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Summary sheet information for GPCR 'CALCITONIN RECEPTORS_CGRP_Homo sapiens'
Name CALCITONIN RECEPTORS_CGRP_Homo sapiens
Description RecName: Full=Calcitonin gene-related peptide type 1 receptor; Short=CGRP type 1 receptor;AltName: Full=Calcitonin receptor-like receptor;Flags: Precursor
Class CLASS B
Family CALCITONIN RECEPTORS
Sub_family CGRP
type
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 2
Gene Start: 187916099
Gene End: 188021266
Ensembl Contig View
Ensembl Genes:
ENSG00000064989
EMBL:
EMBL ID  Description
AC007319  Homo sapiens BAC clone RP11-432D12 from 2, complete sequence.
AC074020  Homo sapiens BAC clone RP11-341A4 from 2, complete sequence.
AK291630  Homo sapiens cDNA FLJ78076 complete cds, highly similar to Homo sapiens calcitonin receptor-like (CALCRL), mRNA.
AK292998  Homo sapiens cDNA FLJ75294 complete cds, highly similar to Human calcitonin-like receptor mRNA.
AY389506  Homo sapiens calcitonin receptor-like protein (CALCRL) mRNA, complete cds.
L76380  Homo sapiens (clone HSNME29) CGRP type 1 receptor mRNA, complete cds.
U17473  Human calcitonin-like receptor mRNA, complete cds.

EntrezGene:
ID  Description
CALCRL  calcitonin receptor-like
RefSeq DNA:
ID  Description
NM_005795  Homo sapiens calcitonin receptor-like (CALCRL), mRNA.

UniGene:
ID  Description
Hs.470882  CDNA FLJ78076 complete cds, highly similar to Homo sapiens calcitonin receptor-like (CALCRL), mRNA

Proteins
Ensembl Proteins:
ENSP00000376177
Entrez Proteins:
AAA62158.1; AAC41994.1; AAQ91332.1; AAY14806.1; AAY14996.1; BAF84319.1; BAF85687.1
RefSeq Proteins:
ID  Description
NP_005786  calcitonin receptor-like [Homo sapiens].

UniProt:
ID  Description
A8K6G5  SubName: Full=cDNA FLJ78076, highly similar to Homo sapiens calcitonin receptor-like (CALCRL), mRNA;
A8KAD3  UNKNOWN
Q53S02  SubName: Full=Putative uncharacterized protein CALCRL; Flags: Fragment;
Q53TS5  SubName: Full=Putative uncharacterized protein CALCRL; Flags: Fragment;
Q16602  RecName: Full=Calcitonin gene-related peptide type 1 receptor; Short=CGRP type 1 receptor; AltName: Full=Calcitonin receptor-like receptor; Flags: Precursor;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR017981  GPCR_2-like
IPR003289  GPCR_2_CGRP1_rcpt
IPR000832  GPCR_2_secretin-like
IPR017983  GPCR_2_secretin-like_CS
IPR003287  GCPR_2_calcitonin_rcpt-like
IPR001879  GPCR_2_extracellular
Pfam:
ID  Description
7tm_2  7 transmembrane receptor (Secretin family)
HRM  Hormone receptor domain

Structure
PDB:
ID
HSSP:
ID  Description
2qkh  SIGNALING PROTEIN/HORMONE
3c4m  MEMBRANE PROTEIN
PSSH:
ID  Description
Q53TS5  UNKNOWN
Q16602  UNKNOWN
Diseases
OMIM:
OMIM ID  Name  Alt Name
114190  CALCITONIN RECEPTOR-LIKE GENE; CALCRL   CALCITONIN RECEPTOR-LIKE RECEPTOR; CRLR CALCITONIN GENE-RELATED PEPTIDE RECEPTOR; CGRPR
Gene Ontology
GO:
GO ID  Description
GO:0001635  calcitonin gene-related polypeptide receptor activity
GO:0004872  receptor activity
GO:0004930  G-protein coupled receptor activity
GO:0004948  calcitonin receptor activity
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007187  G-protein signaling, coupled to cyclic nucleotide second messenger
GO:0007189  activation of adenylate cyclase activity by G-protein signaling pathway
GO:0007507  heart development
GO:0008284  positive regulation of cell proliferation
GO:0016020  membrane
GO:0048661  positive regulation of smooth muscle cell proliferation
Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04080  Neuroactive ligand-receptor interaction
hsa04270  Vascular smooth muscle contraction

