Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Summary sheet information for G-protein 'Galpha-t1_Homo sapiens'

Name

Galpha-t1_Homo sapiens

Description

RecName: Full=Guanine nucleotide-binding protein G(t) subunit alpha-1;AltName: Full=Transducin alpha-1 chain

Class

Galpha

Family

Gi/o

Sub_family

Galpha-t

type

Galpha-t1

Protein features link

Protein Information from Dasty2 DAS Client

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level

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Genes

Gene Location:

Chromosome	: 3
Gene Start	: 50204047
Gene End	: 50208953
Ensembl Contig View

Ensembl Genes:

ENSG00000114349

EMBL:

EMBL ID		Description
AC002077		Human cosmid clone LUCA17 from 3p21.3, complete sequence.
AF493908		Homo sapiens guanine nucleotide binding protein alpha transducin rod (GNATR) mRNA, complete cds.
BC095505		Homo sapiens guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1, mRNA (cDNA clone MGC:111716 IMAGE:6519160), complete cds.
X15088		Human GNAT1 mRNA for transducin alpha-chain
X63749		H.sapiens DNA for Rod transducin alpha-subunit

EntrezGene:

ID		Description
GNAT1		guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1

RefSeq DNA:

ID		Description
NM_000172		Homo sapiens guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 (GNAT1), transcript variant 2, mRNA.
NM_144499		Homo sapiens guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 (GNAT1), transcript variant 1, mRNA.

UniGene:

ID		Description
Hs.517978		GNAT1 mRNA for transducin alpha-chain

Proteins

Ensembl Proteins:

ENSP00000384624; ENSP00000232461

Entrez Proteins:

AAB54048.1; AAH95505.1; AAM12622.1; CAA33196.1; CAB37839.2

RefSeq Proteins:

ID		Description
NP_000163		guanine nucleotide binding protein, alpha transducing activity polypeptide 1 [Homo sapiens].
NP_653082		guanine nucleotide binding protein, alpha transducing activity polypeptide 1 [Homo sapiens].

UniProt:

ID		Description
P11488		RecName: Full=Guanine nucleotide-binding protein G(t) subunit alpha-1; AltName: Full=Transducin alpha-1 chain;

Domains

SMART:

- Hyperlink to SMART;

- Hyperlink to ENSEMBL

InterPro:

ID		Name
IPR001408		Gprotein_alpha_I
IPR001019		Gprotein_alph_bd

Pfam:

ID		Description
G-alpha		G-protein alpha subunit

Structure

PDB:

HSSP:

ID		Description
1agr		COMPLEX (SIGNAL TRANSDUCTION/REGULATOR)
1as0		SIGNAL TRANSDUCTION
1as2		SIGNAL TRANSDUCTION
1as3		SIGNAL TRANSDUCTION
1azs		COMPLEX (LYASE/HYDROLASE)
1azt		HYDROLASE
1bh2		SIGNAL TRANSDUCTION PROTEIN
1bof		SIGNAL TRANSDUCTION PROTEIN
1cip		HYDROLASE
1cjk		LYASE/LYASE/SIGNALING PROTEIN
1cjt		LYASE/LYASE/SIGNALING PROTEIN
1cju		LYASE/LYASE/SIGNALING PROTEIN
1cjv		LYASE/LYASE/SIGNALING PROTEIN
1cs4		LYASE/LYASE/SIGNALING PROTEIN
1cul		LYASE/LYASE/SIGNALING PROTEIN
1fqj		SIGNALING PROTEIN
1fqk		SIGNALING PROTEIN
1gdd		SIGNAL TRANSDUCTION PROTEIN
1gfi		SIGNAL TRANSDUCTION PROTEIN
1gg2		COMPLEX (GTP-BINDING/TRANSDUCER)
1gia		SIGNAL TRANSDUCTION PROTEIN
1gil		GTP-BINDING PROTEIN
1git		GTP-BINDING PROTEIN
1got		COMPLEX (GTP-BINDING/TRANSDUCER)
1gp2		COMPLEX (GTP-BINDING/TRANSDUCER)
1kjy		SIGNALING PROTEIN
1shz		SIGNALING PROTEIN
1svk		HYDROLASE, SIGNALING PROTEIN
1svs		HYDROLASE, SIGNALING PROTEIN
1tad		GTP-BINDING PROTEIN
1tag		GTP-BINDING PROTEIN
1tl7		LYASE
1tnd		BINDING PROTEIN(GTP)
1u0h		LYASE
1y3a		SIGNALING PROTEIN
1zca		SIGNALING PROTEIN
1zcb		SIGNALING PROTEIN
2bcj		TRANSFERASE/HYDROLASE
2ebc		SIGNALING PROTEIN
2g83		SIGNALING PROTEIN
2gtp		SIGNALING PROTEIN
2gvd		LYASE
2gvz		LYASE
2hlb		SIGNALING PROTEIN
2ihb		SIGNALING PROTEIN
2ik8		SIGNALING PROTEIN
2ode		SIGNALING PROTEIN
2om2		SIGNALING PROTEIN
2pz2		HYDROLASE
2pz3		HYDROLASE
2rgn		SIGNALING PROTEIN COMPLEX
2v4z		CELL CYCLE
3c14		LYASE/LYASE INHIBITOR
3c15		LYASE/LYASE INHIBITOR
3c16		LYASE/LYASE INHIBITOR
3c7k		SIGNALING PROTEIN
3cx6		SIGNALING PROTEIN
3cx7		SIGNALING PROTEIN
3cx8		SIGNALING PROTEIN

PSSH:

ID		Description
P11488		UNKNOWN

Diseases

OMIM:

OMIM ID		Name		Alt Name
139330		GUANINE NUCLEOTIDE-BINDING PROTEIN, ALPHA-TRANSDUCING ACTIVITY POLYPEPTIDE 1; GNAT1		G PROTEIN, ALPHA-TRANSDUCING 1 TRANSDUCIN, ROD-SPECIFIC, ALPHA POLYPEPTIDE

Gene Ontology

GO:

GO ID		Description
GO:0000166		nucleotide binding
GO:0004871		signal transducer activity
GO:0005525		GTP binding
GO:0007165		signal transduction
GO:0007186		G-protein coupled receptor protein signaling pathway
GO:0007264		small GTPase mediated signal transduction
GO:0007601		visual perception
GO:0007602		phototransduction
GO:0008283		cell proliferation
GO:0019001		guanyl nucleotide binding
GO:0050896		response to stimulus

Pathway

KEGG:

KEGG PATHWAY ID

Name

Panther:

ID		Description
P00048		PI3 kinase pathway
P00028		Heterotrimeric G-protein signaling pathway-rod outer segment phototransduction

Chemicals

DrugBank:

Name

Synonyms

HMDB:

Name

Synonyms

Orthology

Orthology Relations:

