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Description Entry page for Effector - 'EBP50/NHERF 1-Homo sapiens'
FamilyEzrin-radixin-moesin-binding phosphoproteins
Sub-FamilyEzrin-radixin-moesin-binding phosphoproteins
TypeEBP50/NHERF 1
Cross References:
References
UniProtO14745 | O43552 | Q86WQ5
EMBLAF015926 | AF036241 | BC001443 | BC003361 | BC011777 | BC049220 | BC053350
InterProIPR015098 | IPR017300 | IPR001478
PRODOM
GENEID9368
MIM604990 | 612287
PRINTS
PFAMPF09007 | PF00595
Details:
Details
NameEBP50/NHERF 1-Homo sapiens
DescriptionRecName: Full=Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Short=NHERF-1;AltName: Full=Ezrin-radixin-moesin-binding phosphoprotein 50; Short=EBP50;AltName: Full=Regulatory cofactor of Na(+)/H(+) exchanger;AltName: Full=Sodium-hydrogen exchanger regulatory factor 1;AltName: Full=Solute carrier family 9 isoform A3 regulatory factor 1
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneSLC9A3R1 | NHERF,NHERF
FunctionScaffold protein that connects plasma membrane proteinss with members of the ezrin/moesin/radixin family and thereby helpss to link them to the actin cytoskeleton and to regulate theirs surface expression
Fragment0
Sequence
MSADAAAGAPLPRLCCLEKGPNGYGFHLHGEKGKLGQYIRLVEPGSPAEKAGLLAGDRLV
EVNGENVEKETHQQVVSRIRAALNAVRLLVVDPETDEQLQKLGVQVREELLRAQEAPGQA
EPPAAAEVQGAGNENEPREADKSHPEQRELRPRLCTMKKGPSGYGFNLHSDKSKPGQFIR
SVDPDSPAEASGLRAQDRIVEVNGVCMEGKQHGDVVSAIRAGGDETKLLVVDRETDEFFK
KCRVIPSQEHLNGPLPVPFTNGEIQKENSREALAEAALESPRPALVRSASSDTSEELNSQ
DSPPKQDSTAPSSTSSSDPILDFNISLAMAKERAHQKRSSKRAPQMDWSKKNELFSNL
Interacting with G-proteins:
G-proteins
NoNameRegulationPubMed
1Galpha-q_Homo sapiensInhibits PLC-beta activation and blocks Gqa-induce Tph and CXCR4 receptor internalization16182515
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level