Human-gpDB    A database of human GPCRs, G-proteins, Effectors and their interactions

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	Summary sheet information for Effector 'LARG RhoGEF-Homo sapiens'
Name	LARG RhoGEF-Homo sapiens
Description	RecName: Full=Rho guanine nucleotide exchange factor 12;AltName: Full=Leukemia-associated RhoGEF
Class
Family	Guanine nucleotide exchange factors
Sub_family	RhoGEFs
type	LARG RhoGEF
Protein features link	Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction	Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes	Gene Location: Chromosome : 11 Gene Start : 119713156 Gene End : 119865855 Ensembl Contig View Ensembl Genes: ENSG00000196914 EMBL: EMBL ID    Description AB002380    Homo sapiens mRNA for KIAA0382 protein, partial cds. AF180681    Homo sapiens guanine nucleotide exchange factor (LARG) mRNA, complete cds. BC063117    Homo sapiens Rho guanine nucleotide exchange factor (GEF) 12, mRNA (cDNA clone IMAGE:30353240), partial cds. EntrezGene: ID    Description ARHGEF12    Rho guanine nucleotide exchange factor (GEF) 12 RefSeq DNA: ID    Description NM_015313    Homo sapiens Rho guanine nucleotide exchange factor (GEF) 12 (ARHGEF12), mRNA. UniGene: ID    Description Hs.24598    KIAA0382 protein Hs.621937    Transcribed locus
Proteins	Ensembl Proteins: ENSP00000349056; ENSP00000380942 Entrez Proteins: AAF36817.1; AAH63117.1; BAA20836.2 RefSeq Proteins: ID    Description NP_056128    Rho guanine nucleotide exchange factor (GEF) 12 [Homo sapiens]. UniProt: ID    Description Q9NZN5-2    UNKNOWN Q9NZN5    RecName: Full=Rho guanine nucleotide exchange factor 12; AltName: Full=Leukemia-associated RhoGEF;
Domains	SMART: - Hyperlink to SMART; - Hyperlink to ENSEMBL InterPro: ID    Name IPR001849    PH IPR015721    RhoGEF_like IPR011993    PH_type IPR001331    GDS_CDC24_CS IPR000219    DH-domain IPR015212    Regulat_G_prot_signal-like IPR001478    PDZ Pfam: ID    Description PDZ    PDZ domain (Also known as DHR or GLGF) RhoGEF    RhoGEF domain RGS-like    Regulator of G protein signalling-like domain
Structure	PDB: ID 1TXD 1X86 2OMJ 2OS6 HSSP: ID    Description 1d5g    HYDROLASE 1gq5    SIGNALING PROTEIN 1htj    SIGNALING PROTEIN 1iap    SIGNALING PROTEIN 1q3o    PEPTIDE BINDING PROTEIN 1q3p    PEPTIDE BINDING PROTEIN 1shz    SIGNALING PROTEIN 1txd    SIGNALING PROTEIN 1u39    PROTEIN TRANSPORT 1ueq    SIGNALING PROTEIN 1wf8    PROTEIN BINDING 1wfv    SIGNALING PROTEIN 1wha    SIGNALING PROTEIN 1x5q    CELL ADHESION, CELL CYCLE 1x86    SIGNALING PROTEIN/MEMBRANE PROTEIN 1xcg    SIGNALING PROTEIN ACTIVATOR/SIGNALING PR 1y7n    PROTEIN TRANSPORT 2awu    MEMBRANE PROTEIN 2aww    MEMBRANE PROTEIN 2awx    MEMBRANE PROTEIN 2byg    SIGNAL TRANSDUCTION 2csj    CELL ADHESION 2djt    SIGNALING PROTEIN 2dkr    PROTEIN TRANSPORT 2dls    SIGNALING PROTEIN 2eeh    METAL BINDING PROTEIN 2eei    METAL BINDING PROTEIN 2eej    METAL BINDING PROTEIN 2egk    PROTEIN BINDING 2egn    PROTEIN BINDING 2ego    PROTEIN BINDING 2eno    ENDOCYTOSIS 2f5y    SIGNALING PROTEIN 2fcf    STRUCTURAL PROTEIN 2fe5    STRUCTURAL PROTEIN 2fn5    SIGNALING PROTEIN 2fne    STRUCTURAL GENOMICS, UNKNOWN FUNCTION 2g2l    MEMBRANE PROTEIN 2he4    STRUCTURAL GENOMICS, UNKNOWN FUNCTION 2i04    PEPTIDE BINDING PROTEIN 2i0l    PEPTIDE BINDING PROTEIN 2iwn    SIGNALING PROTEIN 2jik    MEMBRANE PROTEIN 2jil    MEMBRANE PROTEIN 2jin    MEMBRANE PROTEIN 2jxo    PROTEIN BINDING 2ogp    SIGNALING PROTEIN 2omj    CELL ADHESION 2oqs    PEPTIDE-BINDING PROTEIN 2os6    CELL ADHESION 2ozf    PROTEIN BINDING 2pnt    STRUCTURAL GENOMICS, UNKNOWN FUNCTION 2q9v    TRANSFERASE 2r4h    TRANSFERASE 2v90    PROTEIN-BINDING 2vz5    PROTEIN BINDING 2w4f    STRUCTURAL PROTEIN 2yuy    SIGNALING PROTEIN 2z0q    SIGNALING PROTEIN 3b76    LIGASE 3cx6    SIGNALING PROTEIN 3cx7    SIGNALING PROTEIN 3cx8    SIGNALING PROTEIN 3diw    SIGNALING PROTEIN/CELL ADHESION 3dj1    SIGNALING PROTEIN 3dj3    SIGNALING PROTEIN 3eo2    SPLICING 3pdz    HYDROLASE PSSH: ID    Description Q6P526    UNKNOWN Q9NZN5    UNKNOWN
Diseases	OMIM: OMIM ID    Name    Alt Name 604763    RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 12; ARHGEF12    RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR, LEUKEMIA-ASSOCIATED LEUKEMIA-ASSOCIATED RHO GEF; LARG KIAA0382 LARG/MLL FUSION GENE, INCLUDED
