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Description Entry page for GPCR - 'TACHYKININ RECEPTORS_NK1_Homo sapiens'
ClassCLASS A
FamilyTACHYKININ RECEPTORS
Sub-FamilyNK1
Cross References:
References
UniProtP25103 | A8K150
EMBLS62045 | M74290 | M81797 | M76675 | X65177 | X65178 | X65179 | X65180 | X65181 | M84425 | M84426 | AY462098 | AK289765 | CH471053 | BC074911 | BC074912
InterProIPR000276 | IPR017452 | IPR001681 | IPR000046
PRODOM
GENEID6869
MIM162323
PRINTSPR00237 | PR01024 | PR00244
PFAMPF00001
Other GPCR resourcesGPCRDB | GPCR-OKB | GLIDA
Details:
Details
NameTACHYKININ RECEPTORS_NK1_Homo sapiens
DescriptionRecName: Full=Substance-P receptor; Short=SPR;AltName: Full=NK-1 receptor; Short=NK-1R;AltName: Full=Tachykinin receptor 1
SpeciesHomo sapiens
Common NameHuman
NCBI Taxonomy9606
GeneTACR1 | NK1R,TAC1
FunctionThis is a receptor for the tachykinin neuropeptides substance P
Fragment0
Sequence
MDNVLPVDSDLSPNISTNTSEPNQFVQPAWQIVLWAAAYTVIVVTSVVGNVVVMWIILAH
KRMRTVTNYFLVNLAFAEASMAAFNTVVNFTYAVHNEWYYGLFYCKFHNFFPIAAVFASI
YSMTAVAFDRYMAIIHPLQPRLSATATKVVICVIWVLALLLAFPQGYYSTTETMPSRVVC
MIEWPEHPNKIYEKVYHICVTVLIYFLPLLVIGYAYTVVGITLWASEIPGDSSDRYHEQV
SAKRKVVKMMIVVVCTFAICWLPFHIFFLLPYINPDLYLKKFIQQVYLAIMWLAMSSTMY
NPIIYCCLNDRFRLGFKHAFRCCPFISAGDYEGLEMKSTRYLQTQGSVYKVSRLETTIST
VVGAHEEEPEDGPKATPSSLDLTSNCSSRSDSKTMTESFSFSSNVLS
Interacting with G-proteins:
G-proteins
NoNameCouplingPubMed
1Galpha-q_Homo sapiensGq/111370820
2Galpha-13_Homo sapiensG12/131370820
3Galpha-s_Homo sapiens_1Gs1370820
4Galpha-12_Homo sapiensG12/131370820
5Galpha-11_Homo sapiensGq/111370820
6Galpha-14_Homo sapiensGq/111370820
7Galpha-s_Homo sapiens_2Gs1370820
8Galpha-15_Homo sapiensGq/111370820
GPCR, G-protein, Effector interaction Visualizaton of GPCR, G-protein, Effector interaction at protein level