Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Summary sheet information for GPCR 'OPSIN/RHODOPSIN RECEPTORS_OPN5_Homo sapiens'

Name

OPSIN/RHODOPSIN RECEPTORS_OPN5_Homo sapiens

Description

RecName: Full=Opsin-5;AltName: Full=Neuropsin;AltName: Full=G-protein coupled receptor 136;AltName: Full=G-protein coupled receptor PGR12;AltName: Full=Transmembrane protein 13

Class

CLASS A

Family

OPSIN/RHODOPSIN RECEPTORS

Sub_family

OPN5

type

Protein features link

Protein Information from Dasty2 DAS Client

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level

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Genes

Gene Location:

Chromosome	: 6
Gene Start	: 47857757
Gene End	: 47902073
Ensembl Contig View

Ensembl Genes:

ENSG00000124818

EMBL:

EMBL ID		Description
AL161622		Human DNA sequence from clone RP3-402H5 on chromosome 6p12.3-21.1 Contains the 3' end of a gene for a novel protein similar to seven transmembrane receptor (Rhodopsin family).
AL356421		Human DNA sequence from clone RP11-550C4 on chromosome 6 Contains the 3' end of the CD2AP gene for CD2-associated protein, the GPR111 gene for G protein-coupled receptor 111, the GPR115 gene for G protein-coupled receptor 115, the 5' end of a gene for novel protein similar to seven transmembrane receptor (Rhodopsin family), a novel gene and a ribosomal protein 27A (RPL27A) pseudogene.
AY255615		Homo sapiens G protein-coupled receptor PGR12 mRNA, partial cds.
AY288419		Homo sapiens G protein-coupled receptor 136 (GPR136) mRNA, complete cds.
AY377391		Homo sapiens neuropsin (OPN5) mRNA, complete cds.
BC126194		Homo sapiens opsin 5, mRNA (cDNA clone MGC:161472 IMAGE:8991910), complete cds.
BC126198		Homo sapiens opsin 5, mRNA (cDNA clone MGC:161476 IMAGE:8991914), complete cds.

EntrezGene:

ID		Description
OPN5		opsin 5

RefSeq DNA:

ID		Description
NM_001030051		Homo sapiens opsin 5 (OPN5), transcript variant 2, mRNA.
NM_181744		Homo sapiens opsin 5 (OPN5), transcript variant 1, mRNA.

UniGene:

Description

Proteins

Ensembl Proteins:

ENSP00000360255; ENSP00000377299; ENSP00000377302; ENSP00000244799

Entrez Proteins:

AAI26195.1; AAI26199.1; AAO85127.1; AAP72128.1; AAR21109.1; CAI20454.1

RefSeq Proteins:

ID		Description
NP_001025222		opsin 5 isoform 2 [Homo sapiens].
NP_859528		opsin 5 isoform 1 [Homo sapiens].

UniProt:

ID		Description
A8MVV5		SubName: Full=Putative uncharacterized protein OPN5;
Q6U736		RecName: Full=Opsin-5; AltName: Full=Neuropsin; AltName: Full=G-protein coupled receptor 136; AltName: Full=G-protein coupled receptor PGR12; AltName: Full=Transmembrane protein 13;

Domains

SMART:

- Hyperlink to SMART;

- Hyperlink to ENSEMBL

InterPro:

ID		Name
IPR000276		GPCR_Rhodpsn
IPR002962		Peropsin
IPR017452		GPCR_Rhodpsn_supfam
IPR001760		Opsin

Pfam:

ID		Description
7tm_1		7 transmembrane receptor (rhodopsin family)

Structure

PDB:

HSSP:

ID		Description
2z73		MEMBRANE PROTEIN
2ziy		SIGNALING PROTEIN

PSSH:

ID		Description
Q6U736		UNKNOWN

Diseases

OMIM:

OMIM ID		Name		Alt Name
609042		OPSIN 5; OPN5		NEUROPSIN G PROTEIN-COUPLED RECEPTOR 136; GPR136 PGR12

Gene Ontology

GO:

GO ID		Description
GO:0001584		rhodopsin-like receptor activity
GO:0007165		signal transduction
GO:0007186		G-protein coupled receptor protein signaling pathway
GO:0007601		visual perception
GO:0007602		phototransduction
GO:0009881		photoreceptor activity
GO:0016020		membrane
GO:0016021		integral to membrane
GO:0018298		protein-chromophore linkage
GO:0050896		response to stimulus

Pathway

KEGG:

KEGG PATHWAY ID

Name

Panther:

Description

Chemicals

DrugBank:

Name

Synonyms

HMDB:

Name

Synonyms

Other GPCR resources

Links to other GPCR resources

GPCRDB | GPCR-OKB | GLIDA

Orthology

Orthology Relations:

Gene	Gene Description	Organism	Orthology type	Orthologs	Orthologs Description
ENSG00000124818	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736]	Pan_troglodytes	one2one	ENSPTRG00000018249	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]OPN5
		Pongo_pygmaeus	one2one	ENSPPYG00000016680	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Macaca_mulatta	one2one	ENSMMUG00000013751	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Tarsius_syrichta	one2one	ENSTSYG00000005962	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Microcebus_murinus	one2one	ENSMICG00000015348	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Otolemur_garnettii	one2one	ENSOGAG00000002058	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Felis_catus	one2one	ENSFCAG00000015313	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Canis_familiaris	one2one	ENSCAFG00000002097	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]OPN5
		Equus_caballus	one2one	ENSECAG00000024718	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]LOC100055886
		Tupaia_belangeri	one2one	ENSTBEG00000001769	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Dasypus_novemcinctus	one2one	ENSDNOG00000005328	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Pteropus_vampyrus	one2one	ENSPVAG00000012641	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Bos_taurus	one2one	ENSBTAG00000016499	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]OPN5
		Loxodonta_africana	one2one	ENSLAFG00000016762	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Tursiops_truncatus	one2one	ENSTTRG00000004153	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Sorex_araneus	one2one	ENSSARG00000012550	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Erinaceus_europaeus	one2one	ENSEEUG00000005466	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Spermophilus_tridecemlineatus	one2one	ENSSTOG00000002889	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Myotis_lucifugus	one2one	ENSMLUG00000002878	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Echinops_telfairi	one2one	ENSETEG00000017780	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Procavia_capensis	one2one	ENSPCAG00000008526	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Vicugna_pacos	one2one	ENSVPAG00000003637	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Oryctolagus_cuniculus	one2one	ENSOCUG00000009406	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Ochotona_princeps	one2one	ENSOPRG00000011477	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Mus_musculus	one2one	ENSMUSG00000043972	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) [Source:UniProtKB/Swiss-Prot;Acc:Q6VZZ7][hgnc]Opn5
		Dipodomys_ordii	one2one	ENSDORG00000007833	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) [Source:UniProtKB/Swiss-Prot;Acc:Q6VZZ7][hgnc]
		Rattus_norvegicus	one2one	ENSRNOG00000012689	opsin 5 [Source:RefSeq_peptide;Acc:NP_861437][hgnc]Opn5
		Cavia_porcellus	one2one	ENSCPOG00000005742	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Monodelphis_domestica	one2one	ENSMODG00000018859	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Ornithorhynchus_anatinus	one2one	ENSOANG00000008281	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]100081156
		Gallus_gallus	one2one	ENSGALG00000016725	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]OPN5
		Xenopus_tropicalis	one2one	ENSXETG00000011322	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Danio_rerio	one2many	ENSDARG00000070110	Novel protein similar to vertebrate opsin 5 (OPN5) (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q5RIV6][hgnc]si:ch211-105n9.2
		Danio_rerio	one2many	ENSDARG00000014094	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Takifugu_rubripes	one2one	ENSTRUG00000017309	G protein-coupled receptor 136 (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q7T2L3][hgnc]
		Tetraodon_nigroviridis	one2many	ENSTNIG00000019183	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Tetraodon_nigroviridis	one2many	ENSTNIG00000019182	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Gasterosteus_aculeatus	one2one	ENSGACG00000004253	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]
		Oryzias_latipes	one2one	ENSORLG00000015647	Opsin-5 (Neuropsin) (G-protein coupled receptor 136) (G-protein coupled receptor PGR12) (Transmembrane protein 13) [Source:UniProtKB/Swiss-Prot;Acc:Q6U736][hgnc]