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Summary sheet information for GPCR 'P2Y RECEPTORS_P2Y2_Homo sapiens'
Name P2Y RECEPTORS_P2Y2_Homo sapiens
Description RecName: Full=P2Y purinoceptor 2; Short=P2Y2;AltName: Full=P2U purinoceptor 1; Short=P2U1;AltName: Full=ATP receptor;AltName: Full=Purinergic receptor
Class CLASS A
Family P2Y RECEPTORS
Sub_family P2Y2
type
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 11
Gene Start: 72606992
Gene End: 72625041
Ensembl Contig View
Ensembl Genes:
ENSG00000175591
EMBL:
EMBL ID  Description
AK313942  Homo sapiens cDNA, FLJ94584, highly similar to Homo sapiens purinergic receptor P2Y, G-protein coupled, 2 (P2RY2), mRNA.
AY136753  Homo sapiens purinergic receptor P2RY2 (P2RY2) mRNA, complete cds.
BC012104  Homo sapiens purinergic receptor P2Y, G-protein coupled, 2, mRNA (cDNA clone MGC:20088 IMAGE:4561430), complete cds.
BC028135  Homo sapiens purinergic receptor P2Y, G-protein coupled, 2, mRNA (cDNA clone MGC:40010 IMAGE:5215817), complete cds.
CH471076  Homo sapiens 211000035835228 genomic scaffold, whole genome shotgun sequence.
U07225  Homo sapiens P2U nucleotide receptor mRNA, complete cds.

EntrezGene:
ID  Description
P2RY2  purinergic receptor P2Y, G-protein coupled, 2
RefSeq DNA:
ID  Description
NM_002564  Homo sapiens purinergic receptor P2Y, G-protein coupled, 2 (P2RY2), transcript variant 2, mRNA.
NM_176071  Homo sapiens purinergic receptor P2Y, G-protein coupled, 2 (P2RY2), transcript variant 3, mRNA.
NM_176072  Homo sapiens purinergic receptor P2Y, G-protein coupled, 2 (P2RY2), transcript variant 1, mRNA.

UniGene:
ID  Description
Hs.339  Purinergic receptor P2RY2 (P2RY2)

Proteins
Ensembl Proteins:
ENSP00000377221; ENSP00000377222; ENSP00000310305
Entrez Proteins:
AAC04923.1; AAH12104.1; AAH28135.1; AAN01279.1; BAG36660.1; EAW74882.1
RefSeq Proteins:
ID  Description
NP_002555  purinergic receptor P2Y2 [Homo sapiens].
NP_788085  purinergic receptor P2Y2 [Homo sapiens].
NP_788086  purinergic receptor P2Y2 [Homo sapiens].

UniProt:
ID  Description
B2R9W3  SubName: Full=cDNA, FLJ94584, highly similar to Homo sapiens purinergic receptor P2Y, G-protein coupled, 2 (P2RY2), mRNA (Purinergic receptor P2Y, G-protein coupled, 2, isoform CRA_a);
P41231  RecName: Full=P2Y purinoceptor 2; Short=P2Y2; AltName: Full=P2U purinoceptor 1; Short=P2U1; AltName: Full=ATP receptor; AltName: Full=Purinergic receptor;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL

InterPro:
ID  Name
IPR000276  GPCR_Rhodpsn
IPR000356  P2U_purnocptor
IPR017452  GPCR_Rhodpsn_supfam
IPR002286  P2_purnocptor
Pfam:
ID  Description
7tm_1  7 transmembrane receptor (rhodopsin family)

