Human-gpDB    A database of human GPCRs, G-proteins, Effectors and their interactions

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	Summary sheet information for Effector 'Rac-Homo sapiens-3'
Name	Rac-Homo sapiens-3
Description	RecName: Full=Ras-related C3 botulinum toxin substrate 3;AltName: Full=p21-Rac3;Flags: Precursor
Class
Family	Small GTP-binding proteins
Sub_family	Rho small GTPases
type	Rac
Protein features link	Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction	Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes	Gene Location: Chromosome : 17 Gene Start : 77582821 Gene End : 77585366 Ensembl Contig View Ensembl Genes: ENSG00000169750 EMBL: EMBL ID    Description AF008591    Homo sapiens Rac3 (RAC3) mRNA, complete cds. AF498966    Homo sapiens small GTP binding protein RAC3 (RAC3) mRNA, complete cds. BC009605    Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3), mRNA (cDNA clone MGC:14757 IMAGE:4284122), complete cds. BC015197    Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3), mRNA (cDNA clone MGC:14729 IMAGE:4275237), complete cds. BT019443    Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) mRNA, complete cds. EntrezGene: ID    Description RAC3    ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) RefSeq DNA: ID    Description NM_005052    Homo sapiens ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) (RAC3), mRNA. UniGene: ID    Description
Proteins	Ensembl Proteins: ENSP00000304283 Entrez Proteins: AAC51667.1; AAH09605.1; AAH15197.1; AAM21113.1; AAV38250.1 RefSeq Proteins: ID    Description NP_005043    ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [Homo sapiens]. UniProt: ID    Description P60763    RecName: Full=Ras-related C3 botulinum toxin substrate 3; AltName: Full=p21-Rac3; Flags: Precursor;
Domains	SMART: - Hyperlink to SMART; - Hyperlink to ENSEMBL       Rac-Homo sapiens-3     InterPro: ID    Name IPR001806    Ras_trnsfrmng IPR013753    Ras IPR003578    GTPase_Rho IPR005225    Small_GTP_bd Pfam: ID    Description Ras    Ras family
Structure	PDB: ID 2C2H 2G0N 2IC5 2OV2 2QME HSSP: ID    Description 1a2b    ONCOGENE PROTEIN 1a4r    HYDROLASE 1aje    G-PROTEIN 1am4    COMPLEX (GTPASE-ACTIVATING/GTP-BINDING) 1an0    GTPASE 1cc0    SIGNALING PROTEIN 1cee    STRUCTURAL PROTEIN REGULATION 1cf4    TRANSFERASE 1cxz    SIGNALING PROTEIN 1doa    CELL CYCLE 1dpf    GENE REGULATION/SIGNALING PROTEIN 1ds6    SIGNALING PROTEIN 1e0a    SIGNALLING PROTEIN 1e96    SIGNALLING COMPLEX 1ees    STRUCTURAL PROTEIN 1foe    SIGNALING PROTEIN, IMMUNE SYSTEM/SIGNALI 1ftn    PROTO-ONCOGENE 1g4u    SIGNALING PROTEIN 1grn    GENE REGULATION 1gwn    GTPASE 1gzs    COMPLEX (TOXIN/CELL CYCLE PROTEIN) 1he1    SIGNALLING COMPLEX 1hh4    SINGAL PROTEIN INHIBITOR COMPLEX 1i4d    SIGNALING PROTEIN 1i4l    SIGNALING PROTEIN 1i4t    SIGNALING PROTEIN 1ki1    SIGNALING PROTEIN 1kmq    SIGNALING PROTEIN 1kz7    SIGNALING PROTEIN 1kzg    SIGNALING PROTEIN 1lb1    SIGNALING PROTEIN 1m7b    SIGNALING PROTEIN 1mh1    GTP-BINDING 1nf3    SIGNALING PROTEIN 1ow3    GENE REGULATION/SIGNALING PROTEIN 1ryf    HYDROLASE 1ryh    HYDROLASE 1s1c    SIGNALING PROTEIN 1tx4    COMPLEX(GTPASE ACTIVATN/PROTO-ONCOGENE) 1x86    SIGNALING PROTEIN/MEMBRANE PROTEIN 1xcg    SIGNALING PROTEIN ACTIVATOR/SIGNALING PR 1z2c    SIGNALING PROTEIN 2ase    SIGNALING PROTEIN 2atx    HYDROLASE 2c2h    SIGNALING PROTEIN 2cls    NUCLEOTIDE BINDING PROTEIN 2dfk    CELL CYCLE 2fju    SIGNALING PROTEIN,APOPTOSIS/HYDROLASE 2fv8    SIGNALING PROTEIN 2g0n    SIGNALING PROTEIN 2gcn    SIGNALING PROTEIN 2gco    SIGNALING PROTEIN 2gcp    SIGNALING PROTEIN 2h7v    SIGNALING PROTEIN 2ic5    SIGNALING PROTEIN 2j0v    NUCLEOTIDE-BINDING PROTEIN 2j1l    HYDROLASE 2ngr    HYDROLASE 2nty    SIGNALING PROTEIN 2nz8    SIGNALING PROTEIN,CELL CYCLE 2odb    PROTEIN BINDING 2ov2    PROTEIN BINDING/TRANSFERASE 2p2l    UNKNOWN FUNCTION 2q3h    STRUCTURAL GENOMICS 2qme    SIGNALING PROTEIN/TRANSFERASE 2qrz    CELL CYCLE 2rex    SIGNALING PROTEIN/LIPOPROTEIN 2rgn    SIGNALING PROTEIN COMPLEX 2rmk    MEMBRANE PROTEIN/TRANSFERASE 2v55    TRANSFERASE 2vrw    SIGNALING PROTEIN 3bji    SIGNALING PROTEIN 3bwd    PLANT PROTEIN 3c5c    SIGNALING PROTEIN 3eg5    SIGNALING PROTEIN PSSH: ID    Description P60763    UNKNOWN
