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Summary sheet information for Effector 'SHC transforming protein 1-Homo sapiens'
Name SHC transforming protein 1-Homo sapiens
Description RecName: Full=SHC-transforming protein 1;AltName: Full=Src homology 2 domain-containing-transforming protein C1; Short=SH2 domain protein C1
Class
Family SHC transforming proteins
Sub_family SHC transforming proteins
type SHC transforming protein 1
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 1
Gene Start: 153201398
Gene End: 153213476
Ensembl Contig View
Ensembl Genes:
ENSG00000160691
EMBL:
EMBL ID  Description
AF455141  Homo sapiens Src homology 2 domain-containing transforming protein 1 isoform p66 and Src homology 2 domain-containing transforming protein 1 isoform p52 genes, alternative promoter regions, exons 1 and 2 and partial cds.
AK292143  Homo sapiens cDNA FLJ75052 complete cds, highly similar to Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), transcript variant 2, mRNA.
AK315842  Homo sapiens cDNA, FLJ79491 complete cds, highly similar to SHC-transforming protein 1.
AL451085  Human DNA sequence from clone RP11-307C12 on chromosome 1 Contains the PMVK gene for phosphomevalonate kinase, the PBXIP1 gene for pre-B-cell leukemia transcription factor interacting protein 1, the gene for pygopus 2 (PYGO2), the SHC1 gene for SHC (Src homology 2 domain containing) transforming protein 1, the CKS1B gene for CDC28 protein kinase regulatory subunit 1B, the gene for FAD-synthetase (PP591), the LENEP gene for lens epithelial protein, the ZFP67 gene for zinc finger protein 67 homolog (mouse), the gene for a novel protein (FLJ32934), a novel gene, the gene for a novel protein (FLJ32785) the 5' end of the ADAM15 gene for a disintegrin and metalloproteinase domain 15 (metargidin), and two CpG islands.
BC014158  Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1, mRNA (cDNA clone MGC:20839 IMAGE:4541216), complete cds.
BC033925  Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1, mRNA (cDNA clone MGC:39145 IMAGE:4896385), complete cds.
CH471121  Homo sapiens 211000035830426 genomic scaffold, whole genome shotgun sequence.
U73377  Human p66shc (SHC) mRNA, complete cds.
X68148  H.sapiens SHC mRNA
Y09847  H.sapiens shc gene, p66 isoform

EntrezGene:
ID  Description
SHC1  SHC (Src homology 2 domain containing) transforming protein 1
RefSeq DNA:
ID  Description
NM_001130040  Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), transcript variant 3, mRNA.
NM_001130041  Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), transcript variant 4, mRNA.
NM_003029  Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), transcript variant 2, mRNA.
NM_183001  Homo sapiens SHC (Src homology 2 domain containing) transforming protein 1 (SHC1), transcript variant 1, mRNA.

UniGene:
ID  Description
Proteins
Ensembl Proteins:
ENSP00000357432; ENSP00000357430; ENSP00000357434; ENSP00000357438; ENSP00000357428; ENSP00000357435; ENSP00000357426
Entrez Proteins:
AAB49972.1; AAH14158.1; AAH33925.1; AAM61859.1; AAM61860.1; BAF84832.1; BAF98733.1; CAA48251.1; CAA70977.1; CAI13245.1; CAI13246.1; CAI13247.1; CAI13248.1; CAI13249.1; CAI13250.1; CAI13251.1; CAI13252.1; CAI13253.1; CAI13254.1; EAW53168.1; EAW53169.1; EAW53170.1
RefSeq Proteins:
ID  Description
NP_001123512  SHC (Src homology 2 domain containing) transforming protein 1 isoform 3 [Homo sapiens].
NP_001123513  SHC (Src homology 2 domain containing) transforming protein 1 isoform 4 [Homo sapiens].
NP_003020  SHC (Src homology 2 domain containing) transforming protein 1 isoform 2 [Homo sapiens].
NP_892113  SHC (Src homology 2 domain containing) transforming protein 1 isoform 1 [Homo sapiens].

