Human-gpDB

	Human-gpDB
	A database of human GPCRs, G-proteins, Effectors and their interactions

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Description

Entry page for G-protein - 'Gbeta-2_Homo sapiens'

Class	Gbeta
Family	Gbeta
Sub-Family	Gbeta
Type	Gbeta-2

Cross References:

References

UniProt	P62879 \| P11016 \| P54312
EMBL	M16514 \| M36429 \| M16538 \| AF053356 \| AF501883 \| BC010073 \| BC012348 \| BC068003
InterPro	IPR020472 \| IPR001632 \| IPR016346 \| IPR015943 \| IPR001680 \| IPR019782 \| IPR019775 \| IPR017986 \| IPR019781
PRODOM	PD000018
GENEID	2783
MIM	139390
PRINTS	PR00319 \| PR00320
PFAM	PF00400

Details:

Details

Name	Gbeta-2_Homo sapiens
Description	RecName: Full=Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2;AltName: Full=Transducin beta chain 2;AltName: Full=G protein subunit beta-2
Species	Homo sapiens
Common Name	Human
NCBI Taxonomy	9606
Gene	GNB
Function	Guanine nucleotide-binding proteins (G proteins) ares involved as a modulator or transducer in various transmembranes signaling systems
Fragment	0
Sequence	MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYA MHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNI CSIYSLKTREGNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGF AGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYA FTTGSDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAM KGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Effectors:

Effectors

No	Name	Regulation	PubMed
1	SHC transforming protein 2-Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
2	Tubulin-Homo sapiens-3	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
3	Tubulin-Homo sapiens-10	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
4	Adenylate cyclase 7-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
5	GRK3-Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
6	Tubulin-Homo sapiens-19	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
7	Voltage dependent R type calcium channel-Homo sapiens	Inhibition	15251227 \| 11031246
8	Calmodulin-Homo sapiens	Inhibition of calmodulin kinase	15251227
9	Tubulin-Homo sapiens-11	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
10	ATP-sensitive inward rectifier potassium channel 8-Homo sapiens	Stimulation	15251227 \| 10990455
11	Phospholipase C beta 3-Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
12	Tubulin-Homo sapiens-22	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
13	Tubulin-Homo sapiens-13	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
14	Tubulin-Homo sapiens-8	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
15	Ras specific nucleotide exchange factor CDC25-Homo sapiens	Stimulation (indirect activation of ras)	15251227 \| 8717044
16	Rho-Homo sapiens-3	Recruitment to plasma membrane	15251227
17	Dynamin 1-Homo sapiens	Increased GTPase activity	15251227 \| 14671004
18	Tubulin-Homo sapiens-5	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
19	Tubulin-Homo sapiens-27	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
20	ATP-sensitive inward rectifier potassium channel 10-Homo sapiens	Stimulation	15251227 \| 10990455
21	ATP-sensitive inward rectifier potassium channel 11-Homo sapiens	Stimulation	15251227 \| 10990455
22	Tubulin-Homo sapiens-4	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
23	Tubulin-Homo sapiens-17	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
24	PI3K gamma-Homo sapiens	Activation	12502714
25	Tubulin-Homo sapiens-25	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
26	Tubulin-Homo sapiens-6	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
27	Tubulin-Homo sapiens-16	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
28	Kinase suppressor of Ras(KSR)-Homo sapiens	Sequestration of Gbeta/gamma	15251227
29	Rac-Homo sapiens-1	"Stimulation,Recruitment to plasma membrane"	11099498 \| 15251227
30	SHC transforming protein 3-Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
31	Voltage dependent N type calcium channel-Homo sapiens	Inhibition	15251227 \| 11031246
32	ATP-sensitive inward rectifier potassium channel 12-Homo sapiens	Stimulation	15251227 \| 10990455
33	ATP-sensitive inward rectifier potassium channel 1-Homo sapiens	Stimulation	15251227 \| 10990455
34	Rac-Homo sapiens-3	"Stimulation,Recruitment to plasma membrane"	11099498 \| 15251227
35	Tubulin-Homo sapiens-2	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
36	Rho-Homo sapiens-2	Recruitment to plasma membrane	15251227
37	Tubulin-Homo sapiens-12	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
38	Cdc42-Homo sapiens	"Stimulation,Recruitment to plasma membrane"	11099498 \| 15251227
39	Tubulin-Homo sapiens-15	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
40	Tubulin-Homo sapiens-24	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
41	SHC transforming protein 1-Homo sapiens	Stimulation(indirect activation of MAPK)	15251227 \| 14671004 \| 7568118
42	Tubulin-Homo sapiens-1	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
43	Adenylate cyclase 2-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
44	Brutons tyrosine kinase-Homo sapiens	Stimulation	15251227 \| 11698416
45	Adenylate cyclase 1-Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933 \| 10449730
46	Tubulin-Homo sapiens-26	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
47	Tubulin-Homo sapiens-20	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
48	GRK2-Homo sapiens	Recruitment to plasma membrane	15251227 \| 14654303
49	Tubulin-Homo sapiens-14	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
50	Tubulin-Homo sapiens-21	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
51	ATP-sensitive inward rectifier potassium channel 15-Homo sapiens	Stimulation	15251227 \| 10990455
52	Rho-Homo sapiens-1	Recruitment to plasma membrane	15251227
53	Tsk tyrosine kinase-Homo sapiens	Stimulation	15251227 \| 14671004
54	Protein kinase D-Homo sapiens	Stimulation	15251227
55	Raf1 protein kinase-Homo sapiens	Sequestration of Gâã	15251227
56	Tubulin-Homo sapiens-18	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
57	Phospholipase C beta 1-Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
58	PI3K alpha-Homo sapiens	Propable Inhibition	16182515
59	ATP-sensitive inward rectifier potassium channel 14-Homo sapiens	Stimulation	15251227 \| 10990455
60	Tubulin-Homo sapiens-9	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
61	Adenylate cyclase 6-Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933
62	Tubulin-Homo sapiens-23	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
63	Tubulin-Homo sapiens-7	Increased GTPase activity	15251227 \| 14671004 \| 12807915 \| 17705289 \| 16380086
64	Rac-Homo sapiens-2	"Stimulation,Recruitment to plasma membrane"	11099498 \| 15251227
65	PI3K beta-Homo sapiens	Activation	9305878 \| 12502714
66	Adenylate cyclase 4-Homo sapiens	Stimulation	15251227 \| 15922020 \| 14993377 \| 11376933
67	Voltage dependent P/Q type calcium channel-Homo sapiens	Inhibition	15251227 \| 11031246
68	Phospholipase C beta 2-Homo sapiens	Stimulation	15251227 \| 11015615 \| 8383116
69	Adenylate cyclase 5-Homo sapiens	Inhibition	15251227 \| 15922020 \| 14993377 \| 11376933

Interacton with GPCRs:

Coupling with GPCRs

Name

Coupling

PubMed