Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Description

Entry page for Effector - 'GRK4-Homo sapiens'

Family	Ser Thr protein kinases
Sub-Family	G protein coupled receptor kinases
Type	GRK4

Cross References:

References

UniProt	P32298 \| O00641 \| O00642 \| Q13293 \| Q13294 \| Q13295 \| Q14453 \| Q14725
EMBL	L03718 \| X97879 \| X97880 \| X97881 \| U33054 \| U33055 \| U33056 \| U33168 \| U33153 \| U33155 \| U33156 \| U33157 \| U33158 \| U33159 \| U33160 \| U33161 \| U33162 \| U33163 \| U33164 \| U33165 \| U33166 \| U33167 \| U33168 \| U33153 \| U33154 \| U33155 \| U33156 \| U33157 \| U33158 \| U33159 \| U33160 \| U33161 \| U33162 \| U33163 \| U33164 \| U33165 \| U33166 \| U33167 \| U33168 \| U33153 \| U33154 \| U33155 \| U33156 \| U33157 \| U33158 \| U33159 \| U33160 \| U33161 \| U33162 \| U33163 \| U33164 \| U33165 \| U33166 \| U33168 \| U33153 \| U33155 \| U33156 \| U33157 \| U33158 \| U33159 \| U33160 \| U33161 \| U33162 \| U33163 \| U33164 \| U33165 \| U33166 \| AK223581 \| X98118 \| X75897 \| Z68192 \| BC117320
InterPro	IPR000961 \| IPR000239 \| IPR000719 \| IPR017441 \| IPR000342 \| IPR017442 \| IPR008271 \| IPR002290
PRODOM	PD000001
GENEID	2868
MIM	137026
PRINTS	PR00717
PFAM	PF00069 \| PF00615

Details:

Details

Name	GRK4-Homo sapiens
Description	RecName: Full=G protein-coupled receptor kinase 4; EC=2.7.11.16;AltName: Full=G protein-coupled receptor kinase GRK4;AltName: Full=ITI1
Species	Homo sapiens
Common Name	Human
NCBI Taxonomy	9606
Gene	GRK4 \| GPRK2L,GPRK
Function	Specifically phosphorylates the activated forms of Gs protein-coupled receptors
Fragment	0
Sequence	MELENIVANSLLLKARQGGYGKKSGRSKKWKEILTLPPVSQCSELRHSIEKDYSSLCDKQ PIGRRLFRQFCDTKPTLKRHIEFLDAVAEYEVADDEDRSDCGLSILDRFFNDKLAAPLPE IPPDVVTECRLGLKEENPSKKAFEECTRVAHNYLRGEPFEEYQESSYFSQFLQWKWLERQ PVTKNTFRHYRVLGKGGFGEVCACQVRATGKMYACKKLQKKRIKKRKGEAMALNEKRILE KVQSRFVVSLAYAYETKDALCLVLTIMNGGDLKFHIYNLGNPGFDEQRAVFYAAELCCGL EDLQRERIVYRDLKPENILLDDRGHIRISDLGLATEIPEGQRVRGRVGTVGYMAPEVVNN EKYTFSPDWWGLGCLIYEMIQGHSPFKKYKEKVKWEEVDQRIKNDTEEYSEKFSEDAKSI CRMLLTKNPSKRLGCRGEGAAGVKQHPVFKDINFRRLEANMLEPPFCPDPHAVYCKDVLD IEQFSVVKGIYLDTADEDFYARFATGCVSIPWQNEMIESGCFKDINKSESEEALPLDLDK NIHTPVSRPNRGFFYRLFRRGGCLTMVPSEKEVEPKQC

Interacting with G-proteins:

G-proteins

No	Name	Regulation	PubMed
1	Galpha-11_Homo sapiens	Stimulation	15251227 \| 14654303

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level