Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Summary sheet information for Effector 'Voltage dependent R type calcium channel-Homo sapiens'

Name

Voltage dependent R type calcium channel-Homo sapiens

Description

"RecName: Full=Voltage-dependent R-type calcium channel subunit alpha-1E;AltName: Full=Voltage-gated calcium channel subunit alpha Cav2.3;AltName: Full=Calcium channel, L type, alpha-1 polypeptide, isoform 6;AltName: Full=Brain calcium channel II; Short=BII;"

Class

Family

Ion channels

Sub_family

Voltage dependent calcium channels

type

Voltage dependent R type calcium channel

Protein features link

Protein Information from Dasty2 DAS Client

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level

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Genes

Gene Location:

Chromosome	: 1
Gene Start	: 179648918
Gene End	: 180037339
Ensembl Contig View

Ensembl Genes:

ENSG00000198216

EMBL:

EMBL ID		Description
AB209499		Homo sapiens mRNA for calcium channel, voltage-dependent, alpha 1E subunit variant protein.
AF152379		Homo sapiens voltage-gated calcium channel alpha 1E subunit (CACNA1E) gene, exons 13 and 14 and partial cds.
AF223391		Homo sapiens calcium channel alpha1E subunit (CACNA1E) gene, exons 7-49, and partial cds, alternatively spliced.
AF239258		Homo sapiens calcium channel alpha1E subunit (CACNA1E) gene, exons 2 and 3.
AF239259		Homo sapiens calcium channel alpha1E subunit (CACNA1E) gene, exons 4, 5, and 6.
AJ276502		Homo sapiens partial CACNA1E gene for voltage-dependent calcium channel alpha 1E subunit, exon 1
AL160059		Human DNA sequence from clone RP11-94G15 on chromosome 1 Contains the 5' end of the CACNA1E gene for calcium channel voltage-dependent alpha 1E subunit.
AL161734		Human DNA sequence from clone RP11-33M22 on chromosome 1q25.2-31.2 Contains the 3' end of the CACNA1E gene for calcium channel voltage-dependent alpha 1E subunit.
AL359270		Human DNA sequence from clone RP11-494J9 on chromosome 1 Contains parrt of the CACNA1E gene for calcium channel voltage-dependent alpha 1E subunit.
AL590998		Human DNA sequence from clone RP4-677A15 on chromosome 1 Contains parrt of the CACNA1E gene for calcium channel voltage-dependent alpha 1E subunit.
L27745		Homo sapiens voltage-operated calcium channel, alpha-1 subunit mRNA, complete cds.
L29384		Homo sapiens (clone pcDNA-alpha1E-1) voltage-dependent calcium channel alpha-1E-1 subunit mRNA, complete cds.
L29385		Homo sapiens (clone pcDNA-alpha1E-3) voltage-dependent calcium channel alpha-1E-3 subunit mRNA, complete cds.

EntrezGene:

ID		Description
CACNA1E		calcium channel, voltage-dependent, R type, alpha 1E subunit

RefSeq DNA:

ID		Description
NM_000721		Homo sapiens calcium channel, voltage-dependent, R type, alpha 1E subunit (CACNA1E), mRNA.

UniGene:

ID		Description
Hs.611396		Gm139

Proteins

Ensembl Proteins:

ENSP00000353222; ENSP00000356542; ENSP00000356545; ENSP00000356539; ENSP00000351101; ENSP00000350183

Entrez Proteins:

AAA59204.1; AAA59205.1; AAA72125.1; AAD38389.1; AAF37687.1; AAF37688.1; BAD92736.1; CAB81554.1; CAH72675.1; CAH72676.1; CAH72677.1; CAI14653.1; CAI14654.1; CAI14655.1; CAI17081.1; CAI17082.1; CAI17083.1; CAI22327.1; CAI22328.1; CAI22329.1

RefSeq Proteins:

ID		Description
NP_000712		calcium channel, voltage-dependent, R type, alpha 1E subunit [Homo sapiens].

UniProt:

ID		Description
Q15878-2		UNKNOWN
Q15878-3		UNKNOWN
B1AM12		SubName: Full=Calcium channel, voltage-dependent, R type, alpha 1E subunit;
B1AM13		SubName: Full=Calcium channel, voltage-dependent, R type, alpha 1E subunit;
B1AM14		UNKNOWN
Q59FG1		SubName: Full=Calcium channel, voltage-dependent, alpha 1E subunit variant; Flags: Fragment;
Q9NY05		SubName: Full=Voltage-dependent calcium channel alpha 1E subunit; Flags: Fragment;
Q9NYZ5		SubName: Full=Calcium channel alpha1E subunit, delta19 delta40 delta46 splice variant; Flags: Fragment;
Q9NYZ6		SubName: Full=Calcium channel alpha1E subunit, delta39 splice variant; Flags: Fragment;
Q9UN68		SubName: Full=Voltage-gated calcium channel alpha 1E subunit; Flags: Fragment;
Q15878		RecName: Full=Voltage-dependent R-type calcium channel subunit alpha-1E; AltName: Full=Voltage-gated calcium channel subunit alpha Cav2.3; AltName: Full=Calcium channel, L type, alpha-1 polypeptide, isoform 6; AltName: Full=Brain calcium channel II; Short=BII;

Domains

SMART:

- Hyperlink to SMART;

- Hyperlink to ENSEMBL

Voltage dependent R type calcium channel-Homo sapiens

InterPro:

ID		Name
IPR005821		Ion_trans
IPR002048		EF_hand_Ca_bd
IPR014873		VDCC_a1su_IQ
IPR005449		VDCC_R_a1su
IPR002077		VDCCAlpha1