Gene	Gene Description	Organism	Orthology type	Orthologs	Orthologs Description
ENSG00000114349	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488]	Caenorhabditis_elegans	many2many	T07A9.7	gpa-4 encodes a member of the G protein alpha subunit family of heterotrimeric GTPases. it is expressed in ASI. [Source: WormBase][hgnc]gpa-4
		Caenorhabditis_elegans	many2many	Y95B8A.5	gpa-16 (also known as spn-1) encodes a member of the G protein alpha subunit family of heterotrimeric GTPases that affects spindle position and orientation in embryos. it is expressed in AVM, PDE, PLM, BDU, PVC, and RIP, and weakly expressed in the pharynx, body-wall muscle, and vulval muscle. [Source: WormBase][hgnc]G-protein
		Pan_troglodytes	one2one	ENSPTRG00000014949	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]GNAT1
		Pongo_pygmaeus	one2one	ENSPPYG00000013853	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Macaca_mulatta	one2one	ENSMMUG00000010339	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Equus_caballus	one2one	ENSECAG00000018589	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]LOC100062183
		Tursiops_truncatus	one2one	ENSTTRG00000007722	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Pteropus_vampyrus	one2one	ENSPVAG00000017089	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Canis_familiaris	one2one	ENSCAFG00000010764	Guanine nucleotide-binding protein G(t), alpha-1 subunit (Transducin alpha-1 chain). [Source:UniProtKB/Swiss-Prot;Acc:Q28300][hgnc]GNAT1
		Bos_taurus	one2one	ENSBTAG00000018020	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain). [Source:UniProtKB/Swiss-Prot;Acc:P04695][hgnc]GNAT1
		Cavia_porcellus	one2one	ENSCPOG00000008168	Alpha-transducin. [Source:UniProtKB/TrEMBL;Acc:A9LS49][hgnc]
		Erinaceus_europaeus	one2one	ENSEEUG00000001885	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Felis_catus	one2one	ENSFCAG00000007006	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Tupaia_belangeri	one2one	ENSTBEG00000012902	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Myotis_lucifugus	one2one	ENSMLUG00000002053	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Oryctolagus_cuniculus	one2one	ENSOCUG00000011681	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Sorex_araneus	one2one	ENSSARG00000008774	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Microcebus_murinus	one2one	ENSMICG00000016240	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Procavia_capensis	one2one	ENSPCAG00000005787	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Ochotona_princeps	one2one	ENSOPRG00000015253	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Otolemur_garnettii	one2one	ENSOGAG00000012515	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Dipodomys_ordii	one2one	ENSDORG00000000373	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P20612][hgnc]
		Dasypus_novemcinctus	one2one	ENSDNOG00000013406	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Loxodonta_africana	one2one	ENSLAFG00000006239	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Mus_musculus	one2one	ENSMUSG00000034837	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P20612][hgnc]Gnat1
		Rattus_norvegicus	one2one	ENSRNOG00000017589	guanine nucleotide binding protein, alpha transducing 1 [Source:RefSeq_peptide;Acc:NP_001102250][hgnc]Gnat1_predicted
		Spermophilus_tridecemlineatus	one2one	ENSSTOG00000016186	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Monodelphis_domestica	one2one	ENSMODG00000012279	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Tetraodon_nigroviridis	one2one	ENSTNIG00000014749	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Danio_rerio	one2one	ENSDARG00000044199	guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 1 [Source:RefSeq_peptide;Acc:NP_571943][hgnc]gnat1
		Takifugu_rubripes	one2one	ENSTRUG00000011180	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Xenopus_tropicalis	one2one	ENSXETG00000007315	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Oryzias_latipes	one2one	ENSORLG00000018998	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Gasterosteus_aculeatus	one2one	ENSGACG00000012301	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]
		Ornithorhynchus_anatinus	one2one	ENSOANG00000005463	Guanine nucleotide-binding protein G(t) subunit alpha-1 (Transducin alpha-1 chain) [Source:UniProtKB/Swiss-Prot;Acc:P11488][hgnc]100077091
		Anopheles_gambiae	one2many	AGAP005904	G(Alpha)i. [Source:UniProtKB/TrEMBL;Acc:A0EJE8][hgnc]AgaP_ENSANGG00000011071
		Aedes_aegypti	many2many	AAEL009037	GTP-binding protein (i) alpha subunit, gnai[hgnc]
		Aedes_aegypti	many2many	AAEL011168	GTP-binding protein (i) alpha subunit, gnai[hgnc]
		Drosophila_melanogaster	one2many	FBgn0001104	[hgnc]G-ialpha65A
		Ciona_savignyi	one2many	ENSCSAVG00000001800	[hgnc]
		Ciona_intestinalis	one2many	ENSCING00000005305	G protein alpha subunit Gi splicing variant CiGi1a [Source:RefSeq_peptide;Acc:NP_001027619][hgnc]445618