Panther:
ID  Description
Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Other GPCR resources
Links to other GPCR resources
GPCRDB | GPCR-OKB | GLIDA
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000064989 Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602] Monodelphis_domesticaone2one ENSMODG00000010687Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000013009Putative uncharacterized protein DKFZp469G2011. [Source:UniProtKB/TrEMBL;Acc:Q5RCU8][hgnc]
Macaca_mulattaone2one ENSMMUG00000009447Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Pan_troglodytesone2one ENSPTRG00000012722Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]CALCRL
Canis_familiarisone2one ENSCAFG00000014737Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]CALCRL
Oryctolagus_cuniculusone2one ENSOCUG00000013954Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Echinops_telfairione2one ENSETEG00000010646Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Dipodomys_ordiione2one ENSDORG00000015372Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q9R1W5][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000012406Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Sorex_araneusone2one ENSSARG00000014497Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Otolemur_garnettiione2one ENSOGAG00000004394Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Loxodonta_africanaone2one ENSLAFG00000004231Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Tupaia_belangerione2one ENSTBEG00000006089Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Ochotona_princepsone2one ENSOPRG00000000724Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Felis_catusone2one ENSFCAG00000010307Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000003697Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Tursiops_truncatusone2one ENSTTRG00000013820Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Vicugna_pacosone2one ENSVPAG00000005616Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Bos_taurusone2one ENSBTAG00000008483MGC155061 protein. [Source:UniProtKB/TrEMBL;Acc:A6QP74][hgnc]CALCRL
Equus_caballusone2one ENSECAG00000012990Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]LOC100054281
Microcebus_murinusone2one ENSMICG00000001266Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000002764Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000007881Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Cavia_porcellusone2one ENSCPOG00000001012Calcitonin receptor-like receptor (Fragment). [Source:UniProtKB/TrEMBL;Acc:O88976][hgnc]
Rattus_norvegicusone2one ENSRNOG00000004622Calcitonin gene-related peptide type 1 receptor precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor). [Source:UniProtKB/Swiss-Prot;Acc:Q63118][hgnc]Calcrl
Erinaceus_europaeusone2one ENSEEUG00000005289Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Procavia_capensisone2one ENSPCAG00000000909Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Mus_musculusone2one ENSMUSG00000059588Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q9R1W5][hgnc]Calcrl
Myotis_lucifugusone2one ENSMLUG00000014787Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Gallus_gallusone2one ENSGALG00000002632Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]CALCRL
Xenopus_tropicalisone2one ENSXETG00000013895[hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000020803Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Takifugu_rubripesone2many ENSTRUG00000006816Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000002387Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000008869Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Danio_rerioone2many ENSDARG00000011473hypothetical protein LOC445508 [Source:RefSeq_peptide;Acc:NP_001004010][hgnc]zgc:100872
Oryzias_latipesone2many ENSORLG00000014452Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Danio_rerioone2many ENSDARG00000011571[hgnc]LOC100006513
Gasterosteus_aculeatusone2many ENSGACG00000014916Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Oryzias_latipesone2many ENSORLG00000000091Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Takifugu_rubripesone2many ENSTRUG00000011835Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Tetraodon_nigroviridisone2many ENSTNIG00000010610Calcitonin gene-related peptide type 1 receptor Precursor (CGRP type 1 receptor) (Calcitonin receptor-like receptor) [Source:UniProtKB/Swiss-Prot;Acc:Q16602][hgnc]
Aedes_aegyptione2many AAEL010043calcitonin receptor[hgnc]