Structure
PDB:
ID
1Z8E
HSSP:
ID  Description
PSSH:
ID  Description
Diseases
OMIM:
OMIM ID  Name  Alt Name
600041  PURINERGIC RECEPTOR P2Y, G PROTEIN-COUPLED, 2; P2RY2   PURINOCEPTOR P2Y2; P2Y2; P2Y2R P2U NUCLEOTIDE RECEPTOR; P2UR
Gene Ontology
GO:
GO ID  Description
GO:0001584  rhodopsin-like receptor activity
GO:0004872  receptor activity
GO:0004945  angiotensin type II receptor activity
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0006873  cellular ion homeostasis
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007200  activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger
GO:0007596  blood coagulation
GO:0015057  thrombin receptor activity
GO:0016021  integral to membrane
GO:0016494  C-X-C chemokine receptor activity
GO:0045028  purinergic nucleotide receptor activity, G-protein coupled
Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04080  Neuroactive ligand-receptor interaction

Panther:
ID  Description
Chemicals
DrugBank:
ID  Name  Synonyms
DB04786  Suramin  Bayer 205; SVR; Sodium suramin; Suramin sodium; Suramine; Suramine sodium
HMDB:
ID  Name  Synonyms
Other GPCR resources
Links to other GPCR resources
GPCRDB | GPCR-OKB | GLIDA
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000175591 P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231] Pan_troglodytesone2one ENSPTRG00000004042P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]P2RY2
Pongo_pygmaeusone2one ENSPPYG00000003658P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]
Macaca_mulattaone2one ENSMMUG00000019186P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]
Felis_catusone2one ENSFCAG00000009492P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]
Equus_caballusone2one ENSECAG00000010577P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]LOC100065753
Otolemur_garnettiione2one ENSOGAG00000000742P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]
Canis_familiarisone2one ENSCAFG00000005630P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]P2RY2
Myotis_lucifugusone2one ENSMLUG00000002983P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]
Bos_taurusone2one ENSBTAG00000039050P2Y purinoceptor 2 (P2Y2) (Fragment). [Source:UniProtKB/Swiss-Prot;Acc:O18951][hgnc]P2RY2
Pteropus_vampyrusone2one ENSPVAG00000015400P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]
Dipodomys_ordiione2one ENSDORG00000014962P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P35383][hgnc]
Cavia_porcellusone2one ENSCPOG00000002564P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]
Rattus_norvegicusone2one ENSRNOG00000019283P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor). [Source:UniProtKB/Swiss-Prot;Acc:P41232][hgnc]P2ry2
Mus_musculusone2one ENSMUSG00000032860P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P35383][hgnc]P2ry2
Ochotona_princepsone2one ENSOPRG00000009080P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000014477P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]100088651
Monodelphis_domesticaone2one ENSMODG00000007664P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]
Gallus_gallusone2one ENSGALG00000017328P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]P2RY2
Xenopus_tropicalisone2many ENSXETG00000010723Hypothetical protein MGC75941. [Source:UniProtKB/TrEMBL;Acc:Q6P852][hgnc]
Xenopus_tropicalisone2many ENSXETG00000025221P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor). [Source:UniProtKB/Swiss-Prot;Acc:P41231] [from human gene ENSG00000175591][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000008233P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]
Gasterosteus_aculeatusone2many ENSGACG00000008228P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]
Takifugu_rubripesone2one ENSTRUG00000005568P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]
Tetraodon_nigroviridisone2one ENSTNIG00000010291P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]
Danio_rerioone2many ENSDARG00000063545[hgnc]LOC799661
Danio_rerioone2many ENSDARG00000063549P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]
Oryzias_latipesone2one ENSORLG00000010300P2Y purinoceptor 2 (P2Y2) (P2U purinoceptor 1) (P2U1) (ATP receptor) (Purinergic receptor) [Source:UniProtKB/Swiss-Prot;Acc:P41231][hgnc]
Ciona_intestinalisone2many ENSCING00000005420[hgnc]
Ciona_savignyione2many ENSCSAVG00000005816[hgnc]
Drosophila_melanogasterone2many FBgn0010770[hgnc]ppan
Anopheles_gambiaeone2many AGAP004556[hgnc]AgaP_ENSANGG00000009719