Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Description

Entry page for Effector - 'Phospholipase C beta 1-Homo sapiens'

Family	Phospholipases C
Sub-Family	Phospholipases C beta
Type	Phospholipase C beta 1

Cross References:

References

UniProt	Q9NQ66 \| O60325 \| Q5TFF7 \| Q5TGC9 \| Q8IV93 \| Q9BQW2 \| Q9H4H2 \| Q9H8H5
EMBL	AJ278313 \| AJ278314 \| AY004175 \| AB011153 \| AL031683 \| AL034551 \| AL049593 \| AL049632 \| AL050315 \| AL050323 \| AL031683 \| AL034551 \| AL050315 \| AL049632 \| AL050323 \| AL034551 \| AL031683 \| AL049593 \| AL049632 \| AL050315 \| AL050323 \| AL034551 \| AL031683 \| AL050315 \| AL049632 \| AL050323 \| AL049593 \| AL031683 \| AL034551 \| AL049632 \| AL050315 \| AL050323 \| AL049632 \| AL031683 \| AL034551 \| AL049593 \| AL050315 \| AL050323 \| AL049632 \| AL031683 \| AL034551 \| AL050315 \| AL050323 \| AL050315 \| AL031683 \| AL034551 \| AL049593 \| AL049632 \| AL050323 \| AL050315 \| AL031683 \| AL034551 \| AL049632 \| AL050323 \| AL050323 \| AL031683 \| AL034551 \| AL049593 \| AL049632 \| AL050315 \| AL050323 \| AL031683 \| AL034551 \| AL050315 \| AL049632 \| BC069420 \| AL137267 \| AK023689
InterPro	IPR000008 \| IPR018029 \| IPR011992 \| IPR015359 \| IPR001192 \| IPR000909 \| IPR001711 \| IPR016280 \| IPR014815 \| IPR017946
PRODOM	PD001202
GENEID	23236
MIM	607120
PRINTS	PR00390
PFAM	PF00168 \| PF09279 \| PF00388 \| PF00387 \| PF08703

Details:

Details

Name	Phospholipase C beta 1-Homo sapiens
Description	"RecName: Full=1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1; EC=3.1.4.11;AltName: Full=Phosphoinositide phospholipase C;AltName: Full=Phospholipase C-beta-1; Short=PLC-beta-1;AltName: Full=PLC-I;AltName: Full=PLC-154;"
Species	Homo sapiens
Common Name	Human
NCBI Taxonomy	9606
Gene	PLCB1 \| KIAA058
Function	The production of the second messenger moleculess diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) iss mediated by activated phosphatidylinositol-specific phospholipases C enzymes
Fragment	0
Sequence	MAGAQPGVHALQLKPVCVSDSLKKGTKFVKWDDDSTIVTPIILRTDPQGFFFYWTDQNKE TELLDLSLVKDARCGRHAKAPKDPKLRELLDVGNIGRLEQRMITVVYGPDLVNISHLNLV AFQEEVAKEWTNEVFSLATNLLAQNMSRDAFLEKAYTKLKLQVTPEGRIPLKNIYRLFSA DRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYL TVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLS GEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCV ELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQ QAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYKILVKNKKKSHKSSEGSGKK KLSEQASNTYSDSSSMFEPSSPGAGEADTESDDDDDDDDCKKSSMDEGTAGSEAMATEEM SNLVNYIQPVKFESFEISKKRNKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPK GTRVDSSNYMPQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDK HFDPFTEGIVDGIVANTLSVKIISGQFLSDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQG NAVNPVWEEEPIVFKKVVLPTLACLRIAVYEEGGKFIGHRILPVQAIRPGYHYICLRNER NQPLTLPAVFVYIEVKDYVPDTYADVIEALSNPIRYVNLMEQRAKQLAALTLEDEEEVKK EADPGETPSEAPSEARTTPAENGVNHTTTLTPKPPSQALHSQPAPGSVKAPAKTEDLIQS VLTEVEAQTIEELKQQKSFVKLQKKHYKEMKDLVKRHHKKTTDLIKEHTTKYNEIQNDYL RRRAALEKSAKKDSKKKSEPSSPDHGSSTIEQDLAALDAEMTQKLIDLKDKQQQQLLNLR QEQYYSEKYQKREHIKLLIQKLTDVAEECQNNQLKKLKEICEKEKKELKKKMDKKRQEKI TEAKSKDKSQMEEEKTEMIRSYIQEVVQYIKRLEEAQSKRQEKLVEKHKEIRQQILDEKP KLQVELEQEYQDKFKRLPLEILEFVQEAMKGKISEDSNHGSAPLSLSSDPGKVNHKTPSS EELGGDIPGKEFDTPL

Interacting with G-proteins:

G-proteins

No	Name	Regulation	PubMed
1	Ggamma-8_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
2	Galpha-q_Homo sapiens	Stimulation of PLC-beta catalytic activity	15251227 \| 16182515 \| 11015615
3	Ggamma-4_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
4	Ggamma-5_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
5	Gbeta-4_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
6	Ggamma-11_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
7	Gbeta-5_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
8	Galpha-11_Homo sapiens	Stimulation of PLC-beta catalytic activity	15251227 \| 16182515 \| 11015615
9	Gbeta-1_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
10	Ggamma-2_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
11	Gbeta-like_Homo sapiens_1	Stimulation	15251227 \| 11015615 \| 8383116
12	Ggamma-t1_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
13	Ggamma-10_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
14	Ggamma-12_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
15	Ggamma-13_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
16	Ggamma-t2_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
17	Gbeta-3_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
18	Galpha-14_Homo sapiens	Stimulation of PLC-beta catalytic activity	15251227 \| 16182515 \| 11015615
19	Ggamma-7_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
20	Gbeta-like_Homo sapiens_2	Stimulation	15251227 \| 11015615 \| 8383116
21	Gbeta-2_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
22	Ggamma-3_Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
23	Galpha-15_Homo sapiens	Stimulation of PLC-beta catalytic activity	15251227 \| 16182515 \| 11015615

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level