Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Description

Entry page for Effector - 'GRK3-Homo sapiens'

Family	Ser Thr protein kinases
Sub-Family	G protein coupled receptor kinases
Type	GRK3

Cross References:

References

UniProt	P35626 \| Q9UGW9
EMBL	X69117 \| AL022329
InterPro	IPR000961 \| IPR015743 \| IPR000239 \| IPR011993 \| IPR001849 \| IPR000719 \| IPR017441 \| IPR000342 \| IPR017442 \| IPR008271 \| IPR002290
PRODOM	PD000001
GENEID	157
MIM	109636
PRINTS	PR00717
PFAM	PF00169 \| PF00069 \| PF00615

Details:

Details

Name	GRK3-Homo sapiens
Description	RecName: Full=Beta-adrenergic receptor kinase 2; Short=Beta-ARK-2; EC=2.7.11.15;AltName: Full=G-protein-coupled receptor kinase 3
Species	Homo sapiens
Common Name	Human
NCBI Taxonomy	9606
Gene	ADRBK2 \| BARK2,GRK
Function	Specifically phosphorylates the agonist-occupied form ofs the beta-adrenergic and closely related receptors
Fragment	0
Sequence	MADLEAVLADVSYLMAMEKSKATPAARASKRIVLPEPSIRSVMQKYLAERNEITFDKIFN QKIGFLLFKDFCLNEINEAVPQVKFYEEIKEYEKLDNEEDRLCRSRQIYDAYIMKELLSC SHPFSKQAVEHVQSHLSKKQVTSTLFQPYIEEICESLRGDIFQKFMESDKFTRFCQWKNV ELNIHLTMNEFSVHRIIGRGGFGEVYGCRKADTGKMYAMKCLDKKRIKMKQGETLALNER IMLSLVSTGDCPFIVCMTYAFHTPDKLCFILDLMNGGDLHYHLSQHGVFSEKEMRFYATE IILGLEHMHNRFVVYRDLKPANILLDEHGHARISDLGLACDFSKKKPHASVGTHGYMAPE VLQKGTAYDSSADWFSLGCMLFKLLRGHSPFRQHKTKDKHEIDRMTLTVNVELPDTFSPE LKSLLEGLLQRDVSKRLGCHGGGSQEVKEHSFFKGVDWQHVYLQKYPPPLIPPRGEVNAA DAFDIGSFDEEDTKGIKLLDCDQELYKNFPLVISERWQQEVTETVYEAVNADTDKIEARK RAKNKQLGHEEDYALGKDCIMHGYMLKLGNPFLTQWQRRYFYLFPNRLEWRGEGESRQNL LTMEQILSVEETQIKDKKCILFRIKGGKQFVLQCESDPEFVQWKKELNETFKEAQRLLRR APKFLNKPRSGTVELPKPSLCHRNSNGL

Interacting with G-proteins:

G-proteins

No	Name	Regulation	PubMed
1	Ggamma-8_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
2	Galpha-q_Homo sapiens	Stimulation	15251227 \| 14654303 \| 16182515
3	Ggamma-4_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
4	Ggamma-5_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
5	Gbeta-4_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
6	Ggamma-11_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
7	Gbeta-5_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
8	Galpha-11_Homo sapiens	Stimulation	15251227 \| 14654303 \| 16182515
9	Gbeta-1_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
10	Ggamma-2_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
11	Gbeta-like_Homo sapiens_1	Recruitment to plasma membrane	15251227 \| 14654303
12	Ggamma-t1_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
13	Ggamma-10_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
14	Ggamma-12_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
15	Ggamma-13_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
16	Ggamma-t2_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
17	Gbeta-3_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
18	Ggamma-7_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
19	Gbeta-like_Homo sapiens_2	Recruitment to plasma membrane	15251227 \| 14654303
20	Gbeta-2_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
21	Ggamma-3_Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level