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Summary sheet information for Effector 'Tubulin-Homo sapiens-15'
Name Tubulin-Homo sapiens-15
Description RecName: Full=Tubulin beta-3 chain;AltName: Full=Tubulin beta-III;AltName: Full=Tubulin beta-4
Class
Family Tubulins
Sub_family Tubulins
type Tubulin
Protein features link Protein Information from Dasty2 DAS Client
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level
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Genes
Gene Location:
Chromosome: 16
Gene Start: 88513168
Gene End: 88530006
Ensembl Contig View
Ensembl Genes:
ENSG00000198211
EMBL:
EMBL ID  Description
AB241540  Homo sapiens MC1R gene for melanocortin 1 receptor, complete cds, allele:Phe147delta.
AB241541  Homo sapiens MC1R gene for melanocortin 1 receptor, complete cds, allele:Thr157Ile.
AB241542  Homo sapiens MC1R gene for melanocortin 1 receptor, complete cds, allele:Pro159Thr.
AB241543  Homo sapiens MC1R gene for melanocortin 1 receptor, complete cds, allele:Ala166Gly.
AB241544  Homo sapiens MC1R gene for melanocortin 1 receptor, complete cds, allele:Ala166Ala.
AB241545  Homo sapiens MC1R gene for melanocortin 1 receptor, complete cds, allele:Arg67Gln.
AB241546  Homo sapiens MC1R gene for melanocortin 1 receptor, complete cds, allele:Val92Met.
AB241547  Homo sapiens MC1R gene for melanocortin 1 receptor, complete cds, allele:Ile120Thr.
AB241548  Homo sapiens MC1R gene for melanocortin 1 receptor, complete cds, allele:Arg151Cys.
AB241549  Homo sapiens MC1R gene for melanocortin 1 receptor, complete cds, allele:Arg163Gln.
AB241550  Homo sapiens MC1R gene for melanocortin 1 receptor, complete cds, allele:Thr314Thr.
AB241551  Homo sapiens MC1R gene for melanocortin 1 receptor, complete cds.
AF153431  Homo sapiens melanocortin 1 receptor (MC1R) gene, complete cds.
AF153432  Homo sapiens haplotype asp84glu melanocortin 1 receptor (MC1R) gene, complete cds.
AF153433  Homo sapiens haplotype arg151cys melanocortin 1 receptor (MC1R) gene, complete cds.
AF153434  Homo sapiens haplotype arg163gln melanocortin 1 receptor (MC1R) gene, complete cds.
AF153435  Homo sapiens haplotype arg67gln/arg163gln melanocortin 1 receptor (MC1R) gene, complete cds.
AF153436  Homo sapiens haplotype A942G melanocortin 1 receptor (MC1R) gene, complete cds.
AF153437  Homo sapiens haplotype val92met/A942G melanocortin 1 receptor (MC1R) gene, complete cds.
AF263461  Homo sapiens melanocortin 1 receptor (MC1R) gene, promoter region and complete cds.
AF326275  Homo sapiens melanocortin 1 receptor (MC1R) gene, complete cds.
AF427491  Homo sapiens class III beta tubulin mRNA, complete cds.
AF514787  Homo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (MC1R) gene, complete cds.
AF529884  Homo sapiens melanocortin 1 receptor variant L93R (MC1R) gene, complete cds.
AK223039  Homo sapiens mRNA for tubulin, beta, 4 variant, clone: JTH08432.
AK292219  Homo sapiens cDNA FLJ77784 complete cds.
AK314616  Homo sapiens cDNA, FLJ95457, highly similar to Homo sapiens tubulin, beta, 4 (TUBB4), mRNA.
AY046528  Homo sapiens melanocortin 1 receptor mutant I40T (MC1R) gene, complete cds.
AY046529  Homo sapiens melanocortin 1 receptor mutant V122M (MC1R) gene, complete cds.
