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Summary sheet information for Effector 'Ras GAP 2-Homo sapiens'
Name Ras GAP 2-Homo sapiens
Description RecName: Full=Ras GTPase-activating protein 2;AltName: Full=GAP1m
Class
Family GTPase activating proteins
Sub_family Ras GAPs
type Ras GAP 2
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 3
Gene Start: 142688581
Gene End: 142814311
Ensembl Contig View
Ensembl Genes:
ENSG00000155903
EMBL:
EMBL ID  Description
AB209161  Homo sapiens mRNA for RAS p21 protein activator 2 variant protein.
AF115573  Homo sapiens GTPase-activating protein GAP1m mRNA, complete cds.
AK292016  Homo sapiens cDNA FLJ76675 complete cds, highly similar to Homo sapiens RAS p21 protein activator 2 (RASA2), mRNA.
D78155  Homo sapiens mRNA for rasGTPase activating protein, complete cds.
D78156  Homo sapiens rasGAP gene for rasGTPase activating protein, partial cds.
D82880  Homo sapiens brain mRNA for Homo sapiens ras GTPase-activating protein,Gap1m, complete cds.
D82881  Homo sapiens genomic sequence for ras GTPase-activating protein, Gaplm, partial cds.

EntrezGene:
ID  Description
RASA2  RAS p21 protein activator 2
RefSeq DNA:
ID  Description
NM_006506  Homo sapiens RAS p21 protein activator 2 (RASA2), mRNA.

UniGene:
ID  Description
Hs.601431  Transcribed locus
Hs.655941  RasGTPase activating protein

Proteins
Ensembl Proteins:
ENSP00000286364
Entrez Proteins:
AAD09821.1; BAA11230.1; BAA11231.1; BAA11621.1; BAA11622.1; BAD92398.1; BAF84705.1
RefSeq Proteins:
ID  Description
NP_006497  RAS p21 protein activator 2 [Homo sapiens].

UniProt:
ID  Description
A8K7K1  SubName: Full=cDNA FLJ76675, highly similar to Homo sapiens RAS p21 protein activator 2 (RASA2), mRNA;
Q59GE8  SubName: Full=RAS p21 protein activator 2 variant; Flags: Fragment;
Q15283  RecName: Full=Ras GTPase-activating protein 2; AltName: Full=GAP1m;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Ras GAP 2-Homo sapiens    

InterPro:
ID  Name
IPR001936  RasGAP
IPR001849  Pleckstrin_homology
IPR000008  C2_Ca-dep
IPR018029  C2_membr_targeting
IPR011993  PH_type
IPR001562  Znf_Btk_motif
Pfam:
ID  Description
C2  C2 domain
PH  PH domain
RasGAP  GTPase-activator protein for Ras-like GTPase
BTK  BTK motif

Structure
PDB:
ID
HSSP:
ID  Description
1b55  TRANSFERASE
1btk  TRANSFERASE
1bwn  TRANSFERASE
1byn  ENDOCYTOSIS/EXOCYTOSIS
1eaz  LIPID DEGRADATION
1fao  SIGNALING PROTEIN
1fb8  SIGNALING PROTEIN
1nf1  SIGNALING PROTEIN
1rsy  CALCIUM/PHOSPHOLIPID BINDING PROTEIN
2nsq  LIGASE
2z0p  SIGNALING PROTEIN
3bxj  SIGNALING PROTEIN
3fbk  SIGNALING PROTEIN
PSSH:
ID  Description
Q59GE8  UNKNOWN
Q15283  UNKNOWN
Diseases
OMIM:
OMIM ID  Name  Alt Name
601589  RAS p21 PROTEIN ACTIVATOR 2; RASA2   GTPase-ACTIVATING PROTEIN OF RAS; GAP1M
Gene Ontology
GO:
GO ID  Description
GO:0005096  GTPase activator activity
GO:0005099  Ras GTPase activator activity
GO:0005622  intracellular
GO:0005737  cytoplasm
GO:0007165  signal transduction
GO:0007242  intracellular signaling cascade
GO:0008270  zinc ion binding
GO:0042309  homoiothermy
GO:0046872  metal ion binding
GO:0050825  ice binding
GO:0050826  response to freezing
GO:0051056  regulation of small GTPase mediated signal transduction
Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04010  MAPK signaling pathway

Panther:
ID  Description
P00047  PDGF signaling pathway
P00018  EGF receptor signaling pathway
P00021  FGF signaling pathway
Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000155903 Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283] Pan_troglodytesone2one ENSPTRG00000015472Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]RASA2
Pongo_pygmaeusone2one ENSPPYG00000014165Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Macaca_mulattaone2one ENSMMUG00000009418Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Microcebus_murinusone2one ENSMICG00000001345Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Equus_caballusone2one ENSECAG00000010845Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]LOC100063323
Felis_catusone2one ENSFCAG00000002561Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000002387Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Canis_familiarisone2one ENSCAFG00000007674Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]RASA2
Tursiops_truncatusone2one ENSTTRG00000012030Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000008023Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Myotis_lucifugusone2one ENSMLUG00000007834Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Vicugna_pacosone2one ENSVPAG00000004682Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Otolemur_garnettiione2one ENSOGAG00000002470Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000004435Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000001219Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Loxodonta_africanaone2one ENSLAFG00000004893Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Cavia_porcellusone2one ENSCPOG00000014013Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Bos_taurusone2one ENSBTAG00000015413Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]RASA2
Spermophilus_tridecemlineatusone2one ENSSTOG00000010098Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Procavia_capensisone2one ENSPCAG00000001071Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Ochotona_princepsone2one ENSOPRG00000013386Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Tupaia_belangerione2one ENSTBEG00000001103Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Dipodomys_ordiione2one ENSDORG00000001995Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:P58069][hgnc]
Echinops_telfairione2one ENSETEG00000004169Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000000539Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Sorex_araneusone2one ENSSARG00000000794Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Mus_musculusone2one ENSMUSG00000032413Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:P58069][hgnc]Rasa2
Rattus_norvegicusone2one ENSRNOG00000011909Ras GTPase-activating protein 2 (GAP1m). [Source:UniProtKB/Swiss-Prot;Acc:Q63713][hgnc]Rasa2
Monodelphis_domesticaone2one ENSMODG00000021230Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000002775Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]100079072
Gallus_gallusone2one ENSGALG00000002850RAS p21 protein activator 2 [Source:RefSeq_peptide;Acc:NP_001012947][hgnc]RCJMB04_35e7
Xenopus_tropicalisone2one ENSXETG00000014755Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Oryzias_latipesone2one ENSORLG00000011646Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000007520Ras GTPase-activating protein 2 (GAP1m) [Source:UniProtKB/Swiss-Prot;Acc:Q15283][hgnc]
Ciona_intestinalisone2many ENSCING00000012766[hgnc]
Ciona_savignyione2many ENSCSAVG00000010428[hgnc]