Gene Ontology	GO: GO ID    Description GO:0005085    guanyl-nucleotide exchange factor activity GO:0005089    Rho guanyl-nucleotide exchange factor activity GO:0005096    GTPase activator activity GO:0005515    protein binding GO:0005622    intracellular GO:0005737    cytoplasm GO:0007242    intracellular signaling cascade GO:0016020    membrane GO:0035023    regulation of Rho protein signal transduction
Pathway	KEGG: KEGG PATHWAY ID    Name hsa04360    Axon guidance hsa04810    Regulation of actin cytoskeleton hsa04270    Vascular smooth muscle contraction Panther: ID    Description
Chemicals	DrugBank: ID    Name    Synonyms HMDB: ID    Name    Synonyms
Orthology	Orthology Relations: Gene Gene Description Organism Orthology type Orthologs Orthologs Description ENSG00000196914 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5] Rattus_norvegicus one2one ENSRNOG00000008924 Rho guanine nucleotide exchange factor (GEF) 12 [Source:RefSeq_peptide;Acc:NP_001013264][hgnc]Arhgef12 Equus_caballus one2one ENSECAG00000022702 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Tupaia_belangeri one2one ENSTBEG00000007175 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Mus_musculus one2one ENSMUSG00000059495 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q8R4H2][hgnc]639868 Cavia_porcellus one2one ENSCPOG00000010479 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Tarsius_syrichta one2one ENSTSYG00000001229 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Microcebus_murinus one2one ENSMICG00000011152 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Sorex_araneus one2one ENSSARG00000003515 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Bos_taurus one2one ENSBTAG00000021343 Guanine nucleotide exchange factor. [Source:UniProtKB/TrEMBL;Acc:Q5DWF9][hgnc]ARHGEF12 Myotis_lucifugus one2one ENSMLUG00000003285 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Canis_familiaris one2one ENSCAFG00000011934 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]ARHGEF12 Tursiops_truncatus one2one ENSTTRG00000011693 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Pteropus_vampyrus one2one ENSPVAG00000011807 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Otolemur_garnettii one2one ENSOGAG00000010533 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Dasypus_novemcinctus one2one ENSDNOG00000000591 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Ochotona_princeps one2one ENSOPRG00000005412 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Oryctolagus_cuniculus one2one ENSOCUG00000005196 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Spermophilus_tridecemlineatus one2one ENSSTOG00000015856 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Vicugna_pacos one2one ENSVPAG00000010279 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Monodelphis_domestica one2one ENSMODG00000013134 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Procavia_capensis one2one ENSPCAG00000003051 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Pongo_pygmaeus one2one ENSPPYG00000003974 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Pan_troglodytes one2one ENSPTRG00000004393 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]ARHGEF12 Danio_rerio one2one ENSDARG00000030532 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Tetraodon_nigroviridis one2many ENSTNIG00000007786 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Takifugu_rubripes one2many ENSTRUG00000014895 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Loxodonta_africana one2one ENSLAFG00000013288 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Echinops_telfairi one2one ENSETEG00000000237 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Dipodomys_ordii one2one ENSDORG00000007308 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q8R4H2][hgnc] Erinaceus_europaeus one2one ENSEEUG00000011770 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Xenopus_tropicalis one2one ENSXETG00000017018 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Gallus_gallus one2one ENSGALG00000006663 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]ARHGEF12 Ciona_savignyi one2many ENSCSAVG00000003345 [hgnc] Ciona_intestinalis one2many ENSCING00000007425 [hgnc] Ornithorhynchus_anatinus one2one ENSOANG00000006268 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]100073922 Tetraodon_nigroviridis one2many ENSTNIG00000010274 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc] Takifugu_rubripes one2many ENSTRUG00000011716 Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF) [Source:UniProtKB/Swiss-Prot;Acc:Q9NZN5][hgnc]