AY225228  Homo sapiens melanocortin 1 receptor gene, complete cds.
AY363619  Homo sapiens melanocortin 1 receptor variant F45L (MC1R) gene, complete cds.
AY363620  Homo sapiens melanocortin 1 receptor variant S83L (MC1R) gene, complete cds.
AY363621  Homo sapiens melanocortin 1 receptor variant R160Q (MC1R) gene, complete cds.
AY363622  Homo sapiens melanocortin 1 receptor variant R213W (MC1R) gene, complete cds.
AY363623  Homo sapiens melanocortin 1 receptor variant T308M (MC1R) gene, complete cds.
AY363624  Homo sapiens melanocortin 1 receptor variant C315R (MC1R) gene, complete cds.
AY363625  Homo sapiens melanocortin 1 receptor variant A111V (MC1R) gene, complete cds.
AY363626  Homo sapiens melanocortin 1 receptor variant A222T (MC1R) gene, complete cds.
AY363627  Homo sapiens melanocortin 1 receptor variant V265I (MC1R) gene, complete cds.
BC000748  Homo sapiens tubulin, beta 3, mRNA (cDNA clone MGC:2411 IMAGE:2823044), complete cds.
BC001678  Homo sapiens tubulin, beta 3, mRNA (cDNA clone IMAGE:2821278), partial cds.
BC003021  Homo sapiens tubulin, beta 3, mRNA (cDNA clone MGC:4055 IMAGE:2823044), complete cds.
BC007856  Homo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor), mRNA (cDNA clone MGC:14337 IMAGE:4298428), complete cds.
BC047518  Homo sapiens tubulin, beta 3, mRNA (cDNA clone IMAGE:5276469), partial cds.
BC080622  Homo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor), mRNA (cDNA clone MGC:99464 IMAGE:6267157), complete cds.
BT006971  Homo sapiens tubulin, beta, 4 mRNA, complete cds.
CH471184  Homo sapiens 211000035833700 genomic scaffold, whole genome shotgun sequence.
EU151499  Homo sapiens melanocortin 1 receptor gene, complete cds.
U47634  Human beta-tubulin class III isotype (beta-3) mRNA, complete cds.
X65634  H.sapiens MSH-R gene for melanocyte stimulating hormone receptor
X67594  H.sapiens mRNA for MSH receptor.

EntrezGene:
ID  Description
MC1R  melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
TUBB3  tubulin, beta 3
RefSeq DNA:
ID  Description
NM_002386  Homo sapiens melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) (MC1R), mRNA.
NM_006086  Homo sapiens tubulin, beta 3 (TUBB3), mRNA.

UniGene:
ID  Description
Proteins
Ensembl Proteins:
ENSP00000320295; ENSP00000302777
Entrez Proteins:
AAC52035.1; AAD41349.1; AAD41350.1; AAD41351.1; AAD41352.1; AAD41353.1; AAD41354.1; AAD41355.1; AAH00748.1; AAH01678.2; AAH03021.2; AAH07856.1; AAH47518.1; AAH80622.1; AAK01121.1; AAK58525.1; AAL05887.1; AAL05888.1; AAL28094.1; AAM44861.1; AAO21073.1; AAO67713.1; AAP35617.1; AAQ62969.1; AAQ62970.1; AAQ62971.1; AAQ62972.1; AAQ62973.1; AAQ62974.1; AAQ62975.1; AAQ62976.1; AAQ62977.1; ABV80299.1; BAD96759.1; BAE94306.1; BAE94307.1; BAE94308.1; BAE94309.1; BAE94310.1; BAE94311.1; BAE94312.1; BAE94313.1; BAE94314.1; BAE94315.1; BAE94316.1; BAE94317.1; BAF84908.1; BAG37182.1; CAA46588.1; CAA47865.1; EAW66674.1; EAW66675.1; EAW66676.1
RefSeq Proteins:
ID  Description
NP_002377  melanocortin 1 receptor [Homo sapiens].