UniProt:
ID  Description
P29353-2  UNKNOWN
P29353-3  UNKNOWN
P29353-4  UNKNOWN
Q5T181  SubName: Full=SHC (Src homology 2 domain containing) transforming protein 1; Flags: Fragment;
Q5T182  SubName: Full=SHC (Src homology 2 domain containing) transforming protein 1; Flags: Fragment;
Q5T187  SubName: Full=SHC (Src homology 2 domain containing) transforming protein 1; Flags: Fragment;
Q5T188  SubName: Full=SHC (Src homology 2 domain containing) transforming protein 1; Flags: Fragment;
Q5T189  SubName: Full=SHC (Src homology 2 domain containing) transforming protein 1; Flags: Fragment;
Q8NFT0  SubName: Full=Src homology 2 domain-containing transforming protein 1 isoform p52; Flags: Fragment;
Q8NFT1  SubName: Full=Src homology 2 domain-containing transforming protein 1 isoform p66; Flags: Fragment;
P29353  RecName: Full=SHC-transforming protein 1; AltName: Full=Src homology 2 domain-containing-transforming protein C1; Short=SH2 domain protein C1;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     SHC transforming protein 1-Homo sapiens    

InterPro:
ID  Name
IPR011993  PH_type
IPR006020  PTB_PID
IPR000980  SH2
IPR006019  PID_domain
Pfam:
ID  Description
SH2  SH2 domain
PID  Phosphotyrosine interaction domain (PTB/PID)

Structure
PDB:
ID
1MIL
1N3H
1OY2
1QG1
1SHC
1TCE
1WCP
HSSP:
ID  Description
1a07  COMPLEX (TRANSFERASE/PEPTIDE)
1a08  COMPLEX (TRANSFERASE/PEPTIDE)
1a09  COMPLEX (TRANSFERASE/PEPTIDE)
1a1a  COMPLEX (TRANSFERASE/PEPTIDE)
1a1b  COMPLEX (TRANSFERASE/PEPTIDE)
1a1c  COMPLEX (TRANSFERASE/PEPTIDE)
1a1e  COMPLEX (TRANSFERASE/PEPTIDE)
1ab2  TRANSFERASE(PHOSPHOTRANSFERASE)
1aot  COMPLEX (PROTO-ONCOGENE/EARLY PROTEIN)
1aou  COMPLEX (PROTO-ONCOGENE/EARLY PROTEIN)
1bhf  COMPLEX (SH2 DOMAIN/INHIBITOR)
1bhh  SH2 DOMAIN
1bkl  V-SRC SH2 DOMAIN
1bkm  TRANSFORMING PROTEIN
1bm2  HORMONE/GROWTH FACTOR
1bmb  HORMONE/GROWTH FACTOR
1cj1  SIGNALING PROTEIN
1d1z  GENE REGULATION
1d4t  SIGNALING PROTEIN
1d4w  SIGNALING PROTEIN
1f1w  TRANSFERASE
1f2f  TRANSFERASE
1fbz  TRANSFERASE
1fhs  SH2 DOMAIN
1fyr  HORMONE/GROWTH FACTOR
1ghu  SRC HOMOLOGY 2 DOMAIN
1hcs  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1hct  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1ijr  TRANSFERASE/SIGNALING PROTEIN
1is0  TRANSFERASE
1ju5  PROTEIN BINDING/TRANSFERASE
1jwo  TRANSFERASE
1jyq  SIGNALING PROTEIN
1jyr  SIGNALING PROTEIN
1jyu  SIGNALING PROTEIN
1ka6  IMMUNE SYSTEM
1ka7  IMMUNE SYSTEM
1kc2  TRANSFERASE
1lcj  COMPLEX (KINASE/PEPTIDE)
1lkk  COMPLEX (TYROSINE KINASE/PEPTIDE)
1lkl  COMPLEX (TYROSINE KINASE/PEPTIDE)
1m27  SIGNALING PROTEIN, TRANSFERASE
1mil  TRANSFORMING PROTEIN
1n3h  SIGNALING PROTEIN
1nzl  TRANSFERASE
1nzv  TRANSFERASE
1o41  SIGNALING PROTEIN
1o42  SIGNALING PROTEIN
1o43  SIGNALING PROTEIN
1o44  SIGNALING PROTEIN
1o45  SIGNALING PROTEIN
1o46  SIGNALING PROTEIN
1o47  SIGNALING PROTEIN
1o48  SIGNALING PROTEIN
1o49  SIGNALING PROTEIN
1o4a  SIGNALING PROTEIN
1o4b  SIGNALING PROTEIN
1o4c  SIGNALING PROTEIN
1o4d  SIGNALING PROTEIN
1o4e  SIGNALING PROTEIN
1o4f  SIGNALING PROTEIN
1o4g  SIGNALING PROTEIN
1o4h  SIGNALING PROTEIN
1o4i  SIGNALING PROTEIN
1o4j  SIGNALING PROTEIN
1o4k  SIGNALING PROTEIN
1o4l  SIGNALING PROTEIN
1o4m  SIGNALING PROTEIN
1o4n  SIGNALING PROTEIN
1o4o  SIGNALING PROTEIN
1o4p  SIGNALING PROTEIN
1o4q  SIGNALING PROTEIN
1o4r  SIGNALING PROTEIN
1oy2  SIGNALING PROTEIN
