Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Summary sheet information for GPCR 'LEUKOTRIENE RECEPTORS_BLT1_Homo sapiens'

Name

LEUKOTRIENE RECEPTORS_BLT1_Homo sapiens

Description

RecName: Full=Leukotriene B4 receptor 1; Short=LTB4-R 1;AltName: Full=P2Y purinoceptor 7; Short=P2Y7;AltName: Full=Chemoattractant receptor-like 1;AltName: Full=G-protein coupled receptor 16

Class

CLASS A

Family

LEUKOTRIENE RECEPTORS

Sub_family

BLT1

type

Protein features link

Protein Information from Dasty2 DAS Client

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level

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Genes

Gene Location:

Chromosome	: 14
Gene Start	: 23850545
Gene End	: 23857082
Ensembl Contig View

Ensembl Genes:

ENSG00000213903

EMBL:

EMBL ID		Description
AB008193		Homo sapiens genes for leukotriene B4 receptor BLT2, leukotriene B4 receptor BLT1, complete cds.
AY322535		Homo sapiens leukotriene B4 receptor gene, complete cds.
BC004545		Homo sapiens leukotriene B4 receptor, mRNA (cDNA clone MGC:10388 IMAGE:3946189), complete cds.
BT007267		Homo sapiens leukotriene B4 receptor mRNA, complete cds.
D89078		Homo sapiens mRNA for leukotriene b4 receptor, complete cds.
D89079		Homo sapiens mRNA for leukotriene b4 receptor, complete cds.
U33448		Human putative G-protein-coupled receptor (GPR16) gene, complete cds.
U41070		Human P2 purinergic receptor mRNA, complete cds.
X98356		H.sapiens mRNA for G protein-coupled receptor

EntrezGene:

ID		Description
LTB4R		leukotriene B4 receptor

RefSeq DNA:

ID		Description
NM_181657		Homo sapiens leukotriene B4 receptor (LTB4R), transcript variant 1, mRNA.

UniGene:

ID		Description
Hs.567248		Transcribed locus
Hs.655431		Leukotriene b4 receptor
Hs.679769		Transcribed locus, strongly similar to XP_001114016.1 PREDICTED: leukotriene B4 receptor isoform 1 [Macaca mulatta]

Proteins

Ensembl Proteins:

ENSP00000380002; ENSP00000307445; ENSP00000380008

Entrez Proteins:

AAB16747.1; AAC50628.1; AAH04545.1; AAP35931.1; AAP84348.1; BAA20423.1; BAA20424.1; BAB00611.1; CAA67001.1

RefSeq Proteins:

ID		Description
NP_858043		leukotriene B4 receptor [Homo sapiens].

UniProt:

ID		Description
Q53XV5		SubName: Full=Leukotriene B4 receptor;
Q15722		RecName: Full=Leukotriene B4 receptor 1; Short=LTB4-R 1; AltName: Full=P2Y purinoceptor 7; Short=P2Y7; AltName: Full=Chemoattractant receptor-like 1; AltName: Full=G-protein coupled receptor 16;

Domains

SMART:

- Hyperlink to SMART;

- Hyperlink to ENSEMBL

InterPro:

ID		Name
IPR000276		GPCR_Rhodpsn
IPR003983		LTB4_t1_rcpt
IPR017452		GPCR_Rhodpsn_supfam
IPR003981		LTB4_rcpt

Pfam:

ID		Description
7tm_1		7 transmembrane receptor (rhodopsin family)

Structure

PDB:

HSSP:

Description

PSSH:

ID		Description
Q53XV5		UNKNOWN
Q15722		UNKNOWN

Diseases

OMIM:

OMIM ID		Name		Alt Name
601531		LEUKOTRIENE B4 RECEPTOR; LTB4R		LTB4R1 CHEMOKINE RECEPTOR-LIKE 1; CMKRL1 PURINERGIC RECEPTOR P2Y, G PROTEIN-COUPLED, 7; P2RY7 PURINOCEPTOR P2Y7; P2Y7 LEUKOTRIENE B4 G PROTEIN-COUPLED RECEPTOR; BLTR BLT1 G PROTEIN-COUPLED RECEPTOR 16; GPR16

Gene Ontology

GO:

GO ID		Description
GO:0000166		nucleotide binding
GO:0001584		rhodopsin-like receptor activity
GO:0001632		leukotriene B4 receptor activity
GO:0004872		receptor activity
GO:0004945		angiotensin type II receptor activity
GO:0004966		galanin receptor activity
GO:0004974		leukotriene receptor activity
GO:0004982		N-formyl peptide receptor activity
GO:0005886		plasma membrane
GO:0005887		integral to plasma membrane
GO:0006928		cell motion
GO:0006936		muscle contraction
GO:0006954		inflammatory response
GO:0006955		immune response
GO:0007165		signal transduction
GO:0007186		G-protein coupled receptor protein signaling pathway
GO:0007200		activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
GO:0016021		integral to membrane
GO:0045028		purinergic nucleotide receptor activity, G-protein coupled

Pathway

KEGG:

KEGG PATHWAY ID		Name
hsa04080		Neuroactive ligand-receptor interaction

Panther:

Description

Chemicals

DrugBank:

Name

Synonyms

HMDB:

Name

Synonyms

Other GPCR resources

Links to other GPCR resources

GPCRDB | GPCR-OKB | GLIDA

Orthology

Orthology Relations:

Gene	Gene Description	Organism	Orthology type	Orthologs	Orthologs Description
ENSG00000213903	Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722]	Pan_troglodytes	one2one	ENSPTRG00000006215	Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722][hgnc]LTB4R
		Pongo_pygmaeus	one2one	ENSPPYG00000005701	Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722][hgnc]
		Macaca_mulatta	one2one	ENSMMUG00000020697	Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722][hgnc]
		Tarsius_syrichta	one2one	ENSTSYG00000014217	Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722][hgnc]
		Equus_caballus	one2one	ENSECAG00000004228	Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722][hgnc]LOC100051017
		Bos_taurus	one2one	ENSBTAG00000010238	Leukotriene B4 receptor 1 (LTB4-R 1). [Source:UniProtKB/Swiss-Prot;Acc:Q3T181][hgnc]LTB4R
		Rattus_norvegicus	one2one	ENSRNOG00000020399	Leukotriene B4 receptor 1 (LTB4-R 1). [Source:UniProtKB/Swiss-Prot;Acc:Q9R0Q2][hgnc]Ltb4r
		Mus_musculus	one2one	ENSMUSG00000046908	Leukotriene B4 receptor 1 (LTB4-R 1) [Source:UniProtKB/Swiss-Prot;Acc:O88855][hgnc]Ltb4r1
		Cavia_porcellus	one2one	ENSCPOG00000014410	LTB4 receptor (Leukotriene B4 receptor). [Source:UniProtKB/TrEMBL;Acc:Q9WTK1][hgnc]
		Monodelphis_domestica	one2one	ENSMODG00000003043	Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722][hgnc]
		Ornithorhynchus_anatinus	one2one	ENSOANG00000015073	Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16) [Source:UniProtKB/Swiss-Prot;Acc:Q15722][hgnc]100089776
		Xenopus_tropicalis	one2many	ENSXETG00000017222	Leukotriene B4 receptor 1 (LTB4-R 1) (P2Y purinoceptor 7) (P2Y7) (Chemoattractant receptor-like 1) (G-protein coupled receptor 16). [Source:UniProtKB/Swiss-Prot;Acc:Q15722] [from human gene ENSG00000168986][hgnc]
		Danio_rerio	many2many	ENSDARG00000032631	[hgnc]LOC566585
		Danio_rerio	many2many	ENSDARG00000061094	[hgnc]
		Oryzias_latipes	many2many	ENSORLG00000018941	[hgnc]
		Gasterosteus_aculeatus	many2many	ENSGACG00000018962	[hgnc]
		Gasterosteus_aculeatus	many2many	ENSGACG00000018954	[hgnc]
		Tetraodon_nigroviridis	many2many	ENSTNIG00000007431	[hgnc]
		Oryzias_latipes	many2many	ENSORLG00000018947	[hgnc]
		Gasterosteus_aculeatus	many2many	ENSGACG00000018963	[hgnc]
		Gasterosteus_aculeatus	many2many	ENSGACG00000017812	[hgnc]
		Tetraodon_nigroviridis	many2many	ENSTNIG00000007432	[hgnc]
		Danio_rerio	many2many	ENSDARG00000067922	[hgnc]LOC799131
		Danio_rerio	many2many	ENSDARG00000054170	[hgnc]LOC100007528
		Takifugu_rubripes	one2many	ENSTRUG00000006931	Leukotriene B4 receptor 2 (LTB4-R2) (Seven transmembrane receptor BLTR2) (Leukotriene B4 receptor BLT2) (LTB4 receptor JULF2) [Source:UniProtKB/Swiss-Prot;Acc:Q9NPC1][hgnc]
		Danio_rerio	many2many	ENSDARG00000053109	[hgnc]
		Oryzias_latipes	many2many	ENSORLG00000002957	[hgnc]