one	ENSRNOG00000009299	Alpha-2C adrenergic receptor (Alpha-2C adrenoceptor) (Alpha-2C adrenoreceptor) (Alpha-2 adrenergic receptor subtype C4). [Source:UniProtKB/Swiss-Prot;Acc:P22086][hgnc]Adra2c
		Mus_musculus	one2one	ENSMUSG00000045318	Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:Q01337][hgnc]LOC100045767
		Macaca_mulatta	one2one	ENSMMUG00000014781	Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
		Monodelphis_domestica	one2one	ENSMODG00000003290	Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
		Gallus_gallus	one2one	ENSGALG00000015608	Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]ADRA2C
		Xenopus_tropicalis	one2one	ENSXETG00000015427	Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
		Oryzias_latipes	one2many	ENSORLG00000006057	Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
		Gasterosteus_aculeatus	one2many	ENSGACG00000019417	Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
		Tetraodon_nigroviridis	one2many	ENSTNIG00000012046	Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
		Tetraodon_nigroviridis	one2many	ENSTNIG00000010151	Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
		Gasterosteus_aculeatus	one2many	ENSGACG00000018364	Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
		Takifugu_rubripes	one2many	ENSTRUG00000003591	Alpha2 c1 adrenergic receptor. [Source:UniProtKB/TrEMBL;Acc:Q8JG06][hgnc]
		Takifugu_rubripes	one2many	ENSTRUG00000010714	Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
		Oryzias_latipes	one2many	ENSORLG00000014425	Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
		Equus_caballus	apprent_one2one	ENSECAG00000006948	Alpha-2B adrenergic receptor (Alpha-2B adrenoceptor) (Alpha-2B adrenoreceptor) (Fragment). [Source:UniProtKB/Swiss-Prot;Acc:O77721][hgnc]LOC100051684
		Pongo_pygmaeus	apprent_one2one	ENSPPYG00000012061	Alpha-2C adrenergic receptor (Alpha-2C adrenoreceptor) (Alpha-2C adrenoceptor) (Alpha-2 adrenergic receptor subtype C4) [Source:UniProtKB/Swiss-Prot;Acc:P18825][hgnc]
		Bos_taurus	apprent_one2one	ENSBTAG00000009510	Alpha-2B adrenergic receptor (Alpha-2B adrenoceptor) (Alpha-2B adrenoreceptor) (Fragment). [Source:UniProtKB/Swiss-Prot;Acc:O77700][hgnc]ADRA2B
		Cavia_porcellus	apprent_one2one	ENSCPOG00000013367	Alpha-2B adrenergic receptor (Alpha-2B adrenoreceptor) (Alpha-2B adrenoceptor). [Source:UniProtKB/Swiss-Prot;Acc:Q60475][hgnc]