Pfam:

ID		Description
Ion_trans		Ion transport protein
Ion_trans		Ion transport protein
Ca_chan_IQ		Voltage gated calcium channel IQ domain

Structure

PDB:

3BXL

HSSP:

ID		Description
3bxk		MEMBRANE PROTEIN, SIGNALING PROTEIN
3bxl		MEMBRANE PROTEIN, SIGNALING PROTEIN
3dvj		MEMBRANE PROTEIN
3dvk		MEMBRANE PROTEIN
3dvm		MEMBRANE PROTEIN

PSSH:

ID		Description
Q59FG1		UNKNOWN
Q9NYZ5		UNKNOWN
Q9NYZ6		UNKNOWN
Q15878		UNKNOWN

Diseases

OMIM:

OMIM ID		Name		Alt Name
601013		CALCIUM CHANNEL, VOLTAGE-DEPENDENT, ALPHA-1E SUBUNIT; CACNA1E		CALCIUM CHANNEL, L TYPE, ALPHA-1 POLYPEPTIDE, ISOFORM 6; CACNL1A6 CaV2.3 CALCIUM CHANNEL, R TYPE

Gene Ontology

GO:

GO ID		Description
GO:0005216		ion channel activity
GO:0005244		voltage-gated ion channel activity
GO:0005245		voltage-gated calcium channel activity
GO:0005249		voltage-gated potassium channel activity
GO:0005509		calcium ion binding
GO:0005886		plasma membrane
GO:0005891		voltage-gated calcium channel complex
GO:0006811		ion transport
GO:0006813		potassium ion transport
GO:0006816		calcium ion transport
GO:0007268		synaptic transmission
GO:0008076		voltage-gated potassium channel complex
GO:0016020		membrane
GO:0016021		integral to membrane
GO:0042593		glucose homeostasis
GO:0043204		perikaryon
GO:0047485		protein N-terminus binding

Pathway

KEGG:

KEGG PATHWAY ID		Name
hsa04020		Calcium signaling pathway
hsa04010		MAPK signaling pathway
hsa04930		Type II diabetes mellitus

Panther:

ID		Description
P00039		Metabotropic glutamate receptor group III pathway
P04394		Thyrotropin-releasing hormone receptor signaling pathway
P00037		Ionotropic glutamate receptor pathway
P00040		Metabotropic glutamate receptor group II pathway
P00027		Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway

Chemicals

DrugBank:

Name

Synonyms

HMDB:

Name

Synonyms

Orthology

Orthology Relations:

Gene	Gene Description	Organism	Orthology type	Orthologs	Orthologs Description
ENSG00000198216	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878]	Pan_troglodytes	one2one	ENSPTRG00000001749	PREDICTED: Pan troglodytes similar to voltage-dependent calcium channel alpha-1E-3 (LOC457564), mRNA. [Source:RefSeq_dna;Acc:XR_024642][hgnc]LOC457564
		Pongo_pygmaeus	one2one	ENSPPYG00000000442	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Macaca_mulatta	one2one	ENSMMUG00000014498	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Tarsius_syrichta	one2one	ENSTSYG00000011774	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Tursiops_truncatus	one2one	ENSTTRG00000003504	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Equus_caballus	one2one	ENSECAG00000012027	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Tupaia_belangeri	one2one	ENSTBEG00000015583	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Microcebus_murinus	one2one	ENSMICG00000008818	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Felis_catus	one2one	ENSFCAG00000015444	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Cavia_porcellus	one2one	ENSCPOG00000014861	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Spermophilus_tridecemlineatus	one2one	ENSSTOG00000009320	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Otolemur_garnettii	one2one	ENSOGAG00000001113	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Procavia_capensis	one2one	ENSPCAG00000009916	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Dipodomys_ordii	one2one	ENSDORG00000001636	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q61290][hgnc]
		Pteropus_vampyrus	one2one	ENSPVAG00000004068	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Vicugna_pacos	one2one	ENSVPAG00000000697	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Mus_musculus	one2one	ENSMUSG00000004110	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q61290][hgnc]Cacna1e
		Rattus_norvegicus	one2one	ENSRNOG00000002863	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage- gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (RBE-II) (RBE2) (Brain calcium channel II) (BII). [Source:UniProtKB/Swiss-Prot;Acc:Q07652][hgnc]Cacna1e
		Myotis_lucifugus	one2one	ENSMLUG00000017464	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Echinops_telfairi	one2one	ENSETEG00000000110	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Erinaceus_europaeus	one2one	ENSEEUG00000003927	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Loxodonta_africana	one2one	ENSLAFG00000009241	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Ochotona_princeps	one2one	ENSOPRG00000005674	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Oryctolagus_cuniculus	one2one	ENSOCUG00000017547	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Ornithorhynchus_anatinus	one2one	ENSOANG00000000975	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Monodelphis_domestica	one2one	ENSMODG00000006729	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Gallus_gallus	one2one	ENSGALG00000003833	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Canis_familiaris	one2one	ENSCAFG00000013004	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Xenopus_tropicalis	one2one	ENSXETG00000012458	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Danio_rerio	apprent_one2one	ENSDARG00000062346	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]
		Oryzias_latipes	one2one	ENSORLG00000011019	Voltage-dependent R-type calcium channel subunit alpha-1E (Voltage-gated calcium channel subunit alpha Cav2.3) (Calcium channel, L type, alpha-1 polypeptide, isoform 6) (Brain calcium channel II) [Source:UniProtKB/Swiss-Prot;Acc:Q15878][hgnc]