1p13  TRANSFERASE
1qg1  HORMONE/GROWTH FACTOR
1rja  TRANSFERASE
1rpy  SIGNALING PROTEIN
1rqq  TRANSFERASE/SIGNALING PROTEIN
1sha  PHOSPHOTRANSFERASE
1shb  PHOSPHOTRANSFERASE
1shc  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1shd  COMPLEX(TRANSFERASE/PEPTIDE)
1skj  TYROSINE-PROTEIN KINASE
1spr  TRANSFERASE(PHOSPHOTRANSFERASE)
1sps  TRANSFERASE(PHOSPHOTRANSFERASE)
1tce  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1tze  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
1wqu  TRANSFERASE
1x0n  PEPTIDE BINDING PROTEIN
1zfp  COMPLEX (SIGNAL TRANSDUCTION/PEPTIDE)
2abl  TRANSFERASE
2aoa  TRANSFERASE
2aob  TRANSFERASE
2aug  SIGNALING PROTEIN
2dcr  TRANSFERASE
2dly  TRANSFERASE
2dx0  HYDROLASE
2ecd  SIGNALING PROTEIN
2eo3  SIGNALING PROTEIN
2eob  HYDROLASE
2eyv  SIGNALING PROTEIN
2gsb  SIGNALING PROTEIN
2h46  HORMONE/GROWTH FACTOR
2h5k  HORMONE/GROWTH FACTOR
2hdv  SIGNALING PROTEIN
2hdx  SIGNALING PROTEIN
2huw  HORMONE/GROWTH FACTOR
2jyq  TRANSFERASE
2qms  SIGNALING PROTEIN
3c7i  SPLICING
PSSH:
ID  Description
Q5T189  UNKNOWN
Q5T183  UNKNOWN
Q5T186  UNKNOWN
Q5T180  UNKNOWN
Q5T184  UNKNOWN
Q5T185  UNKNOWN
Q5T182  UNKNOWN
Q5T187  UNKNOWN
Q5T188  UNKNOWN
Q5T181  UNKNOWN
Q8NFT0  UNKNOWN
Q8NFT1  UNKNOWN
P29353  UNKNOWN
Diseases
OMIM:
OMIM ID  Name  Alt Name
600560  SHC TRANSFORMING PROTEIN; SHC1   SHCA p46, INCLUDED p52, INCLUDED p66, INCLUDED
Gene Ontology
GO:
GO ID  Description
GO:0000187  activation of MAPK activity
GO:0000786  nucleosome
GO:0001525  angiogenesis
GO:0001558  regulation of cell growth
GO:0003677  DNA binding
GO:0005068  transmembrane receptor protein tyrosine kinase adaptor protein activity
GO:0005158  insulin receptor binding
GO:0005159  insulin-like growth factor receptor binding
GO:0005515  protein binding
GO:0005543  phospholipid binding
GO:0005634  nucleus
GO:0005737  cytoplasm
GO:0005739  mitochondrion
GO:0005829  cytosol
GO:0005886  plasma membrane
GO:0006334  nucleosome assembly
GO:0007173  epidermal growth factor receptor signaling pathway
GO:0007176  regulation of epidermal growth factor receptor activity
GO:0007242  intracellular signaling cascade
GO:0007265  Ras protein signal transduction
GO:0007507  heart development
GO:0008284  positive regulation of cell proliferation
GO:0016337  cell-cell adhesion
GO:0031532  actin cytoskeleton reorganization
GO:0045840  positive regulation of mitosis
Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04062  Chemokine signaling pathway
hsa05220  Chronic myeloid leukemia
hsa04012  ErbB signaling pathway
hsa04510  Focal adhesion
hsa05214  Glioma
hsa04910  Insulin signaling pathway
hsa04650  Natural killer cell mediated cytotoxicity
hsa04722  Neurotrophin signaling pathway

Panther:
ID  Description
P00036  Interleukin signaling pathway
P00047  PDGF signaling pathway
P00031  Inflammation mediated by chemokine and cytokine signaling pathway
P04393  Ras Pathway
P00018  EGF receptor signaling pathway
P00034  Integrin signalling pathway
P00021  FGF signaling pathway
P00005  Angiogenesis
Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000160691 SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353] Pan_troglodytesone2one ENSPTRG00000001397PREDICTED: Pan troglodytes similar to SHC (Src homology 2 domain containing) transforming protein 1 (LOC473641), mRNA. [Source:RefSeq_dna;Acc:XR_024057][hgnc]LOC473641
Pongo_pygmaeusone2one ENSPPYG00000000769Putative uncharacterized protein DKFZp459K018. [Source:UniProtKB/TrEMBL;Acc:Q5R7W7][hgnc]
Macaca_mulattaone2one ENSMMUG00000006581SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Microcebus_murinusone2one ENSMICG00000007933SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Tarsius_syrichtaone2one ENSTSYG00000011380SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Equus_caballusone2one ENSECAG00000003967SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]LOC100063053
Tursiops_truncatusone2one ENSTTRG00000016176SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000000050SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000016188SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Cavia_porcellusone2one ENSCPOG00000024934SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Tupaia_belangerione2one ENSTBEG00000009552SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Bos_taurusone2one ENSBTAG00000019838SHC-transforming protein 1 (SH2 domain protein C1) (Src homology 2 domain-containing-transforming protein C1). [Source:UniProtKB/Swiss-Prot;Acc:Q0IIE2][hgnc]SHC1
Procavia_capensisone2one ENSPCAG00000014471SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Dipodomys_ordiione2one ENSDORG00000003763SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P98083][hgnc]
Dasypus_novemcinctusone2one ENSDNOG00000007651SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Myotis_lucifugusone2one ENSMLUG00000002396SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Felis_catusone2one ENSFCAG00000001346SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Ochotona_princepsone2one ENSOPRG00000000352SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Mus_musculusone2one ENSMUSG00000042626SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P98083][hgnc]EG433158
Rattus_norvegicusone2many ENSRNOG00000020657src homology 2 domain-containing transforming protein C1 [Source:RefSeq_peptide;Acc:NP_445969][hgnc]Shc1
Echinops_telfairione2one ENSETEG00000014122SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000000807SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Loxodonta_africanaone2one ENSLAFG00000009887SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Rattus_norvegicusone2many ENSRNOG00000029080[hgnc]
Sorex_araneusone2one ENSSARG00000002974SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Canis_familiarisone2one ENSCAFG00000017156SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]PYGO2
Monodelphis_domesticaone2one ENSMODG00000017139SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000014437SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Gallus_gallusone2one ENSGALG00000006863SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]SHC
Xenopus_tropicalisone2one ENSXETG00000015404SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000012077SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Oryzias_latipesone2one ENSORLG00000009745SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Takifugu_rubripesone2one ENSTRUG00000006487SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000018331SHC-transforming protein 1 (Src homology 2 domain-containing-transforming protein C1) (SH2 domain protein C1) [Source:UniProtKB/Swiss-Prot;Acc:P29353][hgnc]
Ciona_intestinalisone2many ENSCING00000006400[hgnc]