Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

home browse blast search advanced search help

Quick search:

Description

Entry page for Effector - 'SHC transforming protein 2-Homo sapiens'

Family	SHC transforming proteins
Sub-Family	SHC transforming proteins
Type	SHC transforming protein 2

Cross References:

References

UniProt	P98077 \| O60230 \| Q9NPL5 \| Q9UCX4
EMBL	AC008988 \| AC138433 \| AC006124 \| AB001451 \| AL360254
InterPro	IPR011993 \| IPR006019 \| IPR006020 \| IPR000980
PRODOM	PD000093
GENEID	25759
MIM	605217
PRINTS	PR00401 \| PR00629
PFAM	PF00640 \| PF00017

Details:

Details

Name	SHC transforming protein 2-Homo sapiens
Description	RecName: Full=SHC-transforming protein 2;AltName: Full=Src homology 2 domain-containing-transforming protein C2; Short=SH2 domain protein C2;AltName: Full=Protein Sck
Species	Homo sapiens
Common Name	Human
NCBI Taxonomy	9606
Gene	SHC2 \| SCK,SHC
Function	Signaling adapter that couples activated growth factors receptors to signaling pathway in neurons
Fragment	0
Sequence	MTQGPGGRAPPAPPAPPEPEAPTTFCALLPRMPQWKFAAPGGFLGRGPAAARAAGASGGA DPQPEPAGPGGVPALAAAVLGACEPRCAAPCPLPALSRCRGAGSRGSRGGRGAAGSGDAA AAAEWIRKGSFIHKPAHGWLHPDARVLGPGVSYVVRYMGCIEVLRSMRSLDFNTRTQVTR EAINRLHEAVPGVRGSWKKKAPNKALASVLGKSNLRFAGMSISIHISTDGLSLSVPATRQ VIANHHMPSISFASGGDTDMTDYVAYVAKDPINQRACHILECCEGLAQSIISTVGQAFEL RFKQYLHSPPKVALPPERLAGPEESAWGDEEDSLEHNYYNSIPGKEPPLGGLVDSRLALT QPCALTALDQGPSPSLRDACSLPWDVGSTGTAPPGDGYVQADARGPPDHEEHLYVNTQGL DAPEPEDSPKKDLFDMRPFEDALKLHECSVAAGVTAAPLPLEDQWPSPPTRRAPVAPTEE QLRQEPWYHGRMSRRAAERMLRADGDFLVRDSVTNPGQYVLTGMHAGQPKHLLLVDPEGV VRTKDVLFESISHLIDHHLQNGQPIVAAESELHLRGVVSREP

Interacting with G-proteins:

G-proteins

No	Name	Regulation	PubMed
1	Ggamma-8_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
2	Ggamma-4_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
3	Ggamma-5_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
4	Gbeta-4_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
5	Ggamma-11_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
6	Gbeta-5_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
7	Gbeta-1_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
8	Ggamma-2_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
9	Gbeta-like_Homo sapiens_1	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
10	Ggamma-t1_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
11	Ggamma-10_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
12	Ggamma-12_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
13	Ggamma-13_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
14	Ggamma-t2_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
15	Gbeta-3_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
16	Ggamma-7_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
17	Gbeta-like_Homo sapiens_2	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
18	Gbeta-2_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
19	Ggamma-3_Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118

GPCR, G-protein, Effector interaction

Visualizaton of GPCR, G-protein, Effector interaction at protein level