NP_006077  tubulin, beta, 4 [Homo sapiens].

UniProt:
ID  Description
A8I0M1  SubName: Full=Melanocortin 1 receptor;
A8K854  SubName: Full=cDNA FLJ16289 fis, clone OCBBF2009920, highly similar to TUBULIN BETA-3 CHAIN; SubName: Full=cDNA FLJ77784; SubName: Full=HCG1983504, isoform CRA_f;
B2RBD5  SubName: Full=cDNA, FLJ95457, highly similar to Homo sapiens tubulin, beta, 4 (TUBB4), mRNA;
Q1JUL4  SubName: Full=Melanocortin 1 receptor (Alpha melanocyte stimulating hormone receptor) (cDNA FLJ14170 fis, clone NT2RP2002105, highly similar to Melanocyte-stimulating hormone receptor);
Q1JUL6  SubName: Full=Melanocortin 1 receptor;
Q1JUL8  SubName: Full=Melanocortin 1 receptor;
Q1JUL9  SubName: Full=Melanocortin 1 receptor;
Q1JUM0  SubName: Full=Melanocortin 1 receptor;
Q1JUM2  SubName: Full=Melanocortin 1 receptor;
Q1JUM3  SubName: Full=Melanocortin 1 receptor;
Q1JUM4  SubName: Full=Melanocortin 1 receptor;
Q1JUM5  SubName: Full=Melanocortin 1 receptor;
Q3ZCR3  SubName: Full=TUBB3 protein; Flags: Fragment;
Q53G92  SubName: Full=Tubulin, beta, 4 variant; Flags: Fragment;
Q66K38  SubName: Full=Melanocortin 1 receptor (Alpha melanocyte stimulating hormone receptor);
Q6UR92  SubName: Full=Melanocortin 1 receptor variant V265I;
Q6UR93  SubName: Full=Melanocortin 1 receptor variant A222T;
Q6UR94  SubName: Full=Melanocortin 1 receptor variant A111V;
Q6UR95  SubName: Full=Melanocortin 1 receptor variant C315R;
Q6UR96  SubName: Full=Melanocortin 1 receptor variant T308M;
Q6UR97  SubName: Full=Melanocortin 1 receptor variant R213W;
Q6UR98  SubName: Full=Melanocortin 1 receptor variant R160Q;
Q6UR99  SubName: Full=Melanocortin 1 receptor variant S83L;
Q6URA0  SubName: Full=Melanocortin 1 receptor variant F45L;
Q7KZS6  SubName: Full=Tubulin, beta, 4; SubName: Full=HCG2042771;
Q86YW1  SubName: Full=Melanocortin 1 receptor variant L93R;
Q9BV28  SubName: Full=TUBB3 protein; Flags: Fragment;
Q01726  RecName: Full=Melanocyte-stimulating hormone receptor; Short=MSH-R; AltName: Full=Melanotropin receptor; AltName: Full=Melanocortin receptor 1; AltName: Full=MC1-R;
Q13509  RecName: Full=Tubulin beta-3 chain; AltName: Full=Tubulin beta-III; AltName: Full=Tubulin beta-4;

Domains
SMART:
- Hyperlink to SMART; - Hyperlink to ENSEMBL
     Tubulin-Homo sapiens-15    

InterPro:
ID  Name
IPR017975  Tubulin_CS
IPR000276  GPCR_Rhodpsn
IPR000158  Cell_division_FtsZ_N
IPR001671  Melcrt_ACTH_rcpt
IPR000761  MSH_rcpt
IPR008280  Tub_FtsZ_C
IPR013838  Beta-tubulin_BS
IPR002453  Beta_tubulin
IPR003008  Tubulin_FtsZ
IPR000217  Tubulin
IPR010916  TonB_box_CS
IPR017452  GPCR_Rhodpsn_supfam
IPR001680  WD40_repeat
Pfam:
ID  Description
7tm_1  7 transmembrane receptor (rhodopsin family)
Tubulin  Tubulin/FtsZ family, GTPase domain
Tubulin_C  Tubulin/FtsZ family, C-terminal domain

Structure
PDB:
ID
HSSP:
ID  Description
1ffx  STRUCTURAL PROTEIN
1ia0  TRANSPORT PROTEIN
1jff  STRUCTURAL PROTEIN
1sa0  CELL CYCLE
1sa1  CELL CYCLE
