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Description Entry page for GPCR - 'OREXIN RECEPTORS_OX1_Homo sapiens'
ClassCLASS A
FamilyOREXIN RECEPTORS
Sub-FamilyOX1
Cross References:
References
UniProtO43613 | A8K3A6 | Q9HBV6
EMBLAF041243 | AF202084 | AF202078 | AF202079 | AF202080 | AF202081 | AF202082 | AF202083 | AY062030 | AY070269 | AK290521 | AC114488 | CH471059 | BC074796
InterProIPR000276 | IPR017452 | IPR000204 | IPR004059
PRODOM
GENEID3061
MIM602392
PRINTSPR00237 | PR01521 | PR01064
PFAMPF00001
Other GPCR resourcesGPCRDB | GPCR-OKB | GLIDA
Details:
Details
NameOREXIN RECEPTORS_OX1_Homo sapiens
DescriptionRecName: Full=Orexin receptor type 1;AltName: Full=Ox1r;AltName: Full=Hypocretin receptor type 1
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneHCRTR
FunctionModerately selective excitatory receptor for orexin-As and, with a lower affinity, for orexin-B neuropeptide
Fragment0
Sequence
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVA
LVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCK
VIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQA
AVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFR
KLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKML
MVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNF
LSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSV
TTVLP
Interacting with G-proteins:
G-proteins
NoNameCouplingPubMed
1Galpha-11_Homo sapiensGq/119491897
2Galpha-14_Homo sapiensGq/119491897
3Galpha-q_Homo sapiensGq/119491897
4Galpha-15_Homo sapiensGq/119491897
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level