Diseases	OMIM: OMIM ID    Name    Alt Name 602050    RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 3; RAC3    RHO FAMILY, SMALL GTP-BINDING PROTEIN RAC3
Gene Ontology	GO: GO ID    Description GO:0000166    nucleotide binding GO:0003924    GTPase activity GO:0005515    protein binding GO:0005525    GTP binding GO:0005622    intracellular GO:0005737    cytoplasm GO:0006813    potassium ion transport GO:0006886    intracellular protein transport GO:0006913    nucleocytoplasmic transport GO:0007165    signal transduction GO:0007264    small GTPase mediated signal transduction GO:0008324    cation transmembrane transporter activity GO:0012505    endomembrane system GO:0015031    protein transport GO:0016020    membrane GO:0030031    cell projection assembly GO:0030036    actin cytoskeleton organization GO:0031175    neurite development GO:0042995    cell projection GO:0050885    neuromuscular process controlling balance GO:0050905    neuromuscular process
Pathway	KEGG: KEGG PATHWAY ID    Name hsa04520    Adherens junction hsa04360    Axon guidance hsa04662    B cell receptor signaling pathway hsa05210    Colorectal cancer hsa04664    Fc epsilon RI signaling pathway hsa04510    Focal adhesion hsa04010    MAPK signaling pathway hsa04650    Natural killer cell mediated cytotoxicity hsa05212    Pancreatic cancer hsa05200    Pathways in cancer hsa04810    Regulation of actin cytoskeleton hsa04370    VEGF signaling pathway hsa05416    Viral myocarditis hsa04310    Wnt signaling pathway Panther: ID    Description P00008    Axon guidance mediated by Slit/Robo P00010    B cell activation P00053    T cell activation P00007    Axon guidance mediated by semaphorins P04393    Ras Pathway P00018    EGF receptor signaling pathway P00034    Integrin signalling pathway P00021    FGF signaling pathway P00009    Axon guidance mediated by netrin P00016    Cytoskeletal regulation by Rho GTPase P00029    Huntington disease
Chemicals	DrugBank: ID    Name    Synonyms HMDB: ID    Name    Synonyms
Orthology	Orthology Relations: Gene Gene Description Organism Orthology type Orthologs Orthologs Description ENSG00000169750 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763] Anopheles_gambiae one2many AGAP005445 [hgnc]AgaP_ENSANGG00000011739 Aedes_aegypti one2many AAEL009732 rac GTPase[hgnc] Ciona_intestinalis many2many ENSCING00000002335 Rac4 protein [Source:RefSeq_peptide;Acc:NP_001027963][hgnc]448957 Tursiops_truncatus one2one ENSTTRG00000001578 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Macaca_mulatta one2one ENSMMUG00000010895 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Tarsius_syrichta one2one ENSTSYG00000014772 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Cavia_porcellus one2one ENSCPOG00000013861 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Pongo_pygmaeus one2one ENSPPYG00000008763 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Bos_taurus one2one ENSBTAG00000022927 MGC166020 protein. [Source:UniProtKB/TrEMBL;Acc:A5PK69][hgnc]RAC3 Otolemur_garnettii one2one ENSOGAG00000012467 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Felis_catus one2one ENSFCAG00000011671 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Equus_caballus one2one ENSECAG00000014115 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Mus_musculus one2one ENSMUSG00000018012 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60764][hgnc]Rac3 Pteropus_vampyrus one2one ENSPVAG00000013285 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Echinops_telfairi one2one ENSETEG00000012902 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Loxodonta_africana one2one ENSLAFG00000011153 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Dipodomys_ordii one2one ENSDORG00000013521 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60764][hgnc] Procavia_capensis apprent_one2one ENSPCAG00000009949 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Monodelphis_domestica one2one ENSMODG00000003244 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Gasterosteus_aculeatus apprent_one2one ENSGACG00000015393 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Gallus_gallus one2one ENSGALG00000002859 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [Source:RefSeq_peptide;Acc:NP_990347][hgnc]RAC1 Takifugu_rubripes apprent_one2one ENSTRUG00000004543 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Microcebus_murinus apprent_one2one ENSMICG00000001114 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Oryzias_latipes apprent_one2one ENSORLG00000002677 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Tupaia_belangeri apprent_one2one ENSTBEG00000007272 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Danio_rerio one2one ENSDARG00000040651 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3) [Source:RefSeq_peptide;Acc:NP_001002754][hgnc]rac3 Drosophila_melanogaster many2many FBgn0010333 [hgnc]Rac1 Drosophila_melanogaster many2many FBgn0014011 [hgnc]Rac2 Canis_familiaris apprent_one2one ENSCAFG00000005922 Ras-related C3 botulinum toxin substrate 3 Precursor (p21-Rac3) [Source:UniProtKB/Swiss-Prot;Acc:P60763][hgnc] Ciona_intestinalis many2many ENSCING00000002330 Rac2 protein [Source:RefSeq_peptide;Acc:NP_001027787][hgnc]448954 Caenorhabditis_elegans many2many C09G12.8 ced-10 encodes a GTPase orthologous to human RAC1 (OMIM:602048) that is required for phagocytosis during programmed cell death and for migration of the distal tip cells of the somatic gonad. CED-10 functions in the engulfing cell during apoptosis, and is activated by a complex of CED-2(CrkII) and CED-5(DOCK180) to promote formation of the polarized cell extensions associated with cell corpse engulfment. [Source: WormBase][hgnc]ced-10 Ciona_intestinalis many2many ENSCING00000002350 Rac1 protein [Source:RefSeq_peptide;Acc:NP_001027692][hgnc]445702 Caenorhabditis_elegans many2many K03D3.10 rac-2 encodes a small Rho family GTPase that, along with CED-10 and MIG-2, is one of three C. elegans Rac-related proteins. genetic studies indicate that rac-2 functions redundantly with mig-2 and ced-10 to regulate CAN and PDE axon pathfinding and CAN cell migration. in addition, rac-2 functions slightly redundant with mig-2 during distal tip cell movement and slightly redundant with ced-10 during cell-corpse phagocytosis. as unc-73 mutations enhance rac-2 defects in axon pathfinding and CAN cell migration, UNC-73/Trio is a likely candidate to act upstream of RAC-2 and positively regulate its GTPase activity in vivo. further, as UNC-115 activity is required to mediate the morphogenetic effects of constitutively active RAC-2(G12V), UNC-115, an actin-binding protein, is likely to be a downstream effector of RAC-2. GFP::RAC-2 reporters expressed in neurons and neuroblasts reveal localization at cell margins and the nerve ring, the latter suggesting that GFP::RAC-2 associates with the axonal plasma membrane. [Source: WormBase][hgnc]rac-2 Ciona_intestinalis many2many ENSCING00000002345 Rac5 protein [Source:RefSeq_peptide;Acc:NP_001027789][hgnc]448958 Ciona_intestinalis many2many ENSCING00000002339 Rac3b protein (EC 3.6.1.47) (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q7YT76][hgnc]