1tub  MICROTUBULES
1tvk  CELL CYCLE, STRUCTURAL PROTEIN
1z2b  CELL CYCLE
1z5v  STRUCTURAL PROTEIN
1z5w  STRUCTURAL PROTEIN
2bto  CYTOSKELETAL PROTEIN
2btq  CYTOSKELETAL PROTEIN/COMPLEX
2hxf  TRANSPORT PROTEIN
2hxh  TRANSPORT PROTEIN
2p4n  TRANSPORT PROTEIN
3cb2  STRUCTURAL PROTEIN, HYDROLASE
3dco  MOTOR PROTEIN
3du7  CELL CYCLE
3e22  CELL CYCLE
3edl  STRUCTURAL PROTEIN
PSSH:
ID  Description
Q53G92  UNKNOWN
Q66K38  UNKNOWN
Q6UR93  UNKNOWN
Q6URA0  UNKNOWN
Q6UR97  UNKNOWN
Q6UR92  UNKNOWN
Q6UR99  UNKNOWN
Q6UR95  UNKNOWN
Q6UR96  UNKNOWN
Q6UR94  UNKNOWN
Q6UR98  UNKNOWN
Q7KZS6  UNKNOWN
Q86YW1  UNKNOWN
Q9BV28  UNKNOWN
Q01726  UNKNOWN
Q1JUM5  UNKNOWN
Q1JUM2  UNKNOWN
Q1JUM0  UNKNOWN
Q1JUL4  UNKNOWN
Q1JUL6  UNKNOWN
Q1JUL9  UNKNOWN
Q1JUM4  UNKNOWN
Q1JUL8  UNKNOWN
Q1JUM3  UNKNOWN
Q3ZCR3  UNKNOWN
Diseases
OMIM:
OMIM ID  Name  Alt Name
155555  MELANOCORTIN 1 RECEPTOR; MC1R   MELANOCYTE-STIMULATING HORMONE RECEPTOR; MSHR MELANOTROPIN RECEPTOR ANALGESIA FROM KAPPA-OPIOID RECEPTOR AGONIST, FEMALE-SPECIFIC, INCLUDED MELANOMA, CUTANEOUS MALIGNANT, SUSCEPTIBILITY TO, 5, INCLUDED; CMM5, INCLUDED
Gene Ontology
GO:
GO ID  Description
GO:0000166  nucleotide binding
GO:0001584  rhodopsin-like receptor activity
GO:0003924  GTPase activity
GO:0004872  receptor activity
GO:0004977  melanocortin receptor activity
GO:0004980  melanocyte stimulating hormone receptor activity
GO:0005198  structural molecule activity
GO:0005525  GTP binding
GO:0005737  cytoplasm
GO:0005874  microtubule
GO:0005886  plasma membrane
GO:0005887  integral to plasma membrane
GO:0007017  microtubule-based process
GO:0007018  microtubule-based movement
GO:0007067  mitosis
GO:0007165  signal transduction
GO:0007186  G-protein coupled receptor protein signaling pathway
GO:0007187  G-protein signaling, coupled to cyclic nucleotide second messenger
GO:0007275  multicellular organismal development
GO:0009650  UV protection
GO:0015630  microtubule cytoskeleton
GO:0016021  integral to membrane
GO:0030182  neuron differentiation
GO:0043234  protein complex
GO:0051258  protein polymerization
Pathway
KEGG:
KEGG PATHWAY ID  Name
hsa04916  Melanogenesis
hsa04080  Neuroactive ligand-receptor interaction
hsa04540  Gap junction
hsa05130  Pathogenic Escherichia coli infection

Panther:
ID  Description
P00016  Cytoskeletal regulation by Rho GTPase
P00029  Huntington disease
Chemicals
DrugBank:
ID  Name  Synonyms
DB03010  Epothilone B  EPO 906; EPO906; patupilone
DB01873  Epothilone D  KOS-862; epothilone D
HMDB:
ID  Name  Synonyms
Orthology
Orthology Relations:
Gene Gene Description Organism Orthology type Orthologs Orthologs Description
ENSG00000198211 Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509] Pan_troglodytesone2one ENSPTRG00000008496Melanocyte-stimulating hormone receptor (MSH-R) (Melanotropin receptor) (Melanocortin receptor 1) (MC1-R). [Source:UniProtKB/Swiss-Prot;Acc:Q9TUK4][hgnc]LOC743110
