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Summary sheet information for GPCR 'P2Y RECEPTORS_P2Y6_Homo sapiens'
Name P2Y RECEPTORS_P2Y6_Homo sapiens
Description RecName: Full=P2Y purinoceptor 6; Short=P2Y6
Class CLASS A
Family P2Y RECEPTORS
Sub_family P2Y6
type
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 11
Gene Start: 72653218
Gene End: 72687292
Ensembl Contig View
Ensembl Genes:
ENSG00000171631
EMBL:
EMBL ID  Description
AF007891  Homo sapiens P2Y6 receptor, short splice variant mRNA, complete cds.
AF007892  Homo sapiens P2Y6 receptor, long splice variant mRNA, complete cds.
AF218005  Homo sapiens clone PP2891 unknown mRNA.
AF498920  Homo sapiens pyrimidinergic receptor P2RY6 (P2RY6) mRNA, complete cds.
BC000571  Homo sapiens pyrimidinergic receptor P2Y, G-protein coupled, 6, mRNA (cDNA clone MGC:2067 IMAGE:3162734), complete cds.
BC009391  Homo sapiens pyrimidinergic receptor P2Y, G-protein coupled, 6, mRNA (cDNA clone MGC:15335 IMAGE:4128941), complete cds.
BT006771  Homo sapiens pyrimidinergic receptor P2Y, G-protein coupled, 6 mRNA, complete cds.
U52464  Human P2 purinoceptor (P2Y6) mRNA, complete cds.
X97058  H.sapiens mRNA for P2Y6 receptor

EntrezGene:
ID  Description
P2RY6  pyrimidinergic receptor P2Y, G-protein coupled, 6
RefSeq DNA:
ID  Description
NM_004154  Homo sapiens pyrimidinergic receptor P2Y, G-protein coupled, 6 (P2RY6), transcript variant 4, mRNA.
NM_176796  Homo sapiens pyrimidinergic receptor P2Y, G-protein coupled, 6 (P2RY6), transcript variant 3, mRNA.
NM_176797  Homo sapiens pyrimidinergic receptor P2Y, G-protein coupled, 6 (P2RY6), transcript variant 1, mRNA.
NM_176798  Homo sapiens pyrimidinergic receptor P2Y, G-protein coupled, 6 (P2RY6), transcript variant 2, mRNA.

UniGene:
ID  Description
Hs.16362  P2Y6 receptor pseudogene, complete sequence

Proteins
Ensembl Proteins:
ENSP00000377215; ENSP00000377216; ENSP00000377217; ENSP00000309771
Entrez Proteins:
AAB03572.1; AAB80712.1; AAB80713.1; AAG17247.1; AAH00571.1; AAH09391.1; AAM18129.1; AAP35417.1; CAA65770.1
RefSeq Proteins:
ID  Description
NP_004145  pyrimidinergic receptor P2Y6 [Homo sapiens].
NP_789766  pyrimidinergic receptor P2Y6 [Homo sapiens].
NP_789767  pyrimidinergic receptor P2Y6 [Homo sapiens].
NP_789768  pyrimidinergic receptor P2Y6 [Homo sapiens].

UniProt:
ID  Description
Q15077  RecName: Full=P2Y purinoceptor 6; Short=P2Y6;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR000276  GPCR_Rhodpsn
IPR001973  P2Y6_purnocptor
IPR017452  GPCR_Rhodpsn_supfam
IPR002286  P2_purnocptor
Pfam:
ID  Description
7tm_1  7 transmembrane receptor (rhodopsin family)

Structure
PDB:
ID
2B6R
HSSP:
ID  Description
PSSH:
ID  Description
Diseases
OMIM:
OMIM ID  Name  Alt Name
602451  PYRIMIDINERGIC RECEPTOR P2Y, G PROTEIN-COUPLED, 6; P2RY6   PURINOCEPTOR P2Y6; P2Y6
Gene Ontology
GO:
GO ID  Description
GO:0001584  rhodopsin-like receptor activity
GO:0004872  receptor activity
GO:0004966  galanin receptor activity
GO:0004982  N-formyl peptide receptor activity
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007200  activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
GO:0007596  blood coagulation
GO:0009055  electron carrier activity
GO:0015057  thrombin receptor activity
GO:0016020  membrane
GO:0016021  integral to membrane
GO:0016491  oxidoreductase activity
GO:0016494  C-X-C chemokine receptor activity
GO:0030321  transepithelial chloride transport
GO:0045028  purinergic nucleotide receptor activity, G-protein coupled
GO:0045029  UDP-activated nucleotide receptor activity
Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04080  Neuroactive ligand-receptor interaction

Panther:
ID  Description
Chemicals
DrugBank:
ID  Name  Synonyms
HMDB:
ID  Name  Synonyms
Other GPCR resources
Links to other GPCR resources
GPCRDB | GPCR-OKB | GLIDA
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000171631 P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077] Pan_troglodytesone2one ENSPTRG00000004043P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]P2RY6
Pongo_pygmaeusone2one ENSPPYG00000003659Putative uncharacterized protein DKFZp469D0314. [Source:UniProtKB/TrEMBL;Acc:Q5R5L6][hgnc]
Macaca_mulattaone2one ENSMMUG00000003138P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]
Tursiops_truncatusone2one ENSTTRG00000004717P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000015399P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]
Cavia_porcellusone2one ENSCPOG00000007948P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]
Bos_taurusone2one ENSBTAG00000038737Purinergic P2Y6 receptor (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q6QHU8][hgnc]P2RY6
Oryctolagus_cuniculusone2one ENSOCUG00000017568P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]
Felis_catusone2one ENSFCAG00000002867P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]
Canis_familiarisone2one ENSCAFG00000005628P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]P2RY6
Dasypus_novemcinctusone2one ENSDNOG00000018881P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]
Erinaceus_europaeusone2one ENSEEUG00000007903P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]
Mus_musculusone2one ENSMUSG00000048779P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q9ERK9][hgnc]P2ry6
Rattus_norvegicusone2one ENSRNOG00000019270P2Y purinoceptor 6 (P2Y6). [Source:UniProtKB/Swiss-Prot;Acc:Q63371][hgnc]P2ry6
Procavia_capensisone2one ENSPCAG00000000391P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]
Monodelphis_domesticaone2one ENSMODG00000024017P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]
Gallus_gallusone2one ENSGALG00000017327P2Y purinoceptor 3 (P2Y3) (Nucleoside diphosphate receptor). [Source:UniProtKB/Swiss-Prot;Acc:Q98907][hgnc]P2RY6
Xenopus_tropicalisone2one ENSXETG00000010724P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]
Gasterosteus_aculeatusone2one ENSGACG00000008198P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000010288P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]
Danio_rerioone2one ENSDARG00000042595[hgnc]LOC566099
Oryzias_latipesone2one ENSORLG00000010348P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]
Takifugu_rubripesone2one ENSTRUG00000006443P2Y purinoceptor 6 (P2Y6) [Source:UniProtKB/Swiss-Prot;Acc:Q15077][hgnc]
Ciona_intestinalisone2many ENSCING00000005420[hgnc]
Ciona_savignyione2many ENSCSAVG00000005816[hgnc]
Drosophila_melanogasterone2many FBgn0010770[hgnc]ppan
Anopheles_gambiaeone2many AGAP004556[hgnc]AgaP_ENSANGG00000009719