Microcebus_murinusone2one ENSMICG00000000079Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Tursiops_truncatusone2one ENSTTRG00000005014Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Pteropus_vampyrusone2one ENSPVAG00000003011Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Spermophilus_tridecemlineatusone2one ENSSTOG00000001268Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Oryctolagus_cuniculusone2one ENSOCUG00000013617Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Tupaia_belangerione2one ENSTBEG00000000469Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Cavia_porcellusone2one ENSCPOG00000002380Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Equus_caballusone2one ENSECAG00000012818Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]LOC100052716
Otolemur_garnettiione2one ENSOGAG00000004909Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Felis_catusone2one ENSFCAG00000003798Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Ornithorhynchus_anatinusone2one ENSOANG00000002346Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Sorex_araneusone2one ENSSARG00000001771Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Dipodomys_ordiione2one ENSDORG00000015304Tubulin beta-3 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9ERD7][hgnc]
Bos_taurusone2one ENSBTAG00000023730Tubulin beta-3 chain. [Source:UniProtKB/Swiss-Prot;Acc:Q2T9S0][hgnc]TUBB3
Canis_familiarisone2one ENSCAFG00000019807Class III beta-tubulin (Fragment). [Source:UniProtKB/TrEMBL;Acc:Q9N0F8][hgnc]TUBB3
Macaca_mulattaone2one ENSMMUG00000029059Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Myotis_lucifugusone2one ENSMLUG00000015557Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Pongo_pygmaeusone2one ENSPPYG00000007678Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Procavia_capensisone2one ENSPCAG00000004022Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Ochotona_princepsone2one ENSOPRG00000003036Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Echinops_telfairione2one ENSETEG00000011447Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Mus_musculusone2one ENSMUSG00000062380Tubulin beta-3 chain [Source:UniProtKB/Swiss-Prot;Acc:Q9ERD7][hgnc]LOC632223
Rattus_norvegicusone2one ENSRNOG00000017209Tubulin beta-3 chain (Neuron-specific class III beta-tubulin). [Source:UniProtKB/Swiss-Prot;Acc:Q4QRB4][hgnc]Tubb3
Monodelphis_domesticaone2one ENSMODG00000023092Tubulin beta-3 chain (Tubulin beta-III) (Tubulin beta-4) [Source:UniProtKB/Swiss-Prot;Acc:Q13509][hgnc]
Caenorhabditis_elegansone2many ZK154.3mec-7 encodes a beta-tubulin required for touch sensitivity along the body wall, and for normal levels of locomotor activity. it is strongly expressed in six touch receptor neurons, with weak expression in FLP, PVD, and BDU cells. [Source: WormBase][hgnc]mec-7
Saccharomyces_cerevisiaeone2many YFL037WTubulin beta chain (Beta-tubulin). [Source:UniProtKB/Swiss-Prot;Acc:P02557